Results 71 to 80 of about 3,083,145 (314)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Frontiers in PsychiatryIntroductionDepression and anxiety have a long history of co-occurrence, with a relatively high prevalence in the Norwegian population both separate and combined.
Henriette Solberg +2 more
doaj +1 more source
The Effectiveness of Dweck’s Mind Set Intervention on Students’ Negative Orientation Towards Problem and Hopelessness during the COVID-19 [PDF]
پژوهشهای کاربردی روانشناختیAim: The aim of the present study was to investigate the Effectiveness of Dweck’s Mindset intervention on negative orientation towards problem and hopelessness in high school students.
Bahar Rashidi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Children and Young People Now, 2014 We describe the psychological content of the special educational needs of children with developmental disabilities in the conditions necessary for optimal realization of actual and potential child capacities (cognitive, energetic, emotional and volitional) in the learning process. We discuss the causes of the special needs that are specific patterns of
openaire +3 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Moral Self and Identity in Children, Adolescents, and Adults
Psychological Test Adaptation and Development: Research on morality, particularly on moral self and identity, is gaining increasing attention. However, the current literature reveals a lack of clarity in terminology, resulting in inconsistent operationalizations and instruments for studying moral ...
Neele Bäker, Jule Eilts, Jessica Wilke
doaj +1 more source
Segregation in an era of inclusion? The role of special classes in Irish mainstream schools. ESRI Research Bulletin, 2018/02 [PDF]
, 2018 This study assessed whether special classes operate as a form of segregation or inclusion for students with special educational needs. Ireland has a multi-track system of education where students with special educational needs can either attend ...
Banks, Joanne, McCoy, Selina
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source