Results 41 to 50 of about 14,789 (259)

Increased insulin/insulin growth factor signaling advances the onset of metamorphosis in Drosophila. [PDF]

PLoS ONE, 2009
Mechanisms by which attainment of specific body sizes trigger developmental transitions to adulthood (e.g. puberty or metamorphosis) are incompletely understood.
Magdalena A Walkiewicz, Michael Stern
doaj   +1 more source

The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction

Nature Communications, 2021
Pupariation in Drosophila is triggered by the steroid-hormone ecdysone and requires coordination between associated behavioral and body-reshaping motor subprograms.
Fabiana Heredia, Yanel Volonté, Joana Pereirinha, Magdalena Fernandez-Acosta, Andreia P. Casimiro, Cláudia G. Belém, Filipe Viegas, Kohtaro Tanaka, Juliane Menezes, Maite Arana, Gisele A. Cardoso, André Macedo, Malwina Kotowicz, Facundo H. Prado Spalm, Marcos J. Dibo, Raquel D. Monfardini, Tatiana T. Torres, César S. Mendes, Andres Garelli, Alisson M. Gontijo   +19 more
doaj   +1 more source

Deep sequencing of the prothoracic gland transcriptome reveals new players in insect ecdysteroidogenesis. [PDF]

PLoS ONE, 2017
Ecdysteroids are steroid hormones that induce molting and determine developmental timing in arthropods. In insect larva, the prothoracic gland (PG) is a major organ for ecdysone synthesis and release.
Takayoshi Nakaoka, Masatoshi Iga, Tetsuya Yamada, Ikumi Koujima, Mika Takeshima, Xiangying Zhou, Yutaka Suzuki, Mari H Ogihara, Hiroshi Kataoka   +8 more
doaj   +1 more source

Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis

eLife, 2014
Despite their fundamental importance for body size regulation, the mechanisms that stop growth are poorly understood. In Drosophila melanogaster, growth ceases in response to a peak of the molting hormone ecdysone that coincides with a nutrition ...
Takashi Koyama, Marisa A Rodrigues, Alekos Athanasiadis, Alexander W Shingleton, Christen K Mirth   +4 more
doaj   +1 more source

Neurogrit Gold Attenuates 6-OHDA-Induced Dopaminergic Neurodegeneration in Parkinson's Model of Caenorhabditis elegans by Reducing α-Synuclein Accumulation and Pink/Pdr-1 Driven Mitochondrial Dysfunction. [PDF]

CNS Neurosci Ther
The study describes the therapeutic potential of Neurogrit Gold as a neuroprotective agent in the context of Parkinson's disease (PD). NG reduced α‐synuclein protein aggregation in NL5901 C. elegans. Furthermore, NG improved mitochondrial health in 6‐OHDA‐induced dopaminergic neurodegeneration in wild‐type worms and prevented DA neurodegeneration in ...
Balkrishna A, Pathak N, Singh R, Gohel V, Varshney Y, Dev R, Varshney A.   +6 more
europepmc   +2 more sources

Ecdysone Oxidase: Reaction and Specificity [PDF]

European Journal of Biochemistry, 1978
Ecdysone oxidase oxidizes 3‐hydroxysteroids of the ecdysteroid type irreversibly to 3‐dehydro derivatives. The hydrogen of the steroid is transferred by the enzyme to oxygen which is reduced to hydrogen peroxide. Ecdysone oxidase is relatively specific for ecdysone and ecdysterone. Apparent Michaelis constants for these two physiological substrates are
Jan Koolman, Peter Karlson
openaire   +3 more sources

Effects of methoxyfenozide on ecdysone receptor complex expression in larval Asian gypsy moth

Open Life Sciences, 2015
As a target of insect growth regulators, the ecdysone receptor complex binds ecdysone agonists to regulate gene transcription, development, and growth.
Wu Shao-ping, Sun Li-li, Zhong Hua, Yan Shan-chun, Wu Hong-qu, Wang Zhi-ying, Cao Chuan-wang   +6 more
doaj   +1 more source

EcR recruits dMi-2 and increases efficiency of dMi-2-mediated remodelling to constrain transcription of hormone-regulated genes

Nature Communications, 2017
InDrosophila, ecdysone-regulated genes are bound by a heterodimer of ecdysone receptor (EcR) and Ultraspiracle. Here, the authors provide evidence of a non-canonical complex containing EcR and the nucleosome remodeller dMi-2 that limits transcription of ...
Judith Kreher, Kristina Kovač, Karim Bouazoune, Igor Mačinković, Anna Luise Ernst, Erik Engelen, Roman Pahl, Florian Finkernagel, Magdalena Murawska, Ikram Ullah, Alexander Brehm   +10 more
doaj   +1 more source

The steroid hormone ecdysone regulates growth rate in response to oxygen availability

Scientific Reports, 2022
In almost all animals, physiologically low oxygen (hypoxia) during development slows growth and reduces adult body size. The developmental mechanisms that determine growth under hypoxic conditions are, however, poorly understood.
George P. Kapali, Viviane Callier, Samuel J. L. Gascoigne, Jon F. Harrison, Alexander W. Shingleton   +4 more
doaj   +1 more source

Developmental regulation of regenerative potential in Drosophila by ecdysone through a bistable loop of ZBTB transcription factors

PLoS Biology, 2019
In many organisms, the regenerative capacity of tissues progressively decreases as development progresses. However, the developmental mechanisms that restrict regenerative potential remain unclear.
Karine Narbonne-Reveau, C. Maurange
semanticscholar   +1 more source