Results 41 to 50 of about 7,003 (235)
Direct imaging of lateral movements of AMPA receptors inside synapses [PDF]
EMBO J 22, 18 (15/09/2003) 4656-65, 2007 Trafficking of AMPA receptors in and out of synapses is crucial for synaptic plasticity. Previous studies have focused on the role of endo/exocytosis processes or that of lateral diffusion of extra-synaptic receptors. We have now directly imaged AMPAR movements inside and outside synapses of live neurons using single-molecule fluorescence microscopy ...
arxiv +1 more source
Interaction of the N-terminus of ecdysone receptor isoforms with the ligand-binding domain [PDF]
Molecular and Cellular Endocrinology, 2010 Ecdysone receptor (EcR) isoforms exert different biological functions, although they vary only in their N-terminal domain. Despite identical C-termini, which mediate hormone-induced activity, the influence of ligand is isoform specific, which indicates an N/C-interaction.
Ch. Tremmel +4 more
openalex +6 more sources
Diverse Hormone Response Networks in 41 Independent Drosophila Cell Lines
G3: Genes, Genomes, Genetics, 2016 Steroid hormones induce cascades of gene activation and repression with transformative effects on cell fate . Steroid transduction plays a major role in the development and physiology of nearly all metazoan species, and in the progression of the most ...
Marcus Stoiber +4 more
doaj +1 more source
Nature Communications, 2017 InDrosophila, ecdysone-regulated genes are bound by a heterodimer of ecdysone receptor (EcR) and Ultraspiracle. Here, the authors provide evidence of a non-canonical complex containing EcR and the nucleosome remodeller dMi-2 that limits transcription of ...
Judith Kreher +10 more
doaj +1 more source
Biology Open, 2021 Steroid hormones influence diverse biological processes throughout the animal life cycle, including metabolism, stress resistance, reproduction, and lifespan.
Byoungjoo Yoo +12 more
doaj +1 more source
Large number of receptors may reduce cellular response time variation [PDF]
Physical biology 10 (3), 035008, 2013, 2012 Cells often have tens of thousands of receptors, even though only a few activated receptors can trigger full cellular responses. Reasons for the overabundance of receptors remain unclear. We suggest that, in certain conditions, the large number of receptors results in a competition among receptors to be the first to activate the cell.
arxiv +1 more source
Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis
eLife, 2014 Despite their fundamental importance for body size regulation, the mechanisms that stop growth are poorly understood. In Drosophila melanogaster, growth ceases in response to a peak of the molting hormone ecdysone that coincides with a nutrition ...
Takashi Koyama +4 more
doaj +1 more source
Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities
Cellular Physiology and Biochemistry, 2018 Background/Aims: Ecdysteroids are steroidal insect molting hormones that also exist in herbs. Ecdysteroid-containing adaptogens have been popularly used to improve well-being and by bodybuilders for muscle growth.
Minglei Lu +9 more
doaj +1 more source
Ecdysone-Related Biomarkers of Toxicity in the Model Organism Chironomus riparius: Stage and Sex-Dependent Variations in Gene Expression Profiles. [PDF]
PLoS ONE, 2015 Despite being considered a model organism in toxicity studies, particularly in assessing the environmental impact of endocrine disrupting compounds (EDCs) and other chemicals, the molecular basis of development is largely unknown in Chironomus riparius ...
Rosario Planelló +5 more
doaj +1 more source
Frontiers in Genetics, 2021 There is growing evidence that peptides encoded by small open-reading frames (sORF or smORF) can fulfill various cellular functions and define a novel class regulatory molecules.
Azza Dib +11 more
doaj +1 more source