Results 81 to 90 of about 6,307,996 (298)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The Need for Climate and Health Education
American Journal of Public Health, 2018 The article discusses the need for public information on climate change and health. Topics include the need for additional research on climate and health, the initiation of the Global Consortium on Climate and Health Education (GCCHE) by the Mailman School of Public Health at Columbia University, and an invitation for medical schools to join the GCCHE.
Jeffrey, Shaman, Kim, Knowlton
openaire +3 more sources
The educational needs of gifted children [PDF]
, 2001 This study assesses the extent to which the educational needs of a group of very able Year 10 students reflect the perceived educational needs of gifted children as drawn from a study of the literature.
Phillips, Eunice Dunbar
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Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Moral Self and Identity in Children, Adolescents, and Adults
Psychological Test Adaptation and Development: Research on morality, particularly on moral self and identity, is gaining increasing attention. However, the current literature reveals a lack of clarity in terminology, resulting in inconsistent operationalizations and instruments for studying moral ...
Neele Bäker, Jule Eilts, Jessica Wilke
doaj +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Frontiers in EducationThe participation of children with disabilities in early childhood education and care (ECEC) is not only a fundamental right, but also important for their development and well-being.
Janina Dott, Ulla Licandro
doaj +1 more source
Additional support needs and approaches to dispute resolution: the perspectives of Scottish parents [PDF]
, 2009 This paper draws on data from an ESRC funded project (RES-062-23-0803) which explores the use of dispute resolution mechanisms in the field of special educational needs in England and additional support needs in Scotland. Here, we present findings from a
Weedon, Elisabet, Riddell, Sheila
core