Results 201 to 210 of about 7,003 (235)

Drosophila ecdysone receptor functions as a constitutive activator in yeast

The Journal of Steroid Biochemistry and Molecular Biology, 1997
Transcriptional activation of the Drosophila ecdysone receptor (EcR) was studied in yeast cells, which carry a reporter plasmid containing the ecdysone response element in the absence or presence of its heterodimeric partners, ultraspiracle protein (USP) or human retinoid X receptor (RXRalpha).
Paul Mak, Fernando Dela Cruz
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Molecular Docking of Azadirachtin in Nuclear Ecdysone Receptor

Current Physical Chemistry, 2019
Background: The azadirachtin is a triterpenoid associated with growth inhibition in several kinds of insects which cause epidemic diseases like Dengue, Chikungunya and Malaria. Azadirachtin acts by inhibiting the Ecdysone Receptor (EcR), which is responsible from larvae phase in insects.
Alcedino Venancio da Silva, Daniel Augusto Barra de Oliveira, Edenilson dos Santos Niculau   +2 more
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An Immunophilin is a Component of the Insect Ecdysone Receptor (EcR) Complex

Insect Biochemistry and Molecular Biology, 1997
The ecdysone receptor (EcR) complex has been identified in the prothoracic gland of Manduca sexta by specific immunoprecipitation and Western blot analyses, and includes EcR, ultraspiracle (USP) and FKBP46. The EcR complex binds ponasterone A in a dose-dependent manner with a Kd of 7.04 x 10(-9) M.
Lawrence I. Gilbert, Emad S. Alnemri, Qisheng Song, Gerald Litwack   +3 more
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Functional ecdysone receptor is the product of EcR and Ultraspiracle genes

Nature, 1993
Although the biological activity of the insect moulting hormone ecdysone, is manifested through a hormonally regulated transcriptional cascade associated with chromosomal puffing, a direct association of the receptor with the puff has yet to be established.
Tso-Pang Yao, Barry M. Forman, Jasmine Chen, Ze-Yu Jiang, Ronald M. Evans, Peter Cherbas, Michael McKeown, Lucy Cherbas   +7 more
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Ecdysone receptor expression and activity in adult Drosophila melanogaster

Journal of Insect Physiology, 2011
Disrupting components of the ecdysone/EcR/USP signaling pathway in insects leads to morphological defects and developmental arrest. In adult Drosophila melanogaster decreased EcR function affects fertility, lifespan, behavior, learning, and memory; however we lack a clear understanding of how EcR/USP expression and activity impacts these phenotypes. To
Siddharth Tulsiani, Christoph C. Schwedes, Ginger E. Carney   +2 more
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Comparative toxicity and ecdysone receptor affinity of non-steroidal ecdysone agonists and 20-hydroxyecdysone in Chironomus tentans

Insect Biochemistry and Molecular Biology, 2002
Ecdysone agonists belonging to the bisacylhydrazine class of compounds are a new generation of insecticidal compounds that cause premature lethal molts in susceptible intoxicated insects. While two of the bisacylhydrazines (coded as RH-5992 and RH-2485) are predominantly toxic to lepidopteran pests, RH-5849, which has not been commercialized, has a ...
Smagghe, Guy, Dhadialla, T., Lezzi, Markus   +2 more
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The involvement of ecdysone and ecdysone receptor in regulating the expression of antimicrobial peptides in Chinese mitten crab, Eriocheir sinensis

Developmental & Comparative Immunology, 2020
The ecdysone, 20-hydroxyecdysone (20E) and ecdysone receptor (EcR), are regarded as the key regulators of development, metamorphosis, and growth in arthropods. In the present study, the role of 20E and EsEcR in regulating the expression of antimicrobial peptides (AMPs) was investigated in Chinese mitten crab, Eriocheir sinensis.
Siqi Xu, Jiejie Sun, Shu Huang, Chuanyan Yang, Linsheng Song, Lingling Wang, Qilin Yi, Xingye Lian   +7 more
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Transcriptional activation of the Drosophila ecdysone receptor by insect and plant ecdysteroids

Insect Biochemistry and Molecular Biology, 2000
A number of insect ecdysteroids, plant ecdysteroids and juvenoids were assayed for their ability to activate Drosophila nuclear receptors in transfected tissue culture cells. Discrete modifications to 20-hydroxyecdysone, the apparent natural ligand for the ecdysone receptor (EcR), conferred dramatic changes on the transcriptional activity of this ...
Keith D. Baker, David J. Mangelsdorf, James T. Warren, Lawrence I. Gilbert, Carl S. Thummel   +4 more
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An analysis of ecdysone receptor domains required for heterodimerization with ultraspiracle

Archives of Insect Biochemistry and Physiology, 1999
We have prepared several truncated versions of the Choristoneura fumiferana ecdysone receptor (CfEcR) cDNA to identify domains required for heterodimerization with C. fumiferana ultraspiracle (CfUSP). The CfEcR protein containing all six domains bound to hsp27 EcRE in the presence of CfUSP protein.
Subba Reddy Palli, Subba Reddy Palli, Tarlochan S. Dhadialla, Srini C. Perera, Srini C. Perera, Arthur Retnakaran, Meenakshi Sundaram, Meenakshi Sundaram, Peter J. Krell   +8 more
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Cloning and characterization of an ecdysone receptor cDNA from Locusta migratoria

Molecular and Cellular Endocrinology, 1998
To facilitate studies on the hormonal control of development in the migratory locust, Locusta migratoria, we have undertaken the cloning of cDNAs for nuclear hormone receptors. Sequences obtained by polymerase chain reaction (PCR) showed homology with receptor family members including the ecdysteroid receptor (EcR).
Virginia K. Walker, Jianzhong Zhang, David S Saleh, G.R. Wyatt   +3 more
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