Results 61 to 70 of about 22,516 (258)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

An investigation of Eccentric Versus Concentric Resistance Training: The Role of Movement Velocity and Training Type

Türk Spor ve Egzersiz Dergisi, 2018
It is known that high intensity dynamic resistance training which involves eccentric and concentric contractions is one of the effective method for maximizing strength.
Settar Koçak, Gürcan Ünlü
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

The effects of eccentric arm crank training on upper body performance in elite athletes with a spinal cord injury

Current Issues in Sport Science
Introduction Eccentric strength training is a promising approach to improving upper body strength in athletes, as this type of training has several advantages over training that involves concentric or isometric muscle action (Hoppeler, 2016 ...
Fabian Ammann, Ann Knuchel, Anneke Hertig-Godeschalk, Claudio Perret   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Eccentric training with a powered rowing machine

Medicine in Novel Technology and Devices, 2019
The aim of this study was to investigate the effects of eccentric workloads generated by a powered rowing machine on the cardiorespiratory, cardiovascular and musculoskeletal systems. It was hypothesized that beneficial physiological effects would result by training with high eccentric workloads.
Humberto De las Casas, Kevin Kleis, Hanz Richter, Kenneth Sparks, Antonie van den Bogert   +4 more
openaire   +2 more sources

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

EFFECTIVENESS OF ECCENTRIC TRAINING, DYNAMIC RANGE OF MOTION EXERCISES AND STATIC STRETCHING ON FLEXIBILITY OF HAMSTRING MUSCLE AMONG FOOTBALL PLAYERS.

International Journal of Physiotherapy, 2015
Background: Hamstring stretch is an important part of treatment programs aimed at decreasing the likelihood of hamstring injury. Few studies have examine the effect of eccentric training, static stretching and dynamic range of motion(DROM) exercise in ...
Askar P.V, Veena Pais, Nagarajan Mohan, Shaikhji Saad, Nusaibath M Shaikhji   +4 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source