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Edaravone dexborneol compared to edaravone in the treatment of acute cerebral infarction: A meta-analysis [PDF]

Frontiers in Pharmacology
ObjectiveThe objective of this study was to systematically assess the clinical efficacy and safety of edaravone dexborneol compared to those of edaravone in treating acute cerebral infarction.MethodsWe searched the PubMed, Cochrane Library, Embase, CBM ...
Yanshuo Shi, Yanshuo Shi, Yuanyuan Yue, Yuanyuan Yue, Mi Wang, Huizhen Wu, Huizhen Wu   +6 more
doaj   +4 more sources

Effects of the Edaravone, a Drug Approved for the Treatment of Amyotrophic Lateral Sclerosis, on Mitochondrial Function and Neuroprotection

Antioxidants, 2022
Edaravone, the first known free radical scavenger, has demonstrated cellular protective properties in animals and humans. Owing to its antioxidant activity, edaravone modulates oxidative damage in various diseases, especially neurodegenerative diseases ...
Sun Joo Cha, Kiyoung Kim
exaly   +3 more sources

Edaravone Dexborneol Versus Edaravone Alone for the Treatment of Acute Ischemic Stroke [PDF]

Stroke, 2021
Background and Purpose: Edaravone dexborneol, comprised of 2 active ingredients, edaravone and (+)-borneol, has been developed as a novel neuroprotective agent with synergistic effects of antioxidant and anti-inflammatory in animal models.
Anxin Wang, Xia Meng, Anding Xu
exaly   +3 more sources

Safety assessment of Edaravone: A real-world adverse event analysis based on the FAERS Database. [PDF]

PLoS ONE
ObjectiveEdaravone is a neuroprotective agent, but the characteristics of its adverse events (AEs) remain insufficiently explored. This study aims to examine AEs associated with edaravone use by analyzing real-world data from the FDA Adverse Event ...
Ziyue Wang, Bowen Lu, Hao Yang, Weijie Zhao, Xinru Kong, Chuanhao Mi, Jianlin Wu   +6 more
doaj   +2 more sources

Edaravone Dexborneol in acute ischemic stroke patients treated with combined intravenous thrombolysis and mechanical thrombectomy for large vessel occlusion [PDF]

Frontiers in Neurology
BackgroundMechanical thrombectomy (MT), when combined with intravenous thrombolysis (IVT), has emerged as an effective therapeutic strategy for acute ischemic stroke (AIS).
Bo Peng, Ruilong Wang, Wei Jiang, Mo Zou, Hao Li, Hongxu Zhang   +5 more
doaj   +2 more sources

Edaravone alleviates Alzheimer’s disease-type pathologies and cognitive deficits [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2015
Yu-Hui Liu, Fan Zeng, Ankit Parikh
exaly   +2 more sources

Edaravone dextrocamphorol combined with intravenous thrombolysis enhances recovery in acute ischemic stroke. [PDF]

Am J Transl Res
Wei B, Ji G, Fang L, Shi W.
europepmc   +2 more sources

Analysis of Long-Term Function and Survival of Edaravone Oral Suspension-Treated Patients With Amyotrophic Lateral Sclerosis Using PRO-ACT Data as Historical Placebo Controls. [PDF]

Muscle Nerve
Takahashi F, Genge A, Hirai M, Selness D, Todorovic V, Wamil A, Sasson N, Apple S, Ushirogawa Y, Pooled Resource Open‐Access ALS Clinical Trials Consortium.   +9 more
europepmc   +3 more sources

Edaravone efficacy in amyotrophic lateral sclerosis with reduced forced vital capacity: Post-hoc analysis of Study 19 (MCI186-19) [clinical trial NCT01492686]

PLoS ONE, 2022
Background Edaravone slowed the rate of functional decline in subjects with amyotrophic lateral sclerosis (ALS) in phase 3 study MCI186-19 (Study 19).
Benjamin Rix Brooks, Terry Heiman-Patterson, Martina Wiedau-Pazos, Shawn Liu, Jeffrey Zhang, Stephen Apple   +5 more
doaj   +2 more sources

Renoprotective Effects of Edaravone in a Model of Acute kidney Injury Induced by Rhabdomyolysis in Rats, the Involvement of Nitric oxide [PDF]

Trends in Pharmaceutical Sciences, 2022
Edaravone is a free radical scavenger which is used as a drug for the treatment of cerebral infarction and amyotrophic lateral sclerosis. Edaravone is distributed widely in the body and its effects are not limited to the neural tissue.
Leila Moezi, Mohammad Reza Panjehshahin, Simin Torabinezhad, Eskandar Kamali-Sarvestani, Shirin Farjadian, Fatema Pirsalami, Azin Ebrahimpour, Somayeh Oftadehgan, Azar Purkhosrow, Maryam Mojahedtaghi, Elahe Sattarinezhad   +10 more
doaj   +1 more source