Results 21 to 30 of about 7,855 (224)
Antiviral Effect and Mechanism of Edaravone against Grouper Iridovirus Infection
Viruses, 2023 Singapore grouper iridovirus (SGIV) is a virus with high fatality rate in the grouper culture industry. The outbreak of SGIV is often accompanied by a large number of grouper deaths, which has a great impact on the economy.
Jihui Kuang +8 more
doaj +1 more source
Edaravone May Prevent Ferroptosis in ALS [PDF]
Current Drug Targets, 2020 Radicava™ (Edaravone) was approved the Food and Drug Administration (FDA) as a new treatment for amyotrophic lateral sclerosis (ALS). Edaravone is a synthetic antioxidant that specifically targets oxidative damage interacting with lipid radicals in the cell.
Snežana Spasić +6 more
openaire +5 more sources
Current Issues in Molecular Biology, 2023 The appropriate dosage of edaravone—a radioprotective agent—and its effect on tumors are unknown. This study evaluated the effects of edaravone on intestinal injuries and tumors in mice induced by whole body X-ray irradiation.
Terufumi Kawamoto, Keisuke Sasai
doaj +1 more source
Edaravone, a Radical Scavenger, Inhibits Mitochondrial Permeability Transition Pore in Rat Brain
Journal of Pharmacological Sciences, 2007 Edaravone, a radical scavenger, prevents ischemia/reperfusion injury in the brain, but the detailed mechanism is not known. This study examines the effect of edaravone on mitochondrial permeability transition pore (PTP) in rat brain.
Yuko Takayasu +6 more
doaj +1 more source
EClinicalMedicine, 2022 Summary: Background: We aimed to evaluate overall survival in US patients with amyotrophic lateral sclerosis (ALS) treated with intravenous (IV) edaravone compared with those not treated with IV edaravone in a real-world setting.
Benjamin Rix Brooks +6 more
doaj +1 more source
Long-term effects of edaravone on survival of patients with amyotrophic lateral sclerosis
eNeurologicalSci, 2018 Background and purpose: Oxidative stress has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Edaravone, a free radical scavenger, was approved as a therapeutic drug for ALS in 2015 in Japan.
Masamitsu Okada +5 more
doaj +1 more source
Application of a free radical scavenger edaravone in patients with hemorrhagic stroke
Infusion & Chemotherapy, 2021 BACKGROUND. The free radical scavenger edaravone helps to reduce the area of ischemic injury and improve the longterm effects of stroke, and is therefore widely used in the treatment of ischemic stroke.
O.A. Halushko
doaj +1 more source
Turkish Journal of Vascular Surgery, 2023 Aim: Lower limb ischemia/reperfusion leads to distant organ dysfunction, notably affecting the lungs, resulting in respiratory failure and significant morbidity and mortality.
Mehmet Ceber +4 more
doaj +1 more source
Pharmaceuticals, 2021 Reports on the long-term survival effect of edaravone, which was approved for the treatment of amyotrophic lateral sclerosis (ALS) in 2015 in Japan, are rare.
Hideki Houzen +5 more
doaj +1 more source
Stable BF2 Boracycles as Versatile Reagents for Selective Ortho C–H Functionalization
Angewandte Chemie, EarlyView.We report a robust, metal‐free and scalable synthesis of stable BF2 boracycles via directed ortho CH borylation, delivering isolable, shelf‐stable reagents without chromatographic purification. These BF2 boracycles exhibit unique and tunable reactivity, enabling highly selective ipso‐functionalization across a broad range of transformations.
Ganesh H. Shinde +11 more
wiley +2 more sources