Results 211 to 220 of about 7,003 (235)

Ligand binding by recombinant domains from insect ecdysone receptors

Insect Biochemistry and Molecular Biology, 2007
The ligand binding domains (LBDs) from the EcR and USP proteins of four insect pests (Lucilia cuprina, Myzus persicae, Bemisia tabaci, Helicoverpa armigera) were purified as recombinant heterodimers. The K(d) values for [(3)H]-ponasterone A binding by LBD heterodimers that included the hinge regions (i.e., DE/F heterodimers) ranged 0.7-2.5 nM, with K(i)
Garry N. Hannan, Lloyd D. Graham, Ruth E. Eaton, M. Bliese, Ronald J. Hill, Wynona M. Johnson, Anna Pawlak-Skrzecz, Linda Howell   +7 more
openaire   +3 more sources

Identification of novel agonists and antagonists of the ecdysone receptor by virtual screening

Journal of Molecular Graphics and Modelling, 2018
Insect growth is regulated by the steroid hormone 20-hydroxyecdysone (20E), which works via the ecdysone receptor (EcR). To identify biologically active and novel ecdysone agonists/antagonists, ligand/structure-based virtual screening combined with pharmacophore modeling and molecular docking was performed to identify novel nonsteroidal lead compounds.
Xueping Hu, Bin Yin, Kaat Cappelle, Luc Swevers, Guy Smagghe, Xinling Yang, Li Zhang   +6 more
openaire   +2 more sources

Steroid Receptors and Other Transcription Factors in Ecdysone Response

1994
Publisher Summary This chapter discusses the steroid receptors and other transcription factors in ecdysone response. The early puff at cytogenetic locus 2B is the most interesting of the early puffs in some ways. Because of its location on the X chromosome, it was the first of the early genes to be characterized genetically.
openaire   +3 more sources

The influence of heterodimer partner ultraspiracle/retinoid X receptor on the function of ecdysone receptor

The FEBS Journal, 2005
A pair of nuclear receptors, ecdysone receptor (EcR) and ultraspiracle (USP), heterodimerize and transduce ecdysteroid signals. The EcR and its nonsteroidal ligands are being developed for regulation of transgene expression in humans, animals and plants.
Mariana Z. Kapitskaya, Subba Reddy Palli, David W. Potter   +2 more
openaire   +3 more sources

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Critical care management of chimeric antigen receptor T‐cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Alexander Shimabukuro-vornhagen, Victoria Metaxa, Elie Azoulay   +2 more
exaly  

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023
Rujul H Parikh
exaly  

The Structure and Function of Ecdysone Receptors

2009
Dino Moras, Dino Moras, Lloyd D. Graham, Christopher Browning, Christopher Browning, Michael C. Lawrence, Ronald J. Hill, Isabelle M. L. Billas, Isabelle M. L. Billas   +8 more
openaire   +2 more sources

Current treatment and recent progress in gastric cancer

Ca-A Cancer Journal for Clinicians, 2021
Smita S Joshi, Brian D Badgwell
exaly  

A review of cancer immunotherapy toxicity

Ca-A Cancer Journal for Clinicians, 2020
Lucy Boyce Kennedy
exaly