Results 151 to 160 of about 230,272 (282)

Decellularization and Solubilization of Human Chorion Membrane: a Novel ECM Supplement/Substrate for Mesenchymal Stem Cells Culture

, 2018
Samuel Herlander da Cruz José
openalex   +2 more sources

A Novel Microfluidic System for 3D Epidermis and Full‐Thickness Skin Growth for Nanoparticle Safety Assessment

Advanced Healthcare Materials, EarlyView.
This work presents a novel, dynamically perfused, configurable microfluidic system for epidermis‐only (E and full‐thickness skin (FT SoC) growth, emulating human skin structure and barrier function. Upon TiO2 nanoparticle exposure, the system reveals compromised barrier integrity, reduced metabolic activity, increased permeability, and chemokine‐driven
Samantha Costa, Ana B. Carneiro, Filipa Lebre, João Meneses, Alar Ainla, Cacilda Moura, Ernesto Alfaro‐Moreno, Ana R. Ribeiro   +7 more
wiley   +1 more source

The role of metformin in extracellular matrix-based three-dimensional cell culture Models: A mini-review on therapeutic potentials. [PDF]

Biochem Biophys Rep
Zamani M, Soltani N.
europepmc   +1 more source

ECM receptor pathway analysis; collagen, laminin, fibronectin, vitronectin, osteopontin, von Willebrand factor, chondroadherin, and reelin transcripts.

, 2015
Yurika Tachibana, Sakurai Toshihiro, Hanako Bai, Shiota Kunio, Yasuo NAMBO, Kentaro Nagaoka, Kazuhiko Imakawa   +6 more
openalex   +2 more sources

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

Single-cell profiling reveals lineage-specific fibroblast stromal subtypes drive ECM remodeling and immune modulation in the hepatocellular carcinoma tumor microenvironment. [PDF]

Med Oncol
Jiang Z, Wang H, Li H, Chen Z, Sun B.
europepmc   +1 more source

Precise Control of Drug Release in Machine Learning‐Designed Antibody‐Eluting Implants for Postoperative Scarring Inhibition in Glaucoma

Advanced Healthcare Materials, EarlyView.
We developed a micro‐sized, biocompatible implant for postoperative sustained delivery of anti‐fibrotic antibodies in glaucoma surgery. Machine learning‐guided optimization of polymer composition, implant geometry, and porosity enabled precise control of drug release.
Mengqi Qin, Wenbing Jiang, Kai Xin Thong, Zeynep Ulker, Brihitejas Patel, Cynthia Yu‐Wai‐Man   +5 more
wiley   +1 more source

Normalizing the Tumor Microenvironment: A New Frontier in Ovarian Cancer Therapy. [PDF]

Int J Mol Sci
Jones AP, Zhao Y, Rueda BR, Yeku OO, Xu L.   +4 more
europepmc   +1 more source

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

The Extracellular Matrix and the Immune System in Acute Lung Injury: Partners in Damage and Repair. [PDF]

Biomedicines
Xie F, Sun Y, Wang J, Luo W, Zhang X, Cheng Y, Chao J.   +6 more
europepmc   +1 more source