Results 71 to 80 of about 5,356 (175)

Edaravone combined with Schwann cell transplantation may repair spinal cord injury in rats

Neural Regeneration Research, 2015
Edaravone has been shown to delay neuronal apoptosis, thereby improving nerve function and the microenvironment after spinal cord injury. Edaravone can provide a favorable environment for the treatment of spinal cord injury using Schwann cell ...
Shu-quan Zhang, Min-fei Wu, Zhe Piao, Jin Yao, Ji-hai Li, Xin-gang Wang, Jun Liu   +6 more
doaj   +1 more source

Effects of Edaravone on Singlet Oxygen Released From Activated Human Neutrophils

Journal of Pharmacological Sciences, 2007
The effects of edaravone, a curative agent for acute brain infarction, on singlet oxygen (1O2) released from activated human neutrophils were examined, and the effects were compared to those of histidine, a 1O2 singlet oxygen scavenger.
Piyanart Sommani, Toshiyuki Arai, Kouhei Yamashita, Takashi Miyoshi, Hiroko Mori, Masataka Sasada, Keisuke Makino   +6 more
doaj   +1 more source

IL6 and WNK2 polymorphisms and prognosis in patients with intracerebral hemorrhage receiving edaravone

Journal of Stroke and Cerebrovascular Diseases
Objective: Edaravone is utilized in intra-cerebral hemorrhage (ICH) patients for years, while personalized variances were observed in clinic. To explore the precision medicine strategy for Edaravone, this study investigated the association between ...
Yu-Peng Zhang, Sai Wang, Tian-Xing Yao, Xue-Lun Zou, Si Li, Lei Chen, Xiang-Bin Zhang, Jun-You Chen, Yi Zeng, Le Zhang   +9 more
doaj   +1 more source

Edaravone in Digestive Diseases – A Narrative Review

Drug Design, Development and Therapy
Digestive diseases represent a diverse and complex group of systemic disorders, often marked by intricate pathogenic mechanisms and substantial rates of morbidity, disability, and mortality. While effective therapies exist for certain conditions, such as peptic ulcers, gastrointestinal hemorrhage, and viral hepatitis, many others remain difficult to ...
Haiyun Lei, Mingchun Wang, Ma Huang, Xiaoyun Fu   +3 more
openaire   +2 more sources

Edaravone: A new drug approved for ALS

Cell, 2017
Amyotrophic lateral sclerosis (ALS) is a progressive, adult onset neurodegenerative disease that is always fatal. The history of ALS drug discovery is fraught with many stops and starts. It took 22 years after the FDA approval of the anti-excitotoxic drug Riluzole before another drug was found to be effective in altering ALS progression: the anti ...
openaire   +2 more sources

Effect of edaravone on synaptic damage in Alzheimer's disease via Rho/ROCK signaling

Pakistan Journal of Pharmaceutical Sciences
Background: Edaravone can reduce damage to brain cells in a variety of ways. Rho/ROCK signaling is involved in Alzheimer's disease. Objectives: This study uses AD cell models to explore edaravone’s effect on AD nerve synapse damage.
Yuejun Li, Qiuyue Lai, Qiong Li, Yixie Fan   +3 more
doaj   +1 more source

ePoster

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

Longer disease progression milestone-free time in people with amyotrophic lateral sclerosis treated versus not treated with intravenous edaravone: results from an administrative claims analysis

Journal of Comparative Effectiveness Research
Aim: To estimate time-to-progression milestones in people with amyotrophic lateral sclerosis (PALS) treated versus not treated with intravenous (IV) edaravone (Radicava R IV, Mitsubishi Tanabe Pharma America [MTPA], hereafter ”IV edaravone”) in a real ...
James D Berry, Melissa Hagan, Jeffrey Zhang, Ying Liu, Malgorzata Ciepielewska   +4 more
doaj   +1 more source

Protective Effect of Edaravone Against Cyclosporine-Induced Chronic Nephropathy Through Antioxidant and Nitric Oxide Modulating Pathways in Rats

Iranian Journal of Medical Sciences, 2017
Background: Cyclosporine A (CsA) is an immunosuppressant with therapeutic indications in various immunological diseases; however, its use is associated with chronic nephropathy. Oxidative stress has a crucial role in CsA-induced nephrotoxicity.
Elahe Sattarinezhad, Mohammad Reza Panjehshahin, Simin Torabinezhad, Eskandar Kamali-Sarvestani, Shirin Farjadian, Fatema Pirsalami, Leila Moezi   +6 more
doaj  

Adverse events in different administration routes of Edaravone: A pharmacovigilance study based on the FDA adverse event reporting system. [PDF]

PLoS One
Ge D, Wu L, Yang J, Sun J, Wang J, Wang J, Song H, Wei R, Xu Z, Zhao B, Sun R, Wang Y.   +11 more
europepmc   +1 more source