Results 11 to 20 of about 5,356 (175)
Frontiers in PharmacologyObjectiveThe objective of this study was to systematically assess the clinical efficacy and safety of edaravone dexborneol compared to those of edaravone in treating acute cerebral infarction.MethodsWe searched the PubMed, Cochrane Library, Embase, CBM ...
Yanshuo Shi +6 more
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Generalizability of Edaravone Efficacy. [PDF]
Muscle NerveABSTRACT The pivotal phase 3 trial MCI186‐19 (Study 19) demonstrated the efficacy of intravenous edaravone in slowing functional decline in patients with amyotrophic lateral sclerosis (ALS), leading to United States Food and Drug Administration approval.
Brooks BR +3 more
europepmc +3 more sources
Pharmaceutics, 2021 Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a free radical scavenger approved for the treatment of amyotrophic lateral sclerosis, a fatal neuromuscular disease. Edaravone is administered as an intravenous infusion over 60 min for several treatment
Dong Wook Kang +9 more
doaj +1 more source
Effect of edaravone on pregnant mice and their developing fetuses subjected to placental ischemia
Reproductive Biology and Endocrinology, 2021 Growing evidence indicates that reduced uterine perfusion pressure (RUPP) triggers the cascade of events leading to preeclampsia. Edaravone is a powerful free radical scavenger used for the treatment of ischemia/reperfusion diseases due to its anti ...
Marwa Atallah, Toru Yamashita, Koji Abe
doaj +1 more source
Antioxidants, 2022 Edaravone, the first known free radical scavenger, has demonstrated cellular protective properties in animals and humans. Owing to its antioxidant activity, edaravone modulates oxidative damage in various diseases, especially neurodegenerative diseases ...
Sun Joo Cha, Kiyoung Kim
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Antiviral Effect and Mechanism of Edaravone against Grouper Iridovirus Infection
Viruses, 2023 Singapore grouper iridovirus (SGIV) is a virus with high fatality rate in the grouper culture industry. The outbreak of SGIV is often accompanied by a large number of grouper deaths, which has a great impact on the economy.
Jihui Kuang +8 more
doaj +1 more source
EClinicalMedicine, 2022 Summary: Background: We aimed to evaluate overall survival in US patients with amyotrophic lateral sclerosis (ALS) treated with intravenous (IV) edaravone compared with those not treated with IV edaravone in a real-world setting.
Benjamin Rix Brooks +6 more
doaj +1 more source
Edaravone attenuates sustained pial arteriolar vasoconstriction independently of endothelial function after unclamping of the abdominal aorta in rabbits [PDF]
Korean Journal of Anesthesiology, 2021 Background Cerebral blood flow (CBF) has direct effects on neuronal function and neurocognitive disorders. Oxidative stress from abdominal aortic surgery is important in the pathophysiology of CBF impairment.
Tomohiro Michino +6 more
doaj +1 more source
PLoS ONE, 2014 BackgroundMany of these therapies have been compared against placebos, but have not been directly compared against each other. To evaluate the efficacy and safety of several commonly used drugs for AIS directly or indirectly.MethodsA systematic ...
Bowen Yang +4 more
doaj +1 more source
Edaravone, a Radical Scavenger, Inhibits Mitochondrial Permeability Transition Pore in Rat Brain
Journal of Pharmacological Sciences, 2007 Edaravone, a radical scavenger, prevents ischemia/reperfusion injury in the brain, but the detailed mechanism is not known. This study examines the effect of edaravone on mitochondrial permeability transition pore (PTP) in rat brain.
Yuko Takayasu +6 more
doaj +1 more source