Results 131 to 140 of about 178,374 (209)

Efficacy and Safety of Elagolix Versus Dienogest for Treatment of Moderate‐to‐Severe Endometriosis Pain: A Phase III, Multicentric, Double‐Blind, Active‐Controlled, Non‐Inferiority Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 11, Page 2025-2034, October 2026.
ABSTRACT Objective To compare the efficacy, safety and tolerability of elagolix with dienogest in women with moderate‐to‐severe endometriosis‐associated pain. Design A multicentre, double‐blind, double‐dummy, randomised, parallel‐group, active‐controlled, non‐inferiority phase III study. Setting Nineteen clinical centres across India.
Sneha Bhoir, Jaldhara Patel, Tushar Palve, Mrinal Kanti Dash, Sweety Saigal, Gourisankar Kamilya, Shalini Srivastava, Kartikbhai Savalia, Tanusree Gupta, Deepa Choudhary, Manohar Rangaswamy, Vidya V Bhatt, Neena Gupta, Malathi Ponnuru, Parul Shah, Apurva Shetty, Shruti Saha, Reshma Quadros, Sucheta Pandit, Dipak Patil, Piyush Patel, Pravin Ghadge, Lalit Lakhwani, Suyog Mehta, Sadhana Joglekar   +24 more
wiley   +1 more source

A new perspective on intervertebral disc calcification—from bench to bedside

Bone Research
Disc degeneration primarily contributes to chronic low back and neck pain. Consequently, there is an urgent need to understand the spectrum of disc degeneration phenotypes such as fibrosis, ectopic calcification, herniation, or mixed phenotypes.
Emanuel J. Novais, Rajkishen Narayanan, Jose A. Canseco, Koen van de Wetering, Christopher K. Kepler, Alan S. Hilibrand, Alexander R. Vaccaro, Makarand V. Risbud   +7 more
doaj   +1 more source

H19 Facilitates Hdpscs Dentinogenesis Via Mir-103A3p/Pik3r1/Klf4 Pathway

International Dental Journal
Aim or purpose: Functional reconstruction of the dentin-pulp complex is critical for repairing damaged teeth, with odontogenic differentiation of human dental pulp stem cells (hDPSCs) serving as a key process of reparative dentin formation.
Jingkun Zhang, Qianzhou Jiang
doaj   +1 more source

Horizontal Ridge Augmentation Using an rhBMP‐2 Loaded Volume‐Stable Collagen Matrix Compared to Guided Bone Regeneration: A Preclinical In Vivo Study

Journal of Clinical Periodontology, Volume 53, Issue 10, Page 1610-1620, October 2026.
ABSTRACT Aim To investigate whether incorporation of recombinant human bone morphogenetic protein‐2 (rhBMP‐2) into a volume‐stable collagen matrix (VCMX) enhances horizontal ridge augmentation compared with VCMX alone or guided bone regeneration (GBR). Methods Chronic horizontal ridge defects were created in five canines.
Jin‐Young Park, Gi‐Seo Song, Seung‐Hyun Park, Lorenzo Tavelli, David T. Wu, Daniel S. Thoma, Ronald E. Jung, Ui‐Won Jung, Jae‐Kook Cha   +8 more
wiley   +1 more source

Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity

Obesity Reviews, Volume 27, Issue 10, October 2026.
ABSTRACT Excess adiposity is not a recently developed problem but has existed since at least the upper Paleolithic, allowing evolutionary selection pressures to adapt the physiology of the pregnant woman and the feto‐placental unit for maternal and fetal protection.
Gernot Desoye, Ursula Hiden, Evelyn Jantscher‐Krenn, Herbert Fluhr, Jonathan C. Wells, Sonja Entringer, Mireille N. M. van Poppel   +6 more
wiley   +1 more source

Updating the role of matrix metalloproteinases in mineralized tissue and related diseases

Journal of Applied Oral Science
Bone development and healing processes involve a complex cascade of biological events requiring well-orchestrated synergism with bone cells, growth factors, and other trophic signaling molecules and cellular structures. Beyond health processes, MMPs play
Cintia Kazuko Tokuhara, Mariana Rodrigues Santesso, Gabriela Silva Neubern de Oliveira, Talita Mendes da Silva Ventura, Julio Toshimi Doyama, Willian Fernando Zambuzzi, Rodrigo Cardoso de Oliveira   +6 more
doaj   +1 more source

CD31+ Cell Enrichment Enhances Therapeutic Effects of Stromal Vascular Fraction in Experimental Primary Osteoarthritis: A Preclinical Study in the Dunkin Hartley Guinea Pig Model

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Both SVF and CD31+ SVF improve spontaneous osteoarthritis, but CD31+ enrichment refines the therapeutic profile rather than broadly enhancing all effects. More distinct benefits are observed in extracellular matrix remodeling, osteochondral integrity, and subchondral/trabecular bone preservation, supporting CD31+‐enriched SVF as a biologically enhanced
Sijia Zhou, Tobias Winkler, Bin Chen, Marta Grzeski, Yilong Yang, Florian N. Fleckenstein, Dominik Geisel, Alexander Hildebrandt, Daniela Aschenbrenner, Marie Agatha Mohn, Benjamin Claass, January Weiner 3rd, Sven Geissler, Georg N. Duda, Søren P. Sheikh, Oliver Klein, Tazio Maleitzke   +16 more
wiley   +1 more source

Lifestyle Impacts the Oral Microbiome of Classical and Post‐Classical Societies in Italy

American Journal of Biological Anthropology, Volume 191, Issue 1, September 2026.
ABSTRACT Objectives The fall of the Roman Empire (476 CE) profoundly affected the lives of its peoples due to the political, administrative, and territorial changes that occurred. The majority of written records of the time focus on the social élite, leaving larger parts of the population understudied.
Martina Farese, Markella Moraitou, Chenyu Jin, Adrian Forsythe, Ileana Micarelli, Tom van der Valk, Giorgio Manzi, Laura Parducci, Mary Anne Tafuri, Katerina Guschanski   +9 more
wiley   +1 more source

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dentate gyrus subgranular cell zone (SGZ) of 5×FAD mice was measured using ...
Weiqi Sun, Biyu Yang, Hanyuan Zheng, Qi Wang, Yajiao Shi, Gandig Wang, Wang Yin, Hui Wang, Xuetao Qi, Yun Yao, Jiaxin Wang, Shuang Cui, Kun Cui, Jian Mao, Yiyuan Xia, Jianwen Deng, Siyuan Zhao, Zhihao Wang, Fengyu Liu, Ming Yi, Jiuyang Ding, Weidong Le, Xinyan Li, Junliang Yuan, You Wan, Jie Zheng   +25 more
wiley   +1 more source

Management of Mandibular Third Molars With an Interradicular Inferior Alveolar Nerve Using Ultrasonic Surgery: A Case Series of Three Patients

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT The interradicular course of the inferior alveolar nerve represents a significant challenge for oral surgeon. In this context, ultrasonic surgery may provide a precise and safe alternative for sectioning of impacted third molar roots, particularly in procedures involving mandibular molars with an interradicular course of the inferior alveolar ...
Antonio Scarano, Gianluca Nicolai, Ermal Pashaj, Sergio Alexandre Gehrke   +3 more
wiley   +1 more source