Results 1 to 10 of about 432 (139)

Metabolic profiling of an Echinostoma caproni infection in the mouse for biomarker discovery. [PDF]

PLoS Neglected Tropical Diseases, 2008
BACKGROUND: Metabolic profiling holds promise with regard to deepening our understanding of infection biology and disease states. The objectives of our study were to assess the global metabolic responses to an Echinostoma caproni infection in the mouse ...
Jasmina Saric, Jia V Li, Yulan Wang, Jennifer Keiser, Jake G Bundy, Elaine Holmes, Jürg Utzinger   +6 more
doaj   +7 more sources

Panorganismal Metabolic Response Modeling of an Experimental Echinostoma caproni Infection in the Mouse [PDF]

Journal of Proteome Research, 2009
Metabolic profiling of host tissues and biofluids during parasitic infections can reveal new biomarker information and aid the elucidation of mechanisms of disease. The multicompartmental metabolic effects of an experimental Echinostoma caproni infection have been characterized in 12 outbred female mice infected orally with 30 E.
JASMINA Saric, Jia V Li, Yulan Wang
exaly   +7 more sources

Antibody trapping: A novel mechanism of parasite immune evasion by the trematode Echinostoma caproni. [PDF]

PLoS Neglected Tropical Diseases, 2017
Helminth infections are among the most prevalent neglected tropical diseases, causing an enormous impact in global health and the socioeconomic growth of developing countries. In this context, the study of helminth biology, with emphasis on host-parasite
Alba Cortés, Javier Sotillo, Carla Muñoz-Antolí, Javier Molina-Durán, J Guillermo Esteban, Rafael Toledo   +5 more
doaj   +2 more sources

Differential alterations in the small intestine epithelial cell turnover during acute and chronic infection with Echinostoma caproni (Trematoda) [PDF]

Parasites & Vectors, 2015
Background The intestinal epithelium plays a multifactorial role in mucosal defense. In this sense, augmented epithelial cell turnover appears as a potential effector mechanism for the rejection of intestinal-dwelling helminths.
Alba Cortés, Carla Muñoz-Antoli, Carla Martín-Grau, J. Guillermo Esteban, Richard K. Grencis, Rafael Toledo   +5 more
doaj   +2 more sources

Altered Protein Expression in the Ileum of Mice Associated with the Development of Chronic Infections with Echinostoma caproni (Trematoda). [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:Echinostoma caproni (Trematoda: Echinostomatidae) is an intestinal trematode that has been extensively used as experimental model to investigate the factors determining the expulsion of intestinal helminths or, in contrast, the development of ...
Alba Cortés, Javier Sotillo, Carla Muñoz-Antoli, Bernard Fried, J Guillermo Esteban, Rafael Toledo   +5 more
doaj   +2 more sources

Susceptibility of mice to primary Echinostoma caproni infections is associated with metabolic and structural changes [PDF]

Frontiers in Immunology
BackgroundHelminth infections are among the most prevalent neglected tropical diseases, causing an enormous impact in health and the socioeconomic status of developing countries.
Emma Fiallos, Paola Cociancic, José Guillermo Esteban, Carla Muñoz-Antoli, Rafael Toledo   +4 more
doaj   +2 more sources

Ileal proteomic changes associated with IL-25-mediated resistance against intestinal trematode infections [PDF]

Parasites & Vectors, 2020
Background Echinostoma caproni (Trematoda: Echinostomatidae) is an intestinal trematode, which has been extensively used to investigate the factors that determine the rejection of intestinal helminths. In this sense, several studies have shown that IL-25
María Álvarez-Izquierdo, J. Guillermo Esteban, Carla Muñoz-Antoli, Rafael Toledo   +3 more
doaj   +2 more sources

Activity of OZ78 analogues against Fasciola hepatica and Echinostoma caproni. [PDF]

Acta Trop, 2011
The rapid spread of triclabendazole resistance in veterinary medicine is an important motivation for the discovery and development of novel fasciocidal drugs. The aim of this study was to characterize the fasciocidal properties of 1,2,4,5-tetraoxane (MT04 and MT14) and 1,2,4-trioxane (ST16 and ST28) analogues of the fasciocidal drug candidate OZ78, a 1,
Kirchhofer C, Vargas M, Braissant O, Dong Y, Wang X, Vennerstrom JL, Keiser J.   +6 more
europepmc   +6 more sources

Interleukin-25-mediated resistance against intestinal trematodes does not depend on the generation of Th2 responses [PDF]

Parasites & Vectors, 2020
Background The cytokine interleukin-25 (IL-25) is recognized as the most relevant initiator of protective T helper 2 (Th2) responses in intestinal helminth infections.
María Álvarez-Izquierdo, Miguel Pérez-Crespo, J. Guillermo Esteban, Carla Muñoz-Antoli, Rafael Toledo   +4 more
doaj   +2 more sources

Anthelmintic Activity and Pathophysiological Effect of <i>Allium sativum</i> Extract-Based Copper Nanoparticles Against the Carcinogenic Liver Fluke, <i>Opisthorchis viverrini</i>. [PDF]

J Parasitol Res
Opisthorchis viverrini has a significant role in cholangiocarcinoma (CCA), a leading cause of death in northeastern Thailand. Although praziquantel (PZQ) remains the standard treatment for O. viverrini infections, its use is associated with adverse side effects, and prolonged administration may increase the risk of CCA. In response, the Thai government
Arunsan P, Pechdee P, Phinsiri S, Boonsuya A, Thanchonnang C, La N, Keeratibharat N, Rattanapitoon NK, Rattanapitoon SK.   +8 more
europepmc   +2 more sources