Results 291 to 300 of about 2,720,692 (363)

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Sovereign AI supercomputers: a global landscape review of unprecedented biomedical research infrastructure. [PDF]

Front Artif Intell
Yang L, Bryan ME, Veiga E, Lowenhoff I, Wan A, Mina I, Allen T, Alfaro JA, Bloomfield G, Beach J, Dahlgren K, Davis NK, Fontana E, Gennatas S, Ghafoor Q, Housseau F, Lubelski D, Zhang Z, Hancock M, Ince W, James D, Khan S, Kunene V, McGrane J, Millen GC, Moxley-Wyles B, Narganes-Carlon D, Payne M, Ross PJ, Roux R, Rowe M, Lee R, Lee JSH, Liu JKH, Aggarwal D, Teoh ABS, Thirlwell C, Tilby M, Symeonides S, Watts I, Agus DB, Ono SJ, Elliott T, Calleja P, Lee LYW.   +44 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Sarcomatoid Transformation of Pulmonary Mucinous Adenocarcinoma as a Mechanism of Immunotherapy Resistance. [PDF]

Thorac Cancer
Yanai K, Tanaka T, Kimura K, Hirose S, Watanabe H, Masuda T, Suzuki R, Kushiro K, Yanagimura N, Kondo S, Nozaki K, Saida Y, Sato M, Watanabe S, Umezu H, Hagiwara K, Kikuchi T.   +16 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Escalation to transplantation in refractory stone heart syndrome: a case report of advanced mechanical circulatory support failure. [PDF]

J Cardiothorac Surg
Holst T, Hanke J, Poyanmehr R, Hinteregger M, Schmitto JD, Dogan G, Avsar M, Weymann A, Ruhparwar A, Schmack B.   +9 more
europepmc   +1 more source

EXPRESSION OF CONCERN: A Newly Identified 45‐kDa JAK2 Variant with an Altered Kinase Domain Structure Represents a Novel Mode of JAK2 Kinase Inhibitor Resistance

Molecular Oncology, EarlyView.
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Feasibility of integrating genetic risk and digital health tools for cardiovascular prevention: the FitPreV protocol. [PDF]

Front Public Health
Tona DM, Porcelli M, Di Pumpo M, Cuoco F, Cuoco MF, Terenzi L, Antonaci L, Maggiori E, Colletti R, Guiducci E, Mammucari M, Paoletti F, Pasca G, Marra GA, Carbone D, Pasciuto T, Sanna T, Liuzzo G, Franceschini E, Villarini A, Pocetta G, de Waure C, Boccia S, Pastorino R.   +23 more
europepmc   +1 more source

SMARCAL1 is a new osteosarcoma predisposition gene. [PDF]

J Natl Cancer Inst
Rafati M, Guenther LM, Egolf LE, Gianferante M, Kim J, Wang K, Zhu B, Spector LG, Anderson N, Janeway KA, Barkauskas DA, Hawkins DS, Patiño-Garcia A, Lupo PJ, Scheurer ME, Morton L, Armstrong GT, Sapkota Y, Gramatges MM, Serra M, Hattinger C, Scotlandi K, Andrulis IL, Wunder JS, Ballinger ML, Thomas DM, Yeager M, Dean M, Stewart DR, Vogt A, Liu J, Hicks BD, Huang WY, Landi MT, Lori A, Diver WR, Savage SA, Chanock SJ, Mirabello L.   +38 more
europepmc   +1 more source