Isobolographic Analysis of the Interaction Between Remimazolam and Etomidate in General Anesthesia Induction: A Prospective, Sequential Allocation Study Based on the Dixon Up-and-Down Method [PDF]
Drug Design, Development and TherapyWei Yue,1,* Jiayan Huang,2,* Qi Wang,2 Furong Zheng,2 Pengfei Yin,3 Yaohua Jin,2 Yue Wang,4 Linzhong Zhang1 1College of Anesthesiology, Shanxi Medical University and Department of Anesthesiology, Second Hospital of Shanxi Medical ...
Yue W +7 more
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Antimalarial Potency of Tinospora crispa Stem Extract and Artesunate Against Plasmodium berghei: A Study on Combination Therapy [PDF]
Journal of Tropical MedicineMalaria continues to be a significant global health burden, with over 249 million cases and 619,000 deaths reported in 2022, primarily affecting tropical and subtropical regions.
Sakaewan Ounjaijean, Voravuth Somsak
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Locomotor and discriminative stimulus effects of N-cyclohexyl butylone and N-cyclohexyl methylone [PDF]
Frontiers in PharmacologyBackgroundN-Cyclohexyl butylone and N-cyclohexyl methylone are cathinones found on the street that produce morbidity and mortality, but are not yet legally controlled, and there has been little or no pharmacological testing of these compounds.
Michael B. Gatch +5 more
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ED50 and ED95 of intrathecal levobupivacaine with opioids for Caesarean delivery [PDF]
British Journal of Anaesthesia, 2011 Abstract Background This prospective randomized double-blind dose–response study aimed to determine the ED 50 and ED 95 of intrathecal levobupivacaine combined with morphine and sufentanil for elective Caesarean delivery. Methods Parturients undergoing elective Caesarean delivery were included and allocated to five levobupivacaine dose groups (6,
Lionel Bouvet +2 more
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Resolving coral temperature vulnerability through heat and cold bleaching thresholds [PDF]
Communications BiologyCoral bleaching is most commonly associated with heat stress, while cold-water bleaching remains an underrecognized threat. Building upon the widely used ED50 metric for standardized heat tolerance, we introduce a new metric, cold ED50, to quantify cold ...
Yusuf C. El-Khaled +9 more
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Macedonian Veterinary Review, 2021 The objective of our research was to estimate the therapeutic index and assess the interaction of alfaxalone (IP) with ketamine or xylazine (IM) in chicks by using isobolographic analysis.
Amjed Najem Alatrushi, Ahmed Salah Naser
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Drug and Alcohol Dependence Reports, 2023 Aims: Benzofurans are used recreationally, due their ability to cause psychostimulant and/or entactogenic effects, but unfortunately produce substantial adverse effects, including death. Three benzofurans 5-(2-aminopropyl)-2,3-dihydrobenzofuran (5-APDB),
Rebecca D. Hill +4 more
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Veterinary Medicine International, 2022 Malaria is still a significant health problem in endemic countries and increases Plasmodium resistance to the available antimalarial drugs. Hence, this study aimed to investigate the antimalarial activity of allicin and its combination with artesunate ...
Sakaewan Ounjaijean, Voravuth Somsak
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Synergistic anti-allodynic effect between intraperitoneal thalidomide and morphine on rat spinal nerve ligation-induced neuropathic pain [PDF]
Korean Journal of Anesthesiology, 2013 BackgroundThalidomide has been recognized as having an anti-allodynic effect against neuropathic pain induced by spinal nerve ligation. Its clinical beneficial effects are mainly derived from its immune-modulating property, which is known to influence ...
Hyung Gon Lee +4 more
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ED50 of Propofol Combined with Nalbuphine on the Sedative Effect in Painless Hysteroscopy [PDF]
Pain and Therapy, 2021 Nalbuphine has gradually become a commonly used clinical analgesic drug for painless hysteroscopy. The aim of our study was to identify the median effective dose (ED50) of propofol combined with nalbuphine for painless hysteroscopy.Sixty-one patients aged 18-60 years were recruited to undergo elective painless hysteroscopy. Patients were administered 0.
Chen Chen +4 more
openaire +3 more sources