Results 71 to 80 of about 6,307,996 (298)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

A systematic review and meta-analysis of the association between sense of school belonging and externalizing behavior problems

Discover Psychology
The aim of the systematic review and meta-analysis was to investigate the association between school students’ sense of school belonging and externalizing behavior problems.
Naska Goagoses, Katharina Brosig, Ute von Düring, Jessica Wilke   +3 more
doaj   +1 more source

Framing heuristics in inclusive education: The case of Uganda’s preservice teacher education programme

African Journal of Disability, 2019
Background: Recent education-related research has raised concerns about the persistent exclusion of vulnerable learners in Uganda. The Revised Primary Teacher Education Curriculum of 2013 marked an ambitious yet inconclusive attempt to advance the ...
Proscovia S. Nantongo
doaj   +1 more source

A picture of special educational needs in England – an overview [PDF]

, 2019
This is the final version. Available on open access from Frontiers MediaData Availability: Publicly available datasets were analyzed in this study.
Black, AE
core   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Reducing anxiety symptoms in adolescents with pre-existing depression: results from a randomized control trial

Frontiers in Psychiatry
IntroductionDepression and anxiety have a long history of co-occurrence, with a relatively high prevalence in the Norwegian population both separate and combined.
Henriette Solberg, Thormod Idsoe, Serap Keles   +2 more
doaj   +1 more source

The Effectiveness of Dweck’s Mind Set Intervention on Students’ Negative Orientation Towards Problem and Hopelessness during the COVID-19 [PDF]

پژوهش‌های کاربردی روانشناختی
Aim: The aim of the present study was to investigate the Effectiveness of Dweck’s Mindset intervention on negative orientation towards problem and hopelessness in high school students.
Bahar Rashidi, Ahmad Abedi, Salar Faramarzi   +2 more
doaj   +1 more source