Results 71 to 80 of about 7,003 (235)

A Thermodynamic Model for Receptor Clustering [PDF]

, 1999
Intracellular signaling often arises from ligand-induced oligomerization of cell surface receptors. This oligomerization or clustering process is fundamentally a cooperative behavior between near-neighbor receptor molecules; the properties of this cooperative process clearly affects the signal transduction.
arxiv   +1 more source

High- and low-conductance NMDA receptors are present in layer 4 spiny stellate and layer 2/3 pyramidal neurons of mouse barrel cortex [PDF]

Physiological Reports, 30th Dec. 2016, Vol. 4 no. e13051, 2016
NMDA receptors are ion channels activated by the neurotransmitter glutamate in the mammalian brain and are important in synaptic function and plasticity, but are also found in extrasynaptic locations and influence neuronal excitability. There are different NMDA receptor subtypes which differ in their single-channel conductance.
arxiv   +1 more source

The quest for the best target genes for RNAi‐mediated pest control

Insect Molecular Biology, EarlyView.
A major challenge for RNAi mediated pest control is the identification of the most effective RNAi target genes from the pool of ~37% of all genes that are essential. Effective RNAi target genes are predominantly highly conserved genes serving basic cellular functions such as protein degradation.
Doga Cedden, Gregor Bucher
wiley   +1 more source

Mating induces switch from hormone-dependent to hormone-independent steroid receptor-mediated growth in Drosophila secondary cells.

PLoS Biology, 2019
Male reproductive glands like the mammalian prostate and the paired Drosophila melanogaster accessory glands secrete seminal fluid components that enhance fecundity.
Aaron Leiblich, Josephine E E U Hellberg, Aashika Sekar, Carina Gandy, Claudia C Mendes, Siamak Redhai, John Mason, Mark Wainwright, Pauline Marie, Deborah C I Goberdhan, Freddie C Hamdy, Clive Wilson   +11 more
doaj   +1 more source

Activation of Drosophila hemocyte motility by the ecdysone hormone

Biology Open, 2013
Summary Drosophila hemocytes compose the cellular arm of the fly's innate immune system. Plasmatocytes, putative homologues to mammalian macrophages, represent ∼95% of the migratory hemocyte population in circulation and are responsible for the ...
Christopher J. Sampson, Unum Amin, Juan-Pablo Couso   +2 more
doaj   +1 more source

Cargo binding promotes KDEL receptor clustering at the mammalian cell surface [PDF]

Sci. Rep. 6, 28940, 2016, 2017
Transmembrane receptor clustering is a ubiquitous phenomenon in pro- and eukaryotic cells to physically sense receptor/ligand interactions and subsequently translate an exogenous signal into a cellular response. Despite that receptor cluster formation has been described for a wide variety of receptors, ranging from chemotactic receptors in bacteria to ...
arxiv   +1 more source

Role of Atg3, Atg5 and Atg12 in the crosstalk between apoptosis and autophagy in the posterior silk gland of Bombyx mori

Insect Molecular Biology, Volume 34, Issue 3, Page 470-485, June 2025.
Autophagy‐related genes exert their effects not only by regulating autophagy but also by modulating apoptosis. This study provided evidence for anti‐apoptotic effects of Atg3 and Atg5 and pro‐apoptotic effects of Atg12 in the posterior silk gland.
Ebru Goncu, Esen Poyraz Tinartas, Busra Gunay, Tugce Ordu, Gamze Turgay Izzetoglu   +4 more
wiley   +1 more source

A time course analysis through diapause reveals dynamic temporal patterns of microRNAs associated with endocrine regulation in the butterfly Pieris napi

Molecular Ecology, EarlyView.
Abstract Organisms inhabiting highly seasonal environments must cope with a wide range of environmentally induced challenges. Many seasonal challenges require extensive physiological modification to survive. In winter, to survive extreme cold and limited resources, insects commonly enter diapause, which is an endogenously derived dormant state ...
Kevin T. Roberts, Rachel A. Steward, Philip Süess, Philipp Lehmann, Christopher W. Wheat   +4 more
wiley   +1 more source

DNA affects ligand binding of the ecdysone receptor of Drosophila melanogaster [PDF]

Molecular and Cellular Endocrinology, 2009
The heterodimers of all three ecdysone receptor (EcR) isoforms with Ultraspiracle (Usp), the invertebrate orthologue of RXR, bind Ponasterone A with the same affinity in the absence of DNA. Ligand binding is stimulated by ecdysone response elements (EcREs) to different degrees depending on the receptor isoform, the heterodimerization partner, and the ...
Anca Azoitei, Margarethe Spindler-Barth
openaire   +3 more sources

Method for Screening Ecdysone-Inducible Stable Cell Lines

BioTechniques, 2001
Ecdysone-inducible systems are useful tools to study the function of various genes in different types of mammalian cells. However, it is technically difficult to establish stable cell lines.
Kenichi Wakita, Frank McCormick, Osamu Tetsu   +2 more
doaj   +1 more source