Results 111 to 120 of about 10,879 (246)

Neuroprotective Potential of Curcumin in Neurodegenerative Diseases: Clinical Insights Into Cellular and Molecular Signaling Pathways

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 8, August 2025.
Curcumin regulates several signaling pathways linked to neuroprotection, such as those that reduce oxidative stress, prevent Aβ formation, and decrease neuroinflammation. ABSTRACT Progressive neuronal loss and dysfunction characterize neurodegenerative diseases (NDs) such as Alzheimer's, Parkinson's, and Huntington's diseases, spinal cord injury, and ...
Md. Rezaul Islam, Abdur Rauf, Sumiya Akter, Happy Akter, Md. Ibrahim Khalil Al‐Imran, Md. Naeem Hossain Fakir, Gazi Kaifeara Thufa, Md. Tazul Islam, Hassan A. Hemeg, Waleed Al Abdulmonem, Abdullah S. M. Aljohani, Marcello Iriti   +11 more
wiley   +1 more source

Pre- and Posttreatment With Edaravone Protects CA1 Hippocampus and Enhances Neurogenesis in the Subgranular Zone of Dentate Gyrus After Transient Global Cerebral Ischemia in Rats

ASN Neuro, 2014
Edaravone is clinically used for treatment of patients with acute cerebral infarction. However, the effect of double application of edaravone on neurogenesis in the hippocampus following ischemia remains unknown. In the present study, we explored whether
Shan Lei, Pengbo Zhang, Weisong Li, Ming Gao, Xijing He, Juan Zheng, Xu Li, Xiao Wang, Ning Wang, Junfeng Zhang, Cunfang Qi, Haixia Lu, Xinlin Chen, Yong Liu   +13 more
doaj   +1 more source

Intravenous edaravone treatment in ALS and survival: An exploratory, retrospective, administrative claims analysis

EClinicalMedicine, 2022
Summary: Background: We aimed to evaluate overall survival in US patients with amyotrophic lateral sclerosis (ALS) treated with intravenous (IV) edaravone compared with those not treated with IV edaravone in a real-world setting.
Benjamin Rix Brooks, James D. Berry, Malgorzata Ciepielewska, Ying Liu, Gustavo Suarez Zambrano, Jeffrey Zhang, Melissa Hagan   +6 more
doaj  

Edaravone combined with Schwann cell transplantation may repair spinal cord injury in rats

Neural Regeneration Research, 2015
Edaravone has been shown to delay neuronal apoptosis, thereby improving nerve function and the microenvironment after spinal cord injury. Edaravone can provide a favorable environment for the treatment of spinal cord injury using Schwann cell ...
Shu-quan Zhang, Min-fei Wu, Zhe Piao, Jin Yao, Ji-hai Li, Xin-gang Wang, Jun Liu   +6 more
doaj   +1 more source

Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases

BioEssays, Volume 47, Issue 7, July 2025.
Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley   +1 more source

Evaluation of edaravone against radiation-induced oral mucositis in mice

Journal of Pharmacological Sciences, 2015
Oral mucositis induced by radiotherapy for cancers of the head and neck reduce the quality of life of patients. However, effective therapeutic agents are lacking. Symptomatic treatment involves local anesthesia and analgesia.
Noriko Nakajima, Shinichi Watanabe, Takeshi Kiyoi, Akihiro Tanaka, Katsuya Suemaru, Hiroaki Araki   +5 more
doaj   +1 more source

An Expanded Access Protocol of RNS60 in Amyotrophic Lateral Sclerosis

Muscle &Nerve, Volume 72, Issue 1, Page 124-129, July 2025.
ABSTRACT Aims RNS60 is an investigational product in clinical development for amyotrophic lateral sclerosis (ALS). RNS60 slowed disease progression in the ALS SOD1G93A mouse model and was safe and well tolerated both in an open‐label pilot study and a randomized, placebo‐controlled, multicenter phase 2 trial in people living with ALS.
Grace Addy, Erica Scirocco, Dario Gelevski, Margot Rohrer, Aimee Roderick, Mary McCormack, Anat Weiss Sadan, Jennifer Scalia, Neil Parikh, Elisa Giacomelli, Matteo Locatelli, Dylan V. Neel, Derek D'Agostino, Alex Leite, Hong Yu, Alexander V. Sherman, Jarrad Mock, Andreas Kalmes, Sarah Luppino, Suma Babu, James Berry, Merit Cudkowicz, Sabrina Paganoni   +22 more
wiley   +1 more source

A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy? [PDF]

Expert Opinion on Pharmacotherapy, 2010
Edaravone (Radicut) is a free radical scavenger marketed in Japan by Mitsubishi Tanabe Pharma Corp. to treat acute ischemic stroke (AIS) patients presenting within 24 h of the attack. Injectable edaravone ampoules (30 mg b.i.d., i.v., 14 days) were first approved on 23 May 2001. On 19 January 2010, as a new innovation, the Radicut BAG (Intravenous BAG)
openaire   +3 more sources

Predictive Analysis of Amyotrophic Lateral Sclerosis Progression and Mortality in a Clinic Cohort From Singapore

Muscle &Nerve, Volume 72, Issue 1, Page 71-81, July 2025.
ABSTRACT Introduction There is currently no comprehensive Amyotrophic Lateral Sclerosis (ALS) patient database in Singapore comparable to those available in Europe and the United States. We established the Singapore ALS registry (SingALS) to draw meaningful inferences about the ALS population in Singapore through developing statistical and machine ...
Ian Qian Xu, Ling Guo, Jing Xu, Stella Setiawan, Xiao Deng, Yew Long Lo, Josiah Yui Huei Chai, Zachary Simmons, Savitha Ramasamy, Crystal Jing Jing Yeo   +9 more
wiley   +1 more source

Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications

CNS Neuroscience &Therapeutics, Volume 31, Issue 7, July 2025.
Microglia interact with oxidative stress, reactive astrocytes, neuronal damage, neuroinflammation, synaptic dysfunction, mitochondrial dysfunction, epigenetic modifications, and blood–brain barrier disruption, playing a critical role in the pathophysiology of perioperative neurocognitive disorders (PND).
Xizhen Liu, Anke Zhang
wiley   +1 more source