Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons [PDF]
Background Parkinson's disease (PD) is a neurological disorder characterized by the degeneration of nigrostriatal dopaminergic systems. Free radicals induced by oxidative stress are involved in the mechanisms of cell death in PD. This study clarifies the
Wang Feifei+15 more
doaj +7 more sources
Protective Effects of Edaravone against Methamphetamine-Induced cardiotoxicity [PDF]
Methamphetamine (METH) is widely abused in worldwide. METH use could damage the dopaminergic system and induce cardiotoxicity via oxidative stress and mitochondrial dysfunction.
Motahareh Koohsari+2 more
doaj +5 more sources
Edaravone Attenuated Angiotensin II-Induced Atherosclerosis and Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Mice [PDF]
Background: The aim of the study was to define whether edaravone, a free-radical scavenger, influenced angiotensin II (AngII)-induced atherosclerosis and abdominal aortic aneurysms (AAAs) formation.
Haruhito A. Uchida+8 more
doaj +3 more sources
Effect of edaravone on pregnant mice and their developing fetuses subjected to placental ischemia [PDF]
Growing evidence indicates that reduced uterine perfusion pressure (RUPP) triggers the cascade of events leading to preeclampsia. Edaravone is a powerful free radical scavenger used for the treatment of ischemia/reperfusion diseases due to its anti ...
Marwa Atallah, Toru Yamashita, Koji Abe
doaj +2 more sources
Edaravone dexborneol compared to edaravone in the treatment of acute cerebral infarction: A meta-analysis [PDF]
ObjectiveThe objective of this study was to systematically assess the clinical efficacy and safety of edaravone dexborneol compared to those of edaravone in treating acute cerebral infarction.MethodsWe searched the PubMed, Cochrane Library, Embase, CBM ...
Yanshuo Shi+6 more
doaj +2 more sources
Edaravone, a Radical Scavenger, Inhibits Mitochondrial Permeability Transition Pore in Rat Brain
Edaravone, a radical scavenger, prevents ischemia/reperfusion injury in the brain, but the detailed mechanism is not known. This study examines the effect of edaravone on mitochondrial permeability transition pore (PTP) in rat brain.
Yuko Takayasu+6 more
doaj +3 more sources
Association between edaravone use and activities of daily living in older patients with atherothrombotic stroke: an observational study using Japanese real-world data [PDF]
Background Edaravone is marketed in nine countries, although only Japan has approved edaravone for improvement of neurological symptom, disability of activities of daily living (ADL), and functional disability associated with acute stroke.
Yukari Ogawa+3 more
doaj +2 more sources
Edaravone leads to proteome changes indicative of neuronal cell protection in response to oxidative stress [PDF]
Neuronal cell death, in neurodegenerative disorders, is mediated through a spectrum of biological processes. Excessive amounts of free radicals, such as reactive oxygen species (ROS), has detrimental effects on neurons leading to cell damage via ...
Ahmadinejad, Fereshteh.+8 more
core +3 more sources
The protective effect of Edaravone against acute renocardiac syndrome in a kidney ischemia-reperfusion model [PDF]
Introduction: Acute kidney injury (AKI) is a common clinical occurrence causing high mortality and morbidity. In acute renocardiac syndrome, AKI leads to acute cardiac injury or/and dysfunction.
Yasin Bagheri+5 more
doaj +2 more sources
Neuroprotective effect and possible mechanism of edaravone in rat models of spinal cord injury: a systematic review and network meta-analysis [PDF]
ObjectiveThe present review was developed to critically evaluate the neuroprotective effects of edaravone for experimental rat models of spinal cord injury (SCI) and generalize the possible mechanisms.MethodsSystematic searches were carried out on ...
Long-yun Zhou+13 more
doaj +2 more sources