Ecdysone Receptor Agonism Leading to Lethal Molting Disruption in Arthropods: Review and Adverse Outcome Pathway Development. [PDF]
Environ Sci Technol, 2017 Song Y +4 more
europepmc +2 more sources
The ecdysone receptor puzzle [PDF]
Archives of Insect Biochemistry and Physiology, 1999 The present article reviews some recent findings on the functional ecdysone† receptor which is a heterodimer of two proteins: ecdysone receptor (EcR) and Ultraspiracle (USP). Emphasis is given to some unique aspects of this receptor, in particular to its dimerization, binding to DNA, and transactivation capabilities.
M. Lezzi +3 more
openaire +1 more source
26-[125I]iodoponasterone A is a potent ecdysone and a sensitive radioligand for ecdysone receptors. [PDF]
Proceedings of the National Academy of Sciences, 1988 The effects of ecdysone, the steroid molting hormone of arthropods, are of considerable interest both to insect physiologists and to those studying steroid-regulated gene expression. Yet progress in understanding ecdysone receptors has been inhibited by the lack of a suitable highly radioactive hormone analog with high affinity for the receptor.
Peter Cherbas +3 more
openalex +4 more sources
Drosophila Ecdysone Receptor Mutations Reveal Functional Differences among Receptor Isoforms [PDF]
Cell, 1997 The steroid hormone ecdysone directs Drosophila metamorphosis via three heterodimeric receptors that differ according to which of three ecdysone receptor isoforms encoded by the EcR gene (EcR-A, EcR-B1, or EcR-B2) is activated by the orphan nuclear receptor USP.
Bender, Michael +4 more
openaire +2 more sources
Nuclear receptor DHR4 controls the timing of steroid hormone pulses during Drosophila development. [PDF]
PLoS Biology, 2011 In insects, precisely timed periodic pulses of the molting hormone ecdysone control major developmental transitions such as molts and metamorphosis. The synthesis and release of ecdysone, a steroid hormone, is itself controlled by PTTH (prothoracicotopic
Qiuxiang Ou +2 more
doaj +1 more source
Cryptocephal, the Drosophila melanogaster ATF4, is a specific coactivator for ecdysone receptor isoform B2. [PDF]
PLoS Genetics, 2012 The ecdysone receptor is a heterodimer of two nuclear receptors, the Ecdysone receptor (EcR) and Ultraspiracle (USP). In Drosophila melanogaster, three EcR isoforms share common DNA and ligand-binding domains, but these proteins differ in their most N ...
Sebastien A Gauthier +4 more
doaj +1 more source
Ecdysone acts through cortex glia to regulate sleep in Drosophila
eLife, 2023 Steroid hormones are attractive candidates for transmitting long-range signals to affect behavior. These lipid-soluble molecules derived from dietary cholesterol easily penetrate the brain and act through nuclear hormone receptors (NHRs) that function as
Yongjun Li +4 more
doaj +1 more source
Correction: Functional male accessory glands and fertility in Drosophila require novel ecdysone receptor. [PDF]
PLoS Genet, 2017 Sharma V +8 more
europepmc +3 more sources
Drosophila microRNA-34 Impairs Axon Pruning of Mushroom Body γ Neurons by Downregulating the Expression of Ecdysone Receptor. [PDF]
Sci Rep, 2016 Lai YW +8 more
europepmc +3 more sources
Interactions of ultraspiracle with ecdysone receptor in the transduction of ecdysone‐ and juvenile hormone‐signaling [PDF]
The FEBS Journal, 2005 Analyses of integration of two‐hormone signaling through the vertebrate nuclear hormone receptors, for which the retinoid X receptor is one partner, have generated a number of mechanistic models, including those described as ‘subordination’ models wherein ligand‐activation of one partner is subordinate to the liganded state of the other partner ...
Fang, Fang +3 more
openaire +2 more sources