Results 101 to 110 of about 7,003 (235)
CNS Neuroscience &Therapeutics, Volume 31, Issue 5, May 2025.The study describes the therapeutic potential of Neurogrit Gold as a neuroprotective agent in the context of Parkinson's disease (PD). NG reduced α‐synuclein protein aggregation in NL5901 C. elegans. Furthermore, NG improved mitochondrial health in 6‐OHDA‐induced dopaminergic neurodegeneration in wild‐type worms and prevented DA neurodegeneration in ...
Acharya Balkrishna +6 more
wiley +1 more source
Functional characterization of ecdysone receptor gene switches in mammalian cells [PDF]
The FEBS Journal, 2006 Regulated expression of transgene is essential in basic research as well as for many therapeutic applications. The main purpose of the present study is to understand the functioning of the ecdysone receptor (EcR)‐based gene switch in mammalian cells and to develop improved versions of EcR gene switches.
Prasanna Kumar +2 more
openaire +3 more sources
Role of Methoprene-tolerant (Met) in adult morphogenesis and in adult ecdysis of Blattella germanica. [PDF]
PLoS ONE, 2014 Juvenile Hormone (JH) represses metamorphosis of young instars in insects. One of the main players in hormonal signalling is Methoprene-tolerant (Met), which plays the role of JH receptor.
Jesus Lozano, Xavier Belles
doaj +1 more source
eLife, 2017 An important question in neuroscience is how stem cells generate neuronal diversity. During Drosophila embryonic development, neural stem cells (neuroblasts) sequentially express transcription factors that generate neuronal diversity; regulation of the ...
Mubarak Hussain Syed +2 more
doaj +1 more source
Epigenetic regulation affects gene amplification in Drosophila development
Frontiers in Bioscience-Landmark, 2020 In Drosophila melanogaster, in response to developmental transcription factors, and by repeated initiation of DNA replication of four chorion genes, ovarian follicle cells, form an onion skin-type structure at the replication origins. The DNA replication
Hidetsugu Kohzaki +3 more
doaj +1 more source
Multiple Routes for Glutamate Receptor Trafficking: Surface Diffusion and Membrane Traffic Cooperate to Bring Receptors to Synapses [PDF]
Science's STKE (electronic resource) : signal transduction
knowledge environment 327 (21/03/2006) 13, 2007 Trafficking of glutamate receptors into and out of synapses is critically involved in the plasticity of excitatory synaptic transmission. Endocytosis and exocytosis of receptors have initially been thought to account alone for this trafficking. However, membrane proteins also traffic through surface lateral diffusion in the plasma membrane. We describe
arxiv
Drosophila model systems reveal intestinal stem cells as key players in aging
Annals of the New York Academy of Sciences, Volume 1547, Issue 1, Page 88-99, May 2025.In this review, we discuss the regulation of proliferation and differentiation of intestinal stem cells based on previous research findings, summarize studies on the signaling pathways that regulate these stem cell functions, and describe how aging phenotypes observed in intestinal stem cells due to aging and oxidative stress affect intestinal ...
Joung‐Sun Park +2 more
wiley +1 more source
Ecdysone receptor homologs from mollusks, leeches and a polychaete worm
FEBS Letters, 2010 The genomes of the mollusk Lottia gigantea, the leech Helobdella robusta and the polychaete worm Capitella teleta each have a gene encoding an ecdysone receptor homolog. Publicly available genomic and EST sequences also contain evidence for ecdysone receptors in the seahare Aplysia californica, the bobtail squid Euprymna scolopes and the medicinal ...
Jan A. Veenstra, Michel Laguerre
openaire +3 more sources
Adhesion of membranes via receptor-ligand complexes: Domain formation, binding cooperativity, and active processes [PDF]
, 2009 Cell membranes interact via anchored receptor and ligand molecules. Central questions on cell adhesion concern the binding affinity of these membrane-anchored molecules, the mechanisms leading to the receptor-ligand domains observed during adhesion, and the role of cytoskeletal and other active processes.
arxiv +1 more source
CRISPR/Cas: An emerging molecular technology for biological control of fall armyworm
New Plant Protection, Volume 2, Issue 1, March 2025.The application of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated (Cas) for controlling agricultural pests, including fall armyworm, is still facing technological, ethical, and biosafety challenges. This review briefly discusses some major challenges and highlights ongoing multidisciplinary progress made to enable ...
Ehab El‐Awaad, Hans Merzendorfer
wiley +1 more source