Results 51 to 60 of about 14,917 (287)
Inhibitory Effects of Edaravone, a Free Radical Scavenger, on Cytokine-induced Hyperpermeability of Human Pulmonary Microvascular Endothelial Cells:A Comparison with Dexamethasone and Nitric Oxide Synthase Inhibitor [PDF]
Lung hyperpermeability affects the development of acute respiratory distress syndrome (ARDS), but therapeutic strategies for the control of microvascular permeability have not been established.
Fujii, Yousuke+8 more
core +1 more source
Stroke is the leading cause of disability and death. When blood flow is restored after prolonged ischemia and hypoxia, it leads to excessive production of reactive oxygen species (ROS), increased local inflammation, and apoptosis, which are the cause of ...
Lili Xu+6 more
semanticscholar +1 more source
Edaravone Derivatives Containing NO-Donor Functions
A new series of polyvalent drugs obtained by joining edaravone with NO-donor moieties is described. All compounds display high antioxidant power together with NO-dependent vasodilator properties. The analysis of a number of molecular descriptors shows that the antioxidant activity, which is tightly linked to the presence of the edaravone substructure ...
CHEGAEV, Konstantin+8 more
openaire +5 more sources
This study explores the edaravone solubility space encompassing both neat and binary dissolution media. Efforts were made to reveal the inherent concentration limits of common pure and mixed solvents.
Maciej Przybyłek+4 more
semanticscholar +1 more source
Predicting Progression in Parkinson's Disease Using Baseline and 1-Year Change Measures. [PDF]
BackgroundImproved prediction of Parkinson's disease (PD) progression is needed to support clinical decision-making and to accelerate research trials.ObjectivesTo examine whether baseline measures and their 1-year change predict longer-term progression ...
Arnedo, Vanessa+15 more
core +1 more source
Background Bone dysfunction is a crucial problem that occurs during rheumatoid arthritis (RA) disease. Osteoclast plays a significant role in bone resorption and osteoclast differentiation and its enhancement of bone destruction.
Jichao Liu+4 more
semanticscholar +1 more source
Experimental Treatment with Edaravone in a Mouse Model of Spinocerebellar Ataxia 1
Edaravone is a mitochondrially targeted drug with a suggested capability to modify the course of diverse neurological diseases. Nevertheless, edaravone has not been tested yet in the context of spinocerebellar ataxia 1 (SCA1), an incurable ...
Martina Sucha+9 more
semanticscholar +1 more source
Clinical Effects of Edaravone in Stroke: A Review [PDF]
Anisha Thomas+3 more
openalex +3 more sources
ObjectiveTo establish an ischemia-reperfusion model in cynomolgus macaques and to analyse the effects of edaravone intervention.MethodsA total of fifteen adult male cynomolgus macaques were randomly divided into three groups: sham operation (Sham group ...
PAN Mengxian+8 more
doaj +1 more source
In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in mice [PDF]
Detection and protection of apoptosis, autophagy and neurovascular unit (NVU) are essentially important in understanding and treatment for ischemic stroke patients.
Abe+35 more
core +1 more source