Results 81 to 90 of about 7,003 (235)
Metabolites, 2023 Cholesterol is necessary for all cells to function. The intracellular cholesterol transporters Npc1 and Npc2 control sterol trafficking and their malfunction leads to Neimann–Pick Type C disease, a rare disorder affecting the nervous system and the ...
Constantina Neophytou +2 more
doaj +1 more source
Polar Chemoreceptor Clustering by Coupled Trimers of Dimers [PDF]
Biophys J 96(2): 453-463 (2009), 2009 Receptors of bacterial chemotaxis form clusters at the cell poles, where clusters act as "antennas" to amplify small changes in ligand concentration. Interestingly, chemoreceptors cluster at multiple length scales. At the smallest scale, receptors form dimers, which assemble into stable timers of dimers.
arxiv +1 more source
Comparative analysis of the molecular starvation response of Southern Ocean copepods
Molecular Ecology, EarlyView.Abstract Large lipid‐storing copepods dominate mesozooplankton biomass in the polar oceans and form a critical link between primary production and higher trophic levels. The ecological success of these species depends on their ability to survive periods of food deprivation in a highly seasonal environment, but the molecular changes that mediate ...
Cory A. Berger +3 more
wiley +1 more source
Functional analysis of ecdysone receptor
, 2009 Ecdysteroids are important regulators of insect development. They perform their actions through intracellular receptors belonging to the superfamily of nuclear receptors (NRs). In the present study, the relative performance of the three Drosophila ecdysone receptor (EcR)-isoforms in terms of their affinity to the ligand Ponasterone A in mammalian cell ...
openaire +2 more sources
Detection in Molecular Communications with Ligand Receptors under Molecular Interference [PDF]
arXiv, 2020 Molecular Communications (MC) is a bio-inspired communication technique that uses molecules to transfer information among bio-nano devices. In this paper, we focus on the detection problem for biological MC receivers employing ligand receptors to infer the transmitted messages encoded into the concentration of molecules, i.e., ligands.
arxiv
Formation and Stability of Synaptic Receptor Domains [PDF]
Phys. Rev. Lett. 106, 238104 (2011), 2010 Neurotransmitter receptor molecules, concentrated in postsynaptic domains along with scaffold and a number of other molecules, are key regulators of signal transmission across synapses. Employing experiment and theory, we develop a quantitative description of synaptic receptor domains in terms of a reaction-diffusion model.
arxiv +1 more source
Medical and Veterinary Entomology, EarlyView.Morin hydrate promoted mortality and reduced the rate of pupation and egg laying in Aedes aegypti larvae that survive treatment. Morin hydrate reduces the levels of triacylglycerol, the main lipid reserve in A. aegypti larvae. The expression of proteins involved in lipogenesis and lipolysis was downregulated and upregulated, respectively, in larvae ...
Luan Valim dos Santos +9 more
wiley +1 more source
Steered molecular dynamics for studying ligand unbinding of ecdysone receptor
Journal of Biomolecular Structure and Dynamics, 2017 Ecdysone receptor (EcR) is an important target for pesticide design. Ligand binding regulates EcR transcriptional activity similar to other nuclear receptors; however, the pathways by which ligands enter and leave the EcR remain poorly understood.
Xueping Hu +5 more
openaire +2 more sources
The genome-wide transcriptional regulatory landscape of ecdysone in the silkworm
Epigenetics & Chromatin, 2018 Background The silkworm, Bombyx mori, a typical representative of metamorphic insects, is of great agricultural and economic importance. The steroid hormone ecdysone (20-hydroxyecdysone, 20E) is the central regulator of insect developmental transitions ...
Dong Cheng +7 more
doaj +1 more source
iMeta, Volume 4, Issue 3, June 2025.Schematic representation of the design. Tryptophan metabolism is enriched in serum metabolites and gut microbiota of centenarians, potentially contributing to healthy longevity. A key tryptophan metabolite 5‐methoxyindoleacetic acid (5‐MIAA) is linked to the Christensenellaceae R‐7 group and exhibits effects of delaying cell senescence, promoting ...
Xiaorou Qiu +16 more
wiley +1 more source