Results 41 to 50 of about 5,356 (175)

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, Volume 3, Issue 3, Page 220-249, September 2026.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source

Edaravone protects against hyperosmolarity-induced oxidative stress and apoptosis in primary human corneal epithelial cells. [PDF]

PLoS ONE, 2017
An increase in the osmolarity of tears induced by excessive evaporation of the aqueous tear phase is a major pathological mechanism behind dry eye. Exposure of epithelial cells on the surface of the human eye to hyperosmolarity leads to oxidative stress,
Yanwei Li, Haifeng Liu, Wei Zeng, Jing Wei   +3 more
doaj   +1 more source

At‐Home Versus in‐Clinic Vital Capacity Measurement: Insights From the HEALEY ALS Platform Trial

Muscle &Nerve, Volume 74, Issue 3, Page 702-708, September 2026.
ABSTRACT Introduction/Aims Respiratory weakness, typically monitored as vital capacity (VC), is a central feature of amyotrophic lateral sclerosis (ALS). VC is increasingly measured remotely in participants' homes, although in‐clinic assessment remains the standard.
Eric A. Macklin, James D. Berry, Brittney A. Harkey, Lindsay Heyd, Marianne Chase, Hong Yu, Alexander V. Sherman, Derek Dagostino, Gale Kittle, Meghan Hall, Mariah R. Connolly, Kristin Drake, Elisa Giacomelli, Erica Scirocco, Saloni Sharma, Suma Babu, Michael Benatar, Zachary Simmons, Eufrosina Young, Merit E. Cudkowicz, Jeremy Shefner, Sabrina Paganoni, on behalf of the HEALEY ALS Platform Trial Study Group, Eric A. Macklin, Lori B. Chibnik, Douglas Hayden, Po‐Ying Lai, Rachel A. Donahue, Hao‐Wun Chen, Jianing Wang, Melanie Quintana, Benjamin R. Saville, Michelle A. Detry, Joe Marion, Matteo Vestrucci, Anna McGlothlin, Gustavo Alameda, Nithya Mathai, Eduardo Locatelli, Gabriela Lopes, Sabrina Paganoni, Merit Cudkowicz, Doreen Ho, Alexandra McCaffrey, James D. Berry, Suma Babu, Jennifer Scalia, Sarah Luppino, Clotilde Lagier‐Tourenne, Ghazaleh Sadri‐Vakili, Adam Quick, Stephen Kolb, Sarah Heintzman, Senda Ajroud‐Driss, Robert Sufit, April Szymanski, Jonathan Katz, Liberty Jenkins, Daragh Heitzman, Alan Martin, Stanley H. Appel, Simpson) Greene, Jason R. Thonhoff, Sheetal Shroff, Bing Liao, Kevin Felice, Charles Whitaker, Nicholas J. Maragakis, Lora L. Clawson, Alpa Uchil, Kristen M. Riley, JinAe Arneklev, Zachary Simmons, James Grogan, Xiaowei Su, Mansoureh Mamarabadi, Timothy M. Miller, Amber Malcolm, Nicholas Olney, Tracy Bazan, Michael D Weiss, Nassim Rad, Leo H. Wang, Stephen A. Goutman, Eva L. Feldman, Joseph Americo Fernandes, Ezequiel Piccione, Pariwat Thaisetthawatkul, Omar Jawdat, Constantine Farmakidis, Duaa Jabari, Jeffrey Statland, Mamatha Pasnoor, Mazen Dimachkie, Margaret Ayo Owegi, Robert H. Brown, Mehdi Ghasemi, Hajar Houmani, Catherine Douthwright, Kate Daniello, Laura A. Foster, Tuan Vu, Niraja Suresh, Jerrica Farias, I‐Hweii A. Chen, Hristelina Ilieva, Piera Pasinelli, Daniel S. Newman, Ximena Arcila‐Londono, Kara Steijlen, Carlayne E. Jackson, Ratna Bhavaraju‐Sanka, Shafeeq Ladha, Bill Jacobsen, Jourdan Milliard, Robert Bowser, Jeremy M. Shefner, Terry Heiman‐Patterson, Anahita Deboo, James B. Caress, Michael S. Cartwright, Andrea Swenson, Christopher Nance, Ludwig Gutmann, Jinsy Andrews, Julia Yasek, Matthew Harms, Amanda Peltier, Richard Lewis, Matthew Burford, Frank Diaz, Dominic Fee, David Shrilla, Matthew Elliott, Goran Rakocevic, Sarah Jones, Guillermo Solorzano, Richard Bedlack, Xiaoyan Li, Edward J. Kasarskis, Zabeen Mahuwala, Vishakhadatta (Vish) Mathur Kumaraswamy, Lauren Elman, Colin Quinn, Michael Baer, Jeffrey Rosenfeld, David Borg, Karthikeyan Bhuvaneswaran, Jasdeep Kaur, David Walk, Sam Maiser, Seward B. Rutkove, Courtney E. McIlduff, Paul Twydell, Andrew Mundwiler, Eufrosina Young, Jenny A. Meyer, Kristin Johnson, Pooja Rao, Kourosh Rezania, Betty Soliven, Raymond Roos, Namita A. Goyal, Ali A. Habib, Tahseen Mozaffar, Manisha Kak Korb, Jeffrey Mullen, Jeffrey A. Cohen, Elijah Stommel, Nathaniel M Robbins, Michael Benatar, Nathan Carberry, Volkan Granit, Raghav Govindarajan, Vovanti Jones, Jonathan Glass, Christina N. Fournier, Jaimin S. Shah, Bjorn Oskarsson, Said R. Beydoun, Leila Darki, Rodrigo Rodriguez, James P. Wymer, Miguel Chuquilin, Whitney McNeely, Lindsay Zilliox, Montserrat Diaz‐Abad, Peter H. Jin, Chandana Chauhan, Shakti Nayar, Gary L. Pattee, James Bobenhouse, Jennifer Martinez‐Thompson, Nathan P. Staff, Ghazala Hayat, Luisa Arroyave, Abbey Bailey, Jesse Bailey, Victoria Barlow, Allison Bulat, Genevive Changkuon, Marianne Chase, Melissa Cirino, Derek Dagostino, Cristina Deignan, Emma Deirmendjian, Annette De Mattos, Sofia DiStefano, Kristin Drake, Michaela Estes, Kenneth Faulconer, Precious Figueroa‐Szostek, Tessa Garozzo, Brittney A. Harkey, Meredith Gibbons Hasenoehrl, Jennifer Henrique, Natalie Henrique, Samuel Hurwitz, Courtney Igne, Liam Irwin, Katie Jentoft, Boglarka Jordan, Igor Katsovskiy, Olga Kharakozova, Taylor Kolvek, Alexander Korin, Thuong La, Haining Li, Joey Nguyen, Ilya Novak, Ricardo Ortiz, Joe Ostrow, Jaclyn Pagliaro, Jack Palillo, Payal Patel, Janae Patterson, Minh Phan, Najla Popel, Lindsay Pothier, Serena Proueng, Jesse Rosenthal, Alexander V. Sherman, Catherine Small, Natalia Tarasenko, Mirna Thomas, Eric Tustison, Prasha Vigneswaran, Yusra Wahab, Isaac Whitworth, Spencer Wright, Hong Yu, Mariah Connolly, Diana De Santiago, Adrian Felix, Karly Garrett, Meghan Hall, Jenny Hamilton, Kamran Khan, Gale Kittle, Marlee Lovett, Linda Nelson, Marissa Pabon, Diana Rede, Patrick Bolger, Ahmed Fetouh, Joan Woodcook, Cornelia Kamp, Julie Kennedy, Andrew McGarry, Margherita Torti   +269 more
wiley   +1 more source

Edaravone for the Treatment of Motor Neurone Disease: A Critical Review of Approved and Alternative Formulations against a Proposed Quality Target Product Profile

Pharmaceutics
Edaravone is one of two main drugs for treating motor neurone disease (MND). This review proposes a specific quality target product profile (QTPP) for edaravone following an appraisal of the issues accounting for the poor clinical uptake of the approved ...
Riuna O’Neill, Okhee Yoo, Philip Burcham, Lee Yong Lim   +3 more
doaj   +1 more source

Edaravone Preserves Coronary Microvascular Endothelial Function After Ischemia/Reperfusion on the Beating Canine Heart In Vivo

Journal of Pharmacological Sciences, 2007
We examined whether edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a free radical scavenger, exerts its protective effect on coronary microvessels after ischemia/reperfusion (I/R) in vivo.
Renan Sukmawan, Toyotaka Yada, Eiji Toyota, Yoji Neishi, Teruyoshi Kume, Yoshiro Shinozaki, Hidezo Mori, Yasuo Ogasawara, Fumihiko Kajiya, Kiyoshi Yoshida   +9 more
doaj   +1 more source

Edaravone use in acute intracerebral hemorrhage: A systematic review and meta-analysis of randomized controlled trials

Frontiers in Pharmacology, 2022
Background: Edaravone alleviates neurological deficits among patients with intracerebral hemorrhage; however, its effects on mortality and long-term functional outcomes remain unknown.Objective: To assess clinical outcomes associated with edaravone ...
Mingzhen Qin, Mingzhen Qin, Mingzhen Qin, Luda Feng, Luda Feng, Chinyu Yang, Chinyu Yang, Chinyu Yang, Dawei Wei, Dawei Wei, Tingting Li, Tingting Li, Tingting Li, Ping Jiang, Ping Jiang, Ping Jiang, Jinzhi Guan, Jinzhi Guan, Xinyue Zhang, Xinyue Zhang, Xinyi Shi, Xinyi Shi, Xinyi Shi, Ning Liang, Xinxing Lai, Xinxing Lai, Li Zhou, Chi Zhang, Chi Zhang, Ying Gao, Ying Gao, Ying Gao   +31 more
doaj   +1 more source

Exploring Genetic Therapies Targeting Amyotrophic Lateral Sclerosis in Animal Models: A Systematic Review and Meta‐Analysis

The Journal of Gene Medicine, Volume 28, Issue 8, August 2026.
Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease for which there is currently no known cure. This systematic review explores the efficacy of genetic therapies used to target ALS in preclinical studies using in vivo rodent models. Outcomes investigated include the total number of motor neurons, rodent survival, and muscle function
Hannah E. Wedgwood, Richard I. Tuxworth, Zubair Ahmed   +2 more
wiley   +1 more source

Association between edaravone use and activities of daily living in older patients with atherothrombotic stroke: an observational study using Japanese real-world data

BMC Geriatrics
Background Edaravone is marketed in nine countries, although only Japan has approved edaravone for improvement of neurological symptom, disability of activities of daily living (ADL), and functional disability associated with acute stroke.
Yukari Ogawa, Hiroko Akiyama, Takeshi Horii, Kiyoshi Mihara   +3 more
doaj   +1 more source

Mesenchymal Stromal Cell Rejuvenation Strategies to Enhance Clinical Translation in Cell Therapy

Aging Cell, Volume 25, Issue 8, August 2026.
MSC rejuvenation strategies and functional outcomes. Aging‐associated alterations in MSCs, including increased IL‐6/IL‐8 secretion, ROS accumulation, epigenetic drift, and mitochondrial dysfunction, impair stemness. Rejuvenation approaches, epigenetic modulation (VPA, AZAc, OSKM, TERT), metabolic interventions (resveratrol, calcitriol, NMD, asprosin ...
Astrid Sodomaco, Irene Bernardi, Aretha Rambaldi, Pierluigi Lombardi, Maura Rossi, Francesca Paris, Lucia Manzoli, Stefano Ratti, Francesco Alviano   +8 more
wiley   +1 more source

July 2017 ENCALS statement on edaravone [PDF]

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2017
Neurologists of the ENCALS centers throughout Europe have discussed the potential of edaravone as a new therapy for amyotrophic lateral sclerosis (ALS, Motor Neuron Disease, MND) at the ENCALS meeting, 18–20 May 2017, in Ljubljana, Slovenia.\ud \ud In May 2017, the US Food and Drug Administration (FDA) granted a license for the drug known as edaravone (
Al-Chalabi, A., Andersen, P.M., Chandran, S., Chio, A., Corcia, P., Couratier, P., Danielsson, O., de Carvalho, M., Desnuelle, C., Grehl, T., Grosskreutz, J., Holmøy, T., Ingre, C., Karlsborg, M., Kleveland, G., Christoph Koch, J., Koritnik, B., KuzmaKozakiewicz, M., Laaksovirta, H., Ludolph, A., McDermott, C., Meyer, T., Mitre Ropero, B., Mora Pardina, J., Nygren, I., Petri, S., Povedano Panades, M., Salachas, F., Shaw, P., Silani, V., Staaf, G., Svenstrup, K., Talbot, K., Tysnes, O.-B., Van Damme, P., van der Kooi, A., Weber, M., Weydt, P., Wolf, J., Hardiman, O., van den Berg, L.H.   +40 more
openaire   +15 more sources