Results 11 to 20 of about 18,084 (203)

Rethinking Statin Dosage in Coronary Disease. [PDF]

Pharmacol Res Perspect
It is widely acknowledged that a sufficient statin dose is important in the management of symptomatic coronary disease, along with weight reduction and appropriate antithrombotic, blood pressure, and diabetes pharmacotherapy. Mid‐range statin doses have been shown to achieve the maximum improvements in total mortality and have the advantage of greater ...
Dimmitt SB, Stampfer HG, Kennedy MC, Martin JH.   +3 more
europepmc   +2 more sources

Antiseizure Effects of Cannabidiol in Combination With Cannabigerol in the Maximal Electroshock Seizure Model. [PDF]

Basic Clin Pharmacol Toxicol
Cannabidiol and cannabigerol suppress maximal electroshock seizures. Cannabidiol and cannabigerol show similar dose–response properties. Both cannabinoids show no toxicity at effective doses. ABSTRACT Current antiseizure therapy for epilepsy is only effective in about 70% of the patient population.
Zhou HZ, Scott BW, Oleksak YI, Burnham WM.   +3 more
europepmc   +2 more sources

The safety profile of the anesthetic effect of alfaxalone and its interaction with xylazine and ketamine in chick’s model (Gallus gallus domesticus)

Macedonian Veterinary Review, 2021
The objective of our research was to estimate the therapeutic index and assess the interaction of alfaxalone (IP) with ketamine or xylazine (IM) in chicks by using isobolographic analysis.
Amjed Najem Alatrushi, Ahmed Salah Naser
doaj   +1 more source

Effect of Allicin and Artesunate Combination Treatment on Experimental Mice Infected with Plasmodium berghei

Veterinary Medicine International, 2022
Malaria is still a significant health problem in endemic countries and increases Plasmodium resistance to the available antimalarial drugs. Hence, this study aimed to investigate the antimalarial activity of allicin and its combination with artesunate ...
Sakaewan Ounjaijean, Voravuth Somsak
doaj   +1 more source

Synergistic anti-allodynic effect between intraperitoneal thalidomide and morphine on rat spinal nerve ligation-induced neuropathic pain [PDF]

Korean Journal of Anesthesiology, 2013
BackgroundThalidomide has been recognized as having an anti-allodynic effect against neuropathic pain induced by spinal nerve ligation. Its clinical beneficial effects are mainly derived from its immune-modulating property, which is known to influence ...
Hyung Gon Lee, Woong Mo Kim, Myung Ha Yoon, A Reum Park, Jeong-Il Choi   +4 more
doaj   +1 more source

Combining Aggregate Data and Individual Patient Data in Model-Based Meta-Analysis: An Illustrative Case Study of Tofacitinib in Rheumatoid Arthritis Patients. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Model‐based meta‐analysis (MBMA) utilizes aggregate data (AD) and allows integration of information from multiple studies, which may provide more statistical power to detect clinically relevant treatment effects than an individual randomized controlled trial alone. Access to individual patient data (IPD) is often limited due to confidentiality;
Pham TN, Largajolli A, Sardu ML, Maringwa J, Zierhut ML, Cheung SYA.   +5 more
europepmc   +2 more sources

Increased diaphragm echodensity correlates with postoperative pulmonary complications in patients after major abdominal surgery: a prospective observational study

BMC Pulmonary Medicine, 2022
Background Associated with increased morbidity and mortality, postoperative pulmonary complications (PPCs) often occur after major abdominal surgery.
Xin Fu, Zhen Wang, Luping Wang, Guangxuan Lv, Yisong Cheng, Bo Wang, Zhongwei Zhang, Xiaodong Jin, Yan Kang, Yongfang Zhou, Qin Wu   +10 more
doaj   +1 more source

Synthesis of Benzopyrans and Quinolines with Nitrogenated Chain and Their Cytotoxicity Against Human Cancer Cell Lines [PDF]

ChemMedChem
Natural products and/or their structural analogs represent the greatest number of approved small‐molecules as antitumor agents. We report the synthesis of 2‐propanamide and 2‐propanamine dihydrobenzopyrans and 2‐ and 2,3‐disubstituted quinolines to evaluate their cytotoxicity against human A549 (lung), A2058 (melanoma), HepG2 (liver), MCF‐7 (breast ...
Álvaro B, Mackenzie T, Ramos M, García A, Villarroel‐Vicente C, Vila L, Tormo J, Cortes D, Cabedo N.   +8 more
europepmc   +2 more sources

Long-term high-risk drinking does not change effective doses of propofol for successful insertion of gastroscope in Chinese male patients

BMC Anesthesiology, 2022
Background Available literature indicates that long-term drinkers demand a higher dose of propofol for induction of anesthesia than non-drinkers. However, there is no study having assessed the influence of long-term high-risk drinking (LTHRD) on the ...
Pei-Pei Hao, Tian Tian, Bin Hu, Wei-Chao Liu, Ying-Gui Chen, Tian-Yu Jiang, Fu-Shan Xue   +6 more
doaj   +1 more source

Oxidative stress suppression contributes to antiseizure action of axitinib and rapamycin in pentylenetetrazol-induced kindling [PDF]

The Ukrainian Biochemical Journal, 2021
Rapamycin and axitinib block different kinases in signaling pathways such as PI3K-Akt-mTOR and BDNF-TrkB, respectively. Both have antiseizure and antioxidative actions, which justify studying the combined effects of these drugs upon seizures and ...
O. B. Poshyvak, O. R. Pinyazhko, L. S. Godlevsky   +2 more
doaj   +1 more source