The genome-wide transcriptional regulatory landscape of ecdysone in the silkworm
Epigenetics & Chromatin, 2018 Background The silkworm, Bombyx mori, a typical representative of metamorphic insects, is of great agricultural and economic importance. The steroid hormone ecdysone (20-hydroxyecdysone, 20E) is the central regulator of insect developmental transitions ...
Dong Cheng +7 more
doaj +1 more source
TGF-β receptor levels regulate the specificity of signaling pathway activation and biological effects of TGF-β [PDF]
, 2009 TGF-β is a pluripotent cytokine that mediates its effects through a receptor composed of TGF-β receptor type II (TGFBR2) and type I (TGFBR1). The TGF-β receptor can regulate Smad and nonSmad signaling pathways, which then ultimately dictate TGF-β's ...
Cress, Dean +3 more
core +3 more sources
Sex‐Specific Response to Predator Auditory Cues in Asian Corn Borer (Ostrinia furnacalis)
Ecology and Evolution, Volume 16, Issue 1, January 2026.Females downregulate more DEGs; males upregulate under predation risk. Males boost ecdysteroid; females reduce fecundity under bat ultrasound. Female O. furnacalis reacted more strongly to auditory cues of bats than males. ABSTRACT Predation risk has profound effects on prey from phenotype to gene expression.
Li Wang +8 more
wiley +1 more source
Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death [PDF]
, 2006 Histolysis refers to a widespread disintegration of tissues that is morphologically distinct from apoptosis and often associated with the stimulation of autophagy. Here, we establish that a component of the apoptosome, and pivotal regulator of apoptosis,
Abrams, John M. +11 more
core +1 more source
Spatiotemporal Crosstalk Between Oocyte and the Microenvironment Governs Preovulatory Follicle Aging
Aging Cell, Volume 25, Issue 1, January 2026.Preovulatory follicle aging is characterized by two distinct phases—early oocyte protective and late degenerative phases. The degenerative phase involves a positive feedback loop between oocyte mitochondrial dysfunction mediated by a mitochondrial‐localized microprotein PIGBOS, and granulosa cell functional decline through a circular RNA circdlg1 ...
Xin Yi Koh +7 more
wiley +1 more source
Ecdysone receptor homologs from mollusks, leeches and a polychaete worm
FEBS Letters, 2010 The genomes of the mollusk Lottia gigantea, the leech Helobdella robusta and the polychaete worm Capitella teleta each have a gene encoding an ecdysone receptor homolog. Publicly available genomic and EST sequences also contain evidence for ecdysone receptors in the seahare Aplysia californica, the bobtail squid Euprymna scolopes and the medicinal ...
Laguerre, Michel, Veenstra, Jan A.
openaire +2 more sources
Steroid Receptor Isoform Expression in Drosophila Nociceptor Neurons Is Required for Normal Dendritic Arbor and Sensitivity. [PDF]
PLoS ONE, 2015 Steroid hormones organize many aspects of development, including that of the nervous system. Steroids also play neuromodulatory and other activational roles, including regulation of sensitivity to painful stimuli in mammals.
Aidan L McParland +4 more
doaj +1 more source
Roles of mechanistic target of rapamycin and transforming growth factor-B signaling in the molting gland (Y-organ) of the blackback land crab, Gecarcinus lateralis [PDF]
, 2016 Molting in decapod crustaceans is controlled by molt-inhibiting hormone (MIH), an eyestalk neuropeptide that suppresses production of ecdysteroids by a pair of molting glands (Y-organs or YOs). Eyestalk ablation (ESA) activates the YOs, which hypertrophy
Abuhagr, Ali M. +5 more
core +2 more sources
Metabolism of Epoxidised Withanolides by a Generalist and a Specialist Insect Species
ChemistryOpen, Volume 14, Issue 12, December 2025.Larvae of Heliothis (Chloridea) virescence and subflexa have the ability to convert the epoxidized terpenoid 4β‐hydroxywithanolide E (4BHWE) to withanolide S. The conversion is found by feeding the larvae an artificial diet supplemented with 13C‐labeled 4BHWE.
Marie Pauline Sell +4 more
wiley +1 more source
Activation of the IκB Kinase Complex and Nuclear Factor-κB Contributes to Mutant Huntingtin Neurotoxicity [PDF]
, 2004 Transcriptional dysregulation by mutant huntingtin (Htt) protein has been implicated in the pathogenesis of Huntington's disease (HD). We find that cultured cells expressing mutant Htt and striatal cells from HD transgenic mice have elevated nuclear ...
Khoshnan, Ali +5 more
core +1 more source