Results 51 to 60 of about 18,084 (203)

Blood‐Based Lead Biomarkers and Sarcopenia Indicators in Older Adults

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Chronic exposure to low levels of lead (Pb) remains a widespread public health issue, especially among older adults. While its neurotoxic and cardiovascular effects are well recognized, its potential role in accelerating age‐related musculoskeletal decline is less understood.
Aida Koni, Alvaro Santos‐Cuerva, Mercedes Sotos‐Prieto, Rosario Ortolá, Pablo Olmedo, Javier García‐Pérez, Rebeca Ramis, Adrián Carballo‐Casla, Fernando Gil, Javier González‐Palacios, Roberto Pastor‐Barriuso, Ana Navas‐Acién, Elena Plans‐Beriso, Pablo Fernández‐Navarro, Fernando Rodríguez‐Artalejo, Esther García‐Esquinas   +15 more
wiley   +1 more source

In vitro sensitivity testing of Cladobotryum mycophilum to carbendazim and prochloraz manganese

South African Journal of Science, 2015
Limited information of fungicide efficacy on cultivated mushrooms and resistance development potential is available. Minor crop industries in general have a smaller arsenal of protectants to rely on and the likelihood of resistance build-up is of greater
Alinesi Chakwiya, Elna J. van der Linde, Lise Korsten   +2 more
doaj   +1 more source

The effective doses of remimazolam besylate in the procedural sedation of endoscopic retrograde cholangiopancreatography

Ibrain, 2023
This study aimed to determine the values of the half‐effective dose (ED50) and 95% effective dose (ED95) of remimazolam besylate used in the procedural sedation of endoscopic retrograde cholangiopancreatography (ERCP).
Dan‐Dan Tan, Jin Gu, Juan Li, Wan‐Qiu Yu, De‐Xing Liu, Li‐Jin Zhao, Guo‐Hua Zhu, Xin‐Xin Yang, Jin Tian, Qi Tian, Zhao‐Qiong Zhu   +10 more
doaj   +1 more source

Examining the Reliability of Model‐Based Meta‐Analysis (MBMA) Outcomes: A Simulation Study

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Model‐based meta‐analysis (MBMA) can be utilized to synthesize literature data and predict drug efficacy, particularly suitable for constructing external comparator arms for non‐randomized controlled trials (NRCTs). This study evaluated the reliability of MBMA by comparing covariate models generated through MBMA to individual patient data.
Jiesen Yu, Ting Li, Jieren Luo, Qingshan Zheng, Lujin Li   +4 more
wiley   +1 more source

Preliminary evaluation of the efficacy and safety of brimonidine for general anesthesia

BMC Anesthesiology, 2021
Background To determine the hypnotic and analgesic effects of brimonidine, and evaluate its efficacy and safety for general anesthesia. Potentiation of pentobarbital sleeping time following brimonidine administration was observed in mice, as was the ...
Chen Bin, Wang Xiaohui, Shi Mengrou, Li Xin, Zhang Ting, Gao Ping   +5 more
doaj   +1 more source

The effect of parturient height on the median effective dose of intrathecally administered ropivacaine

Annals of Saudi Medicine, 2016
BACKGROUND: Pain during cesarean delivery is one of the more common reasons for a successful medico-legal claim. However, creating an extensive block area can result in hypotension, so determining the precise dose of local anesthetic is critical ...
Xiangdi Yu, Fangxiang Zhang
doaj   +1 more source

A selective breeding design based on parental rapid heat stress thresholds did not produce more heat‐tolerant coral larvae

Ecological Solutions and Evidence, Volume 7, Issue 1, January/March 2026.
Coral broodstock were phenotyped using a rapid heat stress assay and ranked according to their performance (photochemical efficiency). Selectively breeding the broodstock based on their performance did not produce larvae with enhanced heat tolerance. Created in BioRender. Lamb, A. (2025) https://BioRender.com/zcgk0g6.
Annika M. Lamb, Carys A. Morgans, Guy A. McCutchan, Véronique J. L. Mocellin, Hugo Denis, Melissa S. Naugle, Annelise J. Lemonius, Richard C. Edmunds, Michael K. Wooster, Line K. Bay, Emily J. Howells, Madeleine J. H. van Oppen   +11 more
wiley   +1 more source

Combined sedation in pediatric magnetic resonance imaging: determination of median effective dose of intranasal dexmedetomidine combined with oral midazolam

BMC Anesthesiology
Background The exact median effective dose (ED50) of intranasal dexmedetomidine combined with oral midazolam sedation for magnetic resonance imaging (MRI) examination in children remains unknow and the aim of this study was to determine the ED50 of their
Hao Xie, Jialian Zhao, Haiya Tu, Wenyang Wang, Yaoqin Hu   +4 more
doaj   +1 more source

Could the Biological Potency of Porcelia macrocarpa R.E. Fries (Annonaceae) be Linked to Its Diverse Metabolite Profile?

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Porcelia macrocarpa is a Brazilian plant species belonging to the Annonaceae family. To date, more than 190 compounds have been identified and/or isolated from this species, with terpenoids comprising the majority (62%). Alkaloids represent the second most abundant class (11%), followed by steroids (4%), acetogenins (4%), fatty acids (4 ...
Fernanda Thevenard, Ivanildo A. Brito, Emerson A. Oliveira, Mariana H. Chaves, João Henrique G. Lago   +4 more
wiley   +1 more source

Development of a Novel Aedes aegypti Repellent: An Integrated Approach Combining In Silico and Bioassays

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
OBP1 plays an essential role in the behavior response of Aedes aegypti. The computational approaches employed herein suggest a compound with repellency activity in the ZINC database, which was confirmed by bioassays. ABSTRACT Aedes aegypti is the most important vector of arboviruses, which are responsible for 3.9 billion cases worldwide.
Moysés Fagundes de Araujo Neto, Jânio Rodrigo de Jesus Santos, Ana Luiza Pontes Silva de Oliveira, Antonio Wanderson Vieira Gois, Ingrid Bernardes Santana Martins, Vitor Barbanti Pereira Leite, Adriano Figueiredo Monte Alegre, Jairo Torres Magalhães Junior, Franco Henrique Andrade Leite   +8 more
wiley   +1 more source