Long-range repression by ecdysone receptor on complex enhancers of the insulin receptor gene [PDF]
Fly, 2023 The insulin signalling pathway is evolutionarily conserved throughout metazoans, playing key roles in development, growth, and metabolism. Misregulation of this pathway is associated with a multitude of disease states including diabetes, cancer, and ...
Katie D. Thompson +3 more
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The ecdysone receptor regulates several key physiological factors in Anopheles funestus [PDF]
Malaria Journal, 2022 Background Malaria is a devastating disease, transmitted by female Anopheles mosquitoes infected with Plasmodium parasites. Current insecticide-based strategies exist to control the spread of malaria by targeting vectors.
Surina Maharaj +6 more
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In Vitro Binding Effects of the Ecdysone Receptor−Binding Domain and PonA in Plutella xylostella [PDF]
Molecules, 2023 Both insect ecdysone receptors and ultraspiracle belong to the nuclear receptor family. They form a nanoscale self-assembling complex with ecdysteroids in cells, transit into the nucleus, bind with genes to initiate transcription, and perform specific ...
Yanjiao Feng +6 more
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Identification of ecdysone receptor target genes in the worker honey bee brains during foraging behavior [PDF]
Scientific Reports, 2023 Ecdysone signaling plays central roles in morphogenesis and female ovarian development in holometabolous insects. In the European honey bee (Apis mellifera L.), however, ecdysone receptor (EcR) is expressed in the brains of adult workers, which have ...
Shiori Iino +4 more
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Functional male accessory glands and fertility in Drosophila require novel ecdysone receptor. [PDF]
PLoS Genetics, 2017 In many insects, the accessory gland, a secretory tissue of the male reproductive system, is essential for male fertility. Male accessory gland is the major source of proteinaceous secretions, collectively called as seminal proteins (or accessory gland ...
Vandana Sharma +8 more
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Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis [PDF]
eLife, 2014 Despite their fundamental importance for body size regulation, the mechanisms that stop growth are poorly understood. In Drosophila melanogaster, growth ceases in response to a peak of the molting hormone ecdysone that coincides with a nutrition ...
Takashi Koyama +4 more
doaj +6 more sources
The nuclear receptors of Biomphalaria glabrata and Lottia gigantea: Implications for developing new model organisms [PDF]
, 2015 © 2015 Kaur et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Antebi +131 more
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Identification of Ecdysone Hormone Receptor Agonists as a Therapeutic Approach for Treating Filarial Infections. [PDF]
PLoS Neglected Tropical Diseases, 2016 BACKGROUND:A homologue of the ecdysone receptor has previously been identified in human filarial parasites. As the ecdysone receptor is not found in vertebrates, it and the regulatory pathways it controls represent attractive potential chemotherapeutic ...
Amruta S Mhashilkar +8 more
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Larval diapause termination in the bamboo borer, Omphisa fuscidentalis. [PDF]
PLoS ONE, 2017 In insects, juvenile hormone (JH) and 20-hydroxyecdysone (20E) regulate larval growth and molting. However, little is known about how this cooperative control is terminating larval diapause especially in the bamboo borer, Omphisa fuscidentalis.
Suphawan Suang +7 more
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Molecular evidence for a functional ecdysone signaling system in Brugia malayi. [PDF]
PLoS Neglected Tropical Diseases, 2010 BACKGROUND:Filarial nematodes, including Brugia malayi, the causative agent of lymphatic filariasis, undergo molting in both arthropod and mammalian hosts to complete their life cycles.
George Tzertzinis +7 more
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