Results 91 to 100 of about 429,051 (306)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Algebraic and tropical curves: comparing their moduli spaces [PDF]

, 2011
We construct the moduli space for equivalence classes of n-pointed tropical curves of genus g, together with its compactification given by weighted tropical curves, and establish some of its basic topological properties.
Caporaso, Lucia
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Dimensionality of social networks using motifs and eigenvalues

, 2014
We consider the dimensionality of social networks, and develop experiments aimed at predicting that dimension. We find that a social network model with nodes and links sampled from an $m$-dimensional metric space with power-law distributed influence ...
Bonato, Anthony, Gleich, David F., Kim, Myunghwan, Mitsche, Dieter, Prałat, Paweł, Tian, Amanda, Young, Stephen J.   +6 more
core   +3 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

FEBS Open Bio, EarlyView.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó, Eszter Nagy‐Kanta, Soma Varga, Edit Andrea Jáger, Csaba István Pongor, Mária Laki, András József Laki, Zoltán Gáspári   +7 more
wiley   +1 more source

The Traveling Salesman Problem: Low-Dimensionality Implies a Polynomial Time Approximation Scheme

, 2015
The Traveling Salesman Problem (TSP) is among the most famous NP-hard optimization problems. We design for this problem a randomized polynomial-time algorithm that computes a (1+eps)-approximation to the optimal tour, for any fixed eps>0, in TSP ...
Abraham I., Arora S., Assouad P., Bartal Y., Bartal Y., Bartal Y., Chan T-H. H., Chan T-H. H., Czumaj A., Czumaj A., Fakcharoenphol J., Gao J., Gottlieb L.-A., Gottlieb L.-A., Gottlieb L.-A., Gupta A., J. S., Lampis M., Lee-Ad Gottlieb, Rao S. B., Robert Krauthgamer, Talwar K., Yair Bartal   +22 more
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Mixed metric dimension over (edge) corona products

AKCE International Journal of Graphs and Combinatorics
A subset S of V(G) is called a mixed resolving set for G if, for every two distinct elements x and y of [Formula: see text], there exists [Formula: see text] such that [Formula: see text].
M. Korivand, K. Khashyarmanesh, M. Tavakoli   +2 more
doaj   +1 more source

The Vertex-Edge Resolvability of Some Wheel-Related Graphs

Journal of Mathematics, 2021
A vertex w∈VH distinguishes (or resolves) two elements (edges or vertices) a,z∈VH∪EH if dw,a≠dw,z. A set Wm of vertices in a nontrivial connected graph H is said to be a mixed resolving set for H if every two different elements (edges and vertices) of H ...
Bao-Hua Xing, Sunny Kumar Sharma, Vijay Kumar Bhat, Hassan Raza, Jia-Bao Liu   +4 more
doaj   +1 more source