Results 121 to 130 of about 183,658 (172)

Isolation of In Vitro Osteoblastic-Derived Matrix Vesicles by Ultracentrifugation and Cell-Free Mineralization Assay

Bio-Protocol
Matrix vesicles (MVs) represent a heterogeneous group of spherical membrane-bound extracellular vesicles in the range of 100–200 nm in diameter secreted by mineralizing osteoblasts.
Irshad Sheikh, Pawel Kiela, Fayez Ghishan   +2 more
doaj   +1 more source

The effects of bisphosphonates on ectopic soft tissue mineralization caused by mutations in the ABCC6 gene

, 2015
Pseudoxanthoma elasticum (PXE) and generalized arterial calcification of infancy (GACI) are heritable ectopic mineralization disorders. Most cases of PXE and many cases of GACI harbor mutations in the ABCC6 gene. There is no effective treatment for these
John P Sundberg (8391), Qiaoli Li (277667), Jouni Uitto (307381), Sharon F Terry (723116), Michael A Levine (274941)   +4 more
core   +1 more source

Expert Recommendations for Use of Combined Oral Contraceptives in Preadolescent and Young Adolescent Patients With Acne Vulgaris

Pediatric Dermatology, EarlyView.
ABSTRACT Acne vulgaris commonly presents in early adolescence with the onset of adrenarche. Treatments for acne in this age group typically mirror those in older adolescents. However, while combined oral contraceptives are an effective hormonal treatment for acne vulgaris in young women, the safety of using a systemic hormonal therapy in younger ...
Andrea L. Zaenglein, Natalie Allen, Sasigarn Bowden, Hannah R. Chang, Kristina Derrick, Alison Edelman, Dawn Eichenfield, Lawrence Eichenfield, Sarah Gold, Emmy Graber, Julie Harper, Sarah Horvath, Patricia Huguelet, Karin J. Kartawira, Leah Lalor, Irene Lara‐Corrales, Megha M. Tollefson, Tierney E. Wallace, Jonette Keri   +18 more
wiley   +1 more source

H19 Facilitates Hdpscs Dentinogenesis Via Mir-103A3p/Pik3r1/Klf4 Pathway

International Dental Journal
Aim or purpose: Functional reconstruction of the dentin-pulp complex is critical for repairing damaged teeth, with odontogenic differentiation of human dental pulp stem cells (hDPSCs) serving as a key process of reparative dentin formation.
Jingkun Zhang, Qianzhou Jiang
doaj   +1 more source

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement

Periodontology 2000, EarlyView.
Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen   +4 more
wiley   +1 more source

A new perspective on intervertebral disc calcification—from bench to bedside

Bone Research
Disc degeneration primarily contributes to chronic low back and neck pain. Consequently, there is an urgent need to understand the spectrum of disc degeneration phenotypes such as fibrosis, ectopic calcification, herniation, or mixed phenotypes.
Emanuel J. Novais, Rajkishen Narayanan, Jose A. Canseco, Koen van de Wetering, Christopher K. Kepler, Alan S. Hilibrand, Alexander R. Vaccaro, Makarand V. Risbud   +7 more
doaj   +1 more source

Long‐term stability of horizontal bone augmentation at implant sites

Periodontology 2000, EarlyView.
Abstract Horizontal bone augmentation is a fundamental surgical procedure in regenerative implant dentistry. In recent decades, this procedure has evolved, enabling clinicians to achieve predictable and stable horizontal bone augmentation that supports dental implant restorations.
Jia‐Hui Fu, Hui Jia Sophia Choo, Ding‐Sen Ong, Henry Kwek   +3 more
wiley   +1 more source

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

Updating the role of matrix metalloproteinases in mineralized tissue and related diseases

Journal of Applied Oral Science
Bone development and healing processes involve a complex cascade of biological events requiring well-orchestrated synergism with bone cells, growth factors, and other trophic signaling molecules and cellular structures. Beyond health processes, MMPs play
Cintia Kazuko Tokuhara, Mariana Rodrigues Santesso, Gabriela Silva Neubern de Oliveira, Talita Mendes da Silva Ventura, Julio Toshimi Doyama, Willian Fernando Zambuzzi, Rodrigo Cardoso de Oliveira   +6 more
doaj   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source