In Vitro Binding Effects of the Ecdysone ReceptorâBinding Domain and PonA in Plutella xylostella [PDF]
Molecules, 2023 Both insect ecdysone receptors and ultraspiracle belong to the nuclear receptor family. They form a nanoscale self-assembling complex with ecdysteroids in cells, transit into the nucleus, bind with genes to initiate transcription, and perform specific ...
Yanjiao Feng +6 more
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The ecdysone receptor regulates several key physiological factors in Anopheles funestus [PDF]
Malaria Journal, 2022 Background Malaria is a devastating disease, transmitted by female Anopheles mosquitoes infected with Plasmodium parasites. Current insecticide-based strategies exist to control the spread of malaria by targeting vectors.
Surina Maharaj +6 more
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Nonsteroidal ecdysone receptor agonists use a water channel for binding to the ecdysone receptor complex EcR/USP. [PDF]
J Pestic Sci, 2021 The ecdysone receptor (EcR) possesses the remarkable capacity to adapt structurally to different types of ligands. EcR binds ecdysteroids, including 20-hydroxyecdysone (20E), as well as nonsteroidal synthetic agonists such as insecticidal ...
Browning C +6 more
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Molecular interplay between ecdysone receptor and retinoid X receptor in regulating the molting of the Chinese mitten crab, Eriocheir sinensis. [PDF]
Front Endocrinol (Lausanne), 2023 Purpose Molting is a pivotal biological process regulated by the ecdysteroid signaling pathway that requires molecular coordination of two transcription factors, Ecdysone receptor (EcR) and ultraspiracle (USP) in arthropods.
Chen X +5 more
europepmc +4 more sources
Identification of ecdysone receptor target genes in the worker honey bee brains during foraging behavior [PDF]
Scientific Reports, 2023 Ecdysone signaling plays central roles in morphogenesis and female ovarian development in holometabolous insects. In the European honey bee (Apis mellifera L.), however, ecdysone receptor (EcR) is expressed in the brains of adult workers, which have ...
Shiori Iino +4 more
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Ecdysone receptor isoforms play distinct roles in larval-pupal-adult transition in Leptinotarsa decemlineata. [PDF]
Insect Sci, 2020 A heterodimer of two nuclear receptors, ecdysone receptor (EcR) and ultraspiracle, mediates 20âhydroxyecdysone (20E) signaling to modulate many aspects in insect life, such as molting and metamorphosis, reproduction, diapause and innate immunity.
Xu QY +6 more
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Bombyx mori Ecdysone Receptor B1 May Inhibit BmNPV Infection by Triggering Apoptosis. [PDF]
Insects, 2023 Simple Summary Ecdysone is an essential factor affecting host immunity, in addition to regulating insect metamorphosis. There are two isoforms of ecdysone receptors (EcR) in silkworm, BmEcR-B1, and BmEcR-A.
Su Z +10 more
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Rbf/E2F1 control growth and endoreplication via steroid-independent Ecdysone Receptor signalling in Drosophila prostate-like secondary cells. [PDF]
PLoS Genet, 2023 Dysregulation of cell cycle components results in the development and progression of several cancer types. Unusually, loss of the tumour suppressor gene, Retinoblastoma (Rb), and consequent activation of transcription factor E2F1 have been linked to late-
Sekar A +9 more
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Hormone-dependent activation and repression of microRNAs by the ecdysone receptor in the dengue vector mosquito Aedes aegypti. [PDF]
Proc Natl Acad Sci U S A, 2021 Significance Mosquitoes transmit numerous devastating human diseases. MicroRNAs play important roles in mosquito reproduction, but how their expression is controlled remains poorly understood.
He YZ, Aksoy E, Ding Y, Raikhel AS.
europepmc +2 more sources
From Extrapolation to Precision Chemical Hazard Assessment: The Ecdysone Receptor Case Study. [PDF]
Toxics, 2021 Hazard assessment strategies are often supported by extrapolation of damage probabilities, regarding chemical action and species susceptibilities. Yet, growing evidence suggests that an adequate sampling of physiological responses across a representative
Ruivo R +7 more
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