Results 51 to 60 of about 318,622 (316)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Classroom assessment techniques: an assessment and student evaluation method [PDF]

, 2012
Some of the challenges that face Higher Education are how to ensure that assessment is meaningful and that feedback is prompt in order to promote learning.
Walker, Dawn-Marie
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Evaluating Students' Academic Resilience in Chemistry Learning: Insights from a Rasch Model Analysis

Indonesian Journal on Learning and Advanced Education (IJOLAE)
Teaching chemistry is a complex subject that requires a certain level of knowledge and skills to understand. Students must overcome this challenge because teaching chemistry involves abstract ideas (atoms, molecules, and electrons) and principles, laws ...
Desfi Annisa, Hari Sutrisno, Endang Widjajanti Laksono, Sri Novita Yanda   +3 more
doaj   +1 more source

Pharmacoeconomic Analysis of Using Different Types of Monofocal Intraocular Lenses for Cataract Surgery in Russia

Oftalʹmologiâ, 2019
Purpose: To perform cost-effectiveness analysis of using different types of monofocal intraocular lenses (IOL) for cataract surgery in adults in Russian Federation. Materials and methods.
I. S. Krysanov, V. S. Krysanova, V. Yu. Ermakova   +2 more
doaj   +1 more source

Utilization of ChatGPT in educational environmental research: Assessing teachers’ evaluation skills on AI-generated data for educational environmental research

Journal of Teacher Development and Education
The increasing use of Artificial Intelligence (AI) in education presents new challenges, particularly in evaluating the credibility of AI-generated content. This study explores the attitudes and evaluative skills of 279 in-service primary and secondary teachers in assessing AI-generated information on urban heatwaves, as a climate-related issue.
Maria Christoforaki, Evangelia Mavrikaki, Apostolia Galani   +2 more
openaire   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Procedures for Improving Self-report Measurements to Capture Behavior Change: An Illustration

Journal of Human Sciences and Extension, 2020
Programs utilizing research-tested evaluation tools can help identify effective educational strategies and document program effectiveness and impact. Using the case of the UF/IFAS Extension Family Nutrition Program (FNP), this article illustrates steps ...
Glenn D. Israel, Halil I. Sari, Nicole Owens Duffy, Sebastian Galindo-Gonzalez, David C. Diehl, Saul J. Abarca Orozco, Elder Garcia Varela, Laura Sweeney   +7 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source