Results 91 to 100 of about 253,596 (293)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

On Resolvability- and Domination-Related Parameters of Complete Multipartite Graphs

Mathematics, 2022
Graphs of order n with fault-tolerant metric dimension n have recently been characterized.This paper points out an error in the proof of this characterization. We show that the complete multipartite graphs also have the fault-tolerant metric dimension n,
Sakander Hayat, Asad Khan, Yubin Zhong
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A notion of geometric complexity and its application to topological rigidity

, 2010
We introduce a geometric invariant, called finite decomposition complexity (FDC), to study topological rigidity of manifolds. We prove for instance that if the fundamental group of a compact aspherical manifold M has FDC, and if N is homotopy equivalent ...
Guentner, Erik, Tessera, Romain, Yu, Guoliang   +2 more
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

The Traveling Salesman Problem: Low-Dimensionality Implies a Polynomial Time Approximation Scheme

, 2015
The Traveling Salesman Problem (TSP) is among the most famous NP-hard optimization problems. We design for this problem a randomized polynomial-time algorithm that computes a (1+eps)-approximation to the optimal tour, for any fixed eps>0, in TSP ...
Abraham I., Arora S., Assouad P., Bartal Y., Bartal Y., Bartal Y., Chan T-H. H., Chan T-H. H., Czumaj A., Czumaj A., Fakcharoenphol J., Gao J., Gottlieb L.-A., Gottlieb L.-A., Gottlieb L.-A., Gupta A., J. S., Lampis M., Lee-Ad Gottlieb, Rao S. B., Robert Krauthgamer, Talwar K., Yair Bartal   +22 more
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

The Simultaneous Metric Dimension of Families Composed by Lexicographic Product Graphs

, 2015
Let ${\mathcal G}$ be a graph family defined on a common (labeled) vertex set $V$. A set $S\subseteq V$ is said to be a simultaneous metric generator for ${\cal G}$ if for every $G\in {\cal G}$ and every pair of different vertices $u,v\in V$ there exists
Estrada-Moreno, Alejandro, Ramirez-Cruz, Yunior, Rodriguez-Velazquez, Juan A.   +2 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Unique identification and domination of edges in a graph: The vertex-edge dominant edge metric dimension [PDF]

, 2022
H. M. Ikhlaq, Seemab Hayat, Hafiz Muhammad Afzal Siddiqui   +2 more
openalex   +1 more source