Results 51 to 60 of about 663,893 (316)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Online Learning, 2011 Adopting a new teaching approach is often a daunting task especially if one is an early adopter in a limited-resource environment. This article describes the challenges encountered and the strategies used in pilot testing a blended instructional method ...
Jane Kenney, Ellen Newcombe
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Educating 'Agents of Change' [PDF]
18th Conference on Software Engineering Education & Training (CSEET'05), 2005 This paper describes the journey undertaken by staff and students in an undergraduate SE program. It charts the progress to a learning environment that fosters reflective practice through a problem-based (cognitive) apprenticeship based on design studios.
openaire +1 more source
Research–Practice Partnership in a Professional Development Program: Promoting Youth at Risk
Education SciencesResearch–Practice Partnerships (RPPs) embody enduring collaborations between practitioners and researchers that systematically address practical challenges to enhance education.
Shirley Miedijensky, Irit Sasson
doaj +1 more source
IUL Research, 2022 The purpose of this reflection paper is to present a new framework to guide the process of investment in education infrastructure through participatory planning, and to consider its application to the development of innovative spaces.
Pamela Woolner, Yael Duthilleul
doaj +1 more source
A Training Program in Managing Educational Change [PDF]
, 1973 Supported by National Center for Improvement of Educational Systems, U.S. Office of Education. U.S. Office of Education Grant OEG-0-73-7075Division of Educational Administration. (1973). A Training Program in Managing Educational Change.
Division of Educational Administration
core
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Changing educational traditions with the change laboratory [PDF]
Education as Change, 2017 This paper outlines the use of a form of research intervention known as the Change Laboratory to illustrate how the processes of organisational change initiated at a secondary school can be applied to develop tools and practices to analyse and potentially re-make educational traditions in a bottom-up manner.
openaire +4 more sources