Results 51 to 60 of about 14,917 (287)

Inhibitory Effects of Edaravone, a Free Radical Scavenger, on Cytokine-induced Hyperpermeability of Human Pulmonary Microvascular Endothelial Cells:A Comparison with Dexamethasone and Nitric Oxide Synthase Inhibitor [PDF]

open access: yes, 2015
Lung hyperpermeability affects the development of acute respiratory distress syndrome (ARDS), but therapeutic strategies for the control of microvascular permeability have not been established.
Fujii, Yousuke   +8 more
core   +1 more source

Edaravone dexborneol protects cerebral ischemia reperfusion injury through activating Nrf2/HO‐1 signaling pathway in mice

open access: yesFundamental & Clinical Pharmacology, 2022
Stroke is the leading cause of disability and death. When blood flow is restored after prolonged ischemia and hypoxia, it leads to excessive production of reactive oxygen species (ROS), increased local inflammation, and apoptosis, which are the cause of ...
Lili Xu   +6 more
semanticscholar   +1 more source

Edaravone Derivatives Containing NO-Donor Functions

open access: yesJournal of Medicinal Chemistry, 2008
A new series of polyvalent drugs obtained by joining edaravone with NO-donor moieties is described. All compounds display high antioxidant power together with NO-dependent vasodilator properties. The analysis of a number of molecular descriptors shows that the antioxidant activity, which is tightly linked to the presence of the edaravone substructure ...
CHEGAEV, Konstantin   +8 more
openaire   +5 more sources

Exploring the Solubility Limits of Edaravone in Neat Solvents and Binary Mixtures: Experimental and Machine Learning Study

open access: yesMolecules, 2023
This study explores the edaravone solubility space encompassing both neat and binary dissolution media. Efforts were made to reveal the inherent concentration limits of common pure and mixed solvents.
Maciej Przybyłek   +4 more
semanticscholar   +1 more source

Predicting Progression in Parkinson's Disease Using Baseline and 1-Year Change Measures. [PDF]

open access: yes, 2019
BackgroundImproved prediction of Parkinson's disease (PD) progression is needed to support clinical decision-making and to accelerate research trials.ObjectivesTo examine whether baseline measures and their 1-year change predict longer-term progression ...
Arnedo, Vanessa   +15 more
core   +1 more source

Anti-Arthritic Effect of Edaravone Against Complete Freund Adjuvant Induced Arthritis via Osteoclast Differentiation and HIF-1α–VEGF–ANG-1 Axis

open access: yesDrug Design, Development and Therapy, 2023
Background Bone dysfunction is a crucial problem that occurs during rheumatoid arthritis (RA) disease. Osteoclast plays a significant role in bone resorption and osteoclast differentiation and its enhancement of bone destruction.
Jichao Liu   +4 more
semanticscholar   +1 more source

Experimental Treatment with Edaravone in a Mouse Model of Spinocerebellar Ataxia 1

open access: yesInternational Journal of Molecular Sciences, 2023
Edaravone is a mitochondrially targeted drug with a suggested capability to modify the course of diverse neurological diseases. Nevertheless, edaravone has not been tested yet in the context of spinocerebellar ataxia 1 (SCA1), an incurable ...
Martina Sucha   +9 more
semanticscholar   +1 more source

Clinical Effects of Edaravone in Stroke: A Review [PDF]

open access: goldIndian Journal of Pharmacy Practice, 2019
Anisha Thomas   +3 more
openalex   +3 more sources

Establishment of Ischemia-Reperfusion Model in Cynomolgus Macaques and Effects of Edaravone Intervention

open access: yesShiyan dongwu yu bijiao yixue, 2023
ObjectiveTo establish an ischemia-reperfusion model in cynomolgus macaques and to analyse the effects of edaravone intervention.MethodsA total of fifteen adult male cynomolgus macaques were randomly divided into three groups: sham operation (Sham group ...
PAN Mengxian   +8 more
doaj   +1 more source

In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in mice [PDF]

open access: yes, 2011
Detection and protection of apoptosis, autophagy and neurovascular unit (NVU) are essentially important in understanding and treatment for ischemic stroke patients.
Abe   +35 more
core   +1 more source

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