Results 51 to 60 of about 7,855 (224)

Safety of butylphthalide and edaravone in patients with ischemic stroke: a multicenter real-world study [PDF]

, 2023
Shu‐Xian Lyu, Dong-Fang QIAN, Yufei Feng, Chengwu Shen, Lubo Guo, Jian-Tao LYU, Pengfei Jin, Ting Li, Siyuan Tan, Zixuan Zhang, Lin Huang, Xue Zhong, Le‐Qun Su, Xin Hu, Xin Huang, Xueyan Cui   +15 more
openalex   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Association between edaravone use and activities of daily living in older patients with atherothrombotic stroke: an observational study using Japanese real-world data

BMC Geriatrics
Background Edaravone is marketed in nine countries, although only Japan has approved edaravone for improvement of neurological symptom, disability of activities of daily living (ADL), and functional disability associated with acute stroke.
Yukari Ogawa, Hiroko Akiyama, Takeshi Horii, Kiyoshi Mihara   +3 more
doaj   +1 more source

Edaravone use in acute intracerebral hemorrhage: A systematic review and meta-analysis of randomized controlled trials

Frontiers in Pharmacology, 2022
Background: Edaravone alleviates neurological deficits among patients with intracerebral hemorrhage; however, its effects on mortality and long-term functional outcomes remain unknown.Objective: To assess clinical outcomes associated with edaravone ...
Mingzhen Qin, Mingzhen Qin, Mingzhen Qin, Luda Feng, Luda Feng, Chinyu Yang, Chinyu Yang, Chinyu Yang, Dawei Wei, Dawei Wei, Tingting Li, Tingting Li, Tingting Li, Ping Jiang, Ping Jiang, Ping Jiang, Jinzhi Guan, Jinzhi Guan, Xinyue Zhang, Xinyue Zhang, Xinyi Shi, Xinyi Shi, Xinyi Shi, Ning Liang, Xinxing Lai, Xinxing Lai, Li Zhou, Chi Zhang, Chi Zhang, Ying Gao, Ying Gao, Ying Gao   +31 more
doaj   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Phase 3b Extension Study MT‐1186‐A04 to Evaluate the Continued Efficacy and Safety of Edaravone Oral Suspension for Up to an Additional 48 Weeks in Patients With Amyotrophic Lateral Sclerosis

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims An On/Off dosing regimen of intravenous (IV) edaravone and edaravone oral suspension is currently approved in the US for treatment of amyotrophic lateral sclerosis (ALS). Placebo‐controlled clinical trials showed that IV edaravone slows physical functional decline.
Angela Genge, Jeffrey Rothstein, Shari De Silva, Lorne Zinman, Marvin Chum, Adriano Chiò, Gen Sobue, Masashi Aoki, Hiide Yoshino, Manabu Doyu, Daniel Selness, Vesna Todorovic, Manabu Hirai, Nissim Sasson, Fumihiro Takahashi, Michelle Cecić, Art Wamil, Stephen Apple   +17 more
wiley   +1 more source

Edaravone protects endotoxin-induced liver injury by inhibiting apoptosis and reducing proinflammatory cytokines

Brazilian Journal of Medical and Biological Research, 2014
Studies have shown that edaravone may prevent liver injury. This study aimed to investigate the effects of edaravone on the liver injury induced by D-galactosamine (GalN) and lipopolysaccharide (LPS) in female BALB/c mice.
L. Zong, Q.H. Yu, Y.X. Du, X.M. Deng
doaj   +1 more source

Tui Na Acupressure Modulates Treg Immunosuppression via FoxP3/mTORC1 Signalling in ALS Mice

Immunology, EarlyView.
The proposed mechanism by which Tui Na acupressure improves motor and cognitive dysfunction in ALS mice by activating the FoxP3/mTORC1 pathway. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease driven by neuroinflammation, where regulatory T cell (Treg) dysfunction exacerbates immune imbalance.
Jie Han, Xi Xu, Yan Zhao, Yao Xiao, Fei Huang, Jing Zhou, Hai Huang, Guiqian Wang   +7 more
wiley   +1 more source

Evaluation of the Anti-apoptotic and Anti-cytotoxic Effect of Epicatechin Gallate and Edaravone on SH-SY5Y Neuroblastoma Cells

Basic and Clinical Neuroscience, 2019
Introduction: Parkinson disease (PD) is the second most common neurodegenerative disease affecting older individuals with signs of motor disability and cognitive impairment. Epicatechin (EC) and edaravone have neuroprotective effects most probably due to
Mohammad Shokrzadeh, Hashem Javanmard, Golpar Golmohammad Zadeh, Hossein Asgarian Omran, Mona Modanlou, Saeed Yaghubi-Beklar, Ramin Ataee   +6 more
doaj  

Synergy of combined tPA-edaravone therapy in experimental thrombotic stroke. [PDF]

PLoS ONE, 2014
Edaravone, a potent antioxidant, may improve thrombolytic therapy because it benefits ischemic stroke patients on its own and mitigates adverse effects of tissue plasminogen activator (tPA) in preclinical models.
Yu-Yo Sun, Yury M Morozov, Dianer Yang, Yikun Li, R Scott Dunn, Pasko Rakic, Pak H Chan, Koji Abe, Diana M Lindquist, Chia-Yi Kuan   +9 more
doaj   +1 more source