Bicistronic Expression of Ecdysone-Inducible Receptors in Mammalian Cells [PDF]
BioTechniques, 2001 The recent emergence of inducible expression systems for mammalian cells has greatly facilitated the in vivo analysis of gene function. The ecdysone-inducible expression system is particularly attractive because of (i) extremely low basal expression and ...
Denise L. Wyborski +2 more
doaj +5 more sources
Long-range repression by ecdysone receptor on complex enhancers of the insulin receptor gene [PDF]
Fly, 2023 The insulin signalling pathway is evolutionarily conserved throughout metazoans, playing key roles in development, growth, and metabolism. Misregulation of this pathway is associated with a multitude of disease states including diabetes, cancer, and ...
Katie D. Thompson +3 more
doaj +5 more sources
Identification of ecdysone receptor target genes in the worker honey bee brains during foraging behavior [PDF]
Scientific Reports, 2023 Ecdysone signaling plays central roles in morphogenesis and female ovarian development in holometabolous insects. In the European honey bee (Apis mellifera L.), however, ecdysone receptor (EcR) is expressed in the brains of adult workers, which have ...
Shiori Iino +4 more
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Two adjacent cis-regulatory elements are required for ecdysone response of ecdysone receptor (EcR) B1 transcription. [PDF]
PLoS ONE, 2012 Three distinct classes of nuclear receptors, EcR, E75, and HR3, are key regulators in the ecdysone-inducible gene activation cascade in insects. The transcription of these genes is induced by ecdysone (20E) differently, although the detailed mechanisms ...
Hiroyuki Shirai +5 more
doaj +6 more sources
The ecdysone receptor regulates several key physiological factors in Anopheles funestus [PDF]
Malaria Journal, 2022 Background Malaria is a devastating disease, transmitted by female Anopheles mosquitoes infected with Plasmodium parasites. Current insecticide-based strategies exist to control the spread of malaria by targeting vectors.
Surina Maharaj +6 more
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In Vitro Binding Effects of the Ecdysone Receptor−Binding Domain and PonA in Plutella xylostella [PDF]
Molecules, 2023 Both insect ecdysone receptors and ultraspiracle belong to the nuclear receptor family. They form a nanoscale self-assembling complex with ecdysteroids in cells, transit into the nucleus, bind with genes to initiate transcription, and perform specific ...
Yanjiao Feng +6 more
doaj +2 more sources
Functional male accessory glands and fertility in Drosophila require novel ecdysone receptor. [PDF]
PLoS Genetics, 2017 In many insects, the accessory gland, a secretory tissue of the male reproductive system, is essential for male fertility. Male accessory gland is the major source of proteinaceous secretions, collectively called as seminal proteins (or accessory gland ...
Vandana Sharma +8 more
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Polished Rice Regulates Maturation but Not Survival of Secondary Cells in Drosophila Male Accessory Gland. [PDF]
Genes CellsNutrient signal‐dependent expression of Dve and Ecdysone receptor (EcR) determines the optimal number of SCs during the critical period. Subsequent maturation is regulated by the small peptide Polished rice (Pri) through the nutrient signal‐dependent EcR‐FtzF1‐Pri‐AbdB pathway. ABSTRACT In Drosophila males, the accessory gland is responsive to nutrient
Otsune S +4 more
europepmc +2 more sources
Azadirachtin disrupts ecdysone signaling and alters sand fly immunity [PDF]
Parasites & VectorsBackground Leishmaniasis is a group of neglected vector-borne diseases transmitted by phlebotomine sand flies. Leishmania parasites must overcome various defenses in the sand fly midgut, including the insects’s immune response.
Cecilia Stahl Vieira +4 more
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The Drosophila ecdysone receptor promotes or suppresses proliferation according to ligand level. [PDF]
Dev Cell, 2023 Perez-Mockus G +5 more
europepmc +2 more sources