Results 41 to 50 of about 22,516 (258)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Utilisation of performance markers to establish the effectiveness of cold-water immersion as a recovery modality in elite football.

Biology of Sport, 2021
Optimal strategies for recovery following training and competition in elite athletes presents ongoing debate. The effects of cold-water immersion (CWI) compared to passive recovery (PR) though a triad of performance measures after fatiguing exercise ...
Jill Alexander, Chris Carling, David Rhodes   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Effects of Different Isokinetic Training Programs on Hamstring/Quadriceps Ratio and Proprioception in Patients with Patellofemoral Pain

Orthopaedic Journal of Sports Medicine, 2014
Objectives: To determine the effects of different isokinetic training programs; eccentric training, concentric training and combined (concentric-eccentric) training on quadriceps and hamstring muscle strength functional ratio (H/Qfunc ) and knee ...
Hande Güney, İnci Yüksel, Defne Kaya, Mahmut Nedim Doral   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Do Flywheel Exercises Provide Eccentric-Overload Training?

Sports Medicine - Open
Interests in eccentric resistance exercises have been increasing in both research and practice. However, implementing eccentric resistance exercise training is often challenging due to the mechanical limitations of traditional training equipment.
Darjan Spudić, Kazunori Nosaka
doaj   +1 more source

Combined Eccentric-Isokinetic and Isoinertial Training Leads to Large Ring-Specific Strength Gains in Elite Gymnasts

Sports, 2022
In male elite gymnastics, lately, eccentric training is often used to improve the maximum specific strength of static elements on rings. Therefore, in this study, we aimed to investigate the effects of a three-week, gymnastic-specific, eccentric ...
Christoph Schärer, Pascal Bucher, Fabian Lüthy, Klaus Hübner   +3 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Eccentric overload differences between loads and training variables on flywheel training

Biology of Sport, 2023
There is considerable debate about the existence of a real eccentric overload in flywheel exercises. This study aimed to analyse the differences in concentric: eccentric mechanical output ratios between different loads and variables in the flywheel squat exercise.
Alejandro Muñoz-López, Fábio Yuzo Nakamura, Marco Beato   +2 more
openaire   +4 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source