Results 191 to 200 of about 4,189,347 (339)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Research edition [PDF]

International Journal of Stroke, 2018
openaire   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Do People Get the Friends They Want? A Cross-Cultural Investigation. [PDF]

Int J Psychol
Apostolou M, Sullman M, Ayers JD, Błachnio A, Choubisa R, Gadelrab HF, Hill T, Kamble S, Lisun Y, Manrique-Millones D, Millones-Rivalles R, Ohtsubo Y, Przepiórka A, Tekeş B, Cruz GV, Wang Y, Watanabe Y, Ghorbani A, Shahrour G.   +18 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Interpretability of an FDA-authorized AI/ML sepsis diagnostic tool improved by SHAP values. [PDF]

JAMIA Open
Watson GL, Staples G, Carver R, Bhargava A, López-Espina C, Schmalz L, Ali F, Antkowiak PS, Azad S, Berghea R, Chawla L, Crisp M, Dagan A, Davila F, Davila H, DeMarco C, Doodlesack A, Espinosa A, Evans NS, Ezekiel C, Friederich A, Gosai F, Halalau A, Iyer K, Kravitz MS, Kurtzman N, Lee JH, Maddens N, Malkani R, Mayer S, Oke V, Palagiri AV, Patel R, Raghavakurup L, Raouf S, Reseland E, Sadaka F, Sarma D, Smith S, Shvilkina T, Sims MD, Singh S, Stenson BA, Syed A, Tafa M, Thomas K, Zhao SD, Zhu R, Bashir R, Reddy B, Shapiro NI.   +50 more
europepmc   +1 more source

Edit compactness [PDF]

Nature Plants, 2020
openaire   +2 more sources

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Two codes of RNA editing by deamination in human diseases. [PDF]

Exp Mol Med
Min DJ, Lee S, Lee YS, Cho J.
europepmc   +1 more source