Results 71 to 80 of about 643,707 (311)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Obstacles to creating and finding Open Educational Resources: the case of research methods in the social sciences [PDF]

open access: yes, 2012
Social Research Methods are approaches to undertaking research shared not only by the social sciences, but by many other disciplines. There is therefore enormous scope for the creation and re-use of open educational resources (OERs) in this field ...
Gibbs, Graham R.   +6 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Scientific and educational partnerships to alleviate aquatic environmental problems in Eastern Europe : results of a workshop held at the Marine Sciences Research Center, April 22, 1992 [PDF]

open access: yes, 1992
51 leaves : ill. ; 28 cm. Includes bibliographical references.from the executive summary, ". . .Problems common to scientists in virtually all eastern European countries include lack of access to scientific information from other countries (and ...
Marine Sciences Research Center
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Investigation of higher education level social network analysis studies in educational sciences

open access: yesInternational Journal of Assessment Tools in Education
In this study, we conducted a holistic analysis of educational studies on social network analysis (SNA) in higher education. To this end, articles published in Web of Science between 2010 and 2020 on social network analysis at higher education level in ...
Akça Okan Yüksel, Sibel Somyürek
doaj   +1 more source

Prioritizing Science Education [PDF]

open access: yesScience, 2010
This special issue of Science explores “Grand Challenges in Science Education,” a critical set of the problems and exciting opportunities now facing science education on a global level. The 20 Challenges, addressed by a team of education experts, range from “Enable students to build on their own enduring, science ...
openaire   +4 more sources

Health sciences librarian as an adult trainer [PDF]

open access: yes, 2011
The role of the health sciences librarian as it is shaped by the socio-economic conditions, technological developments and specific information needs of health professionals requires knowledge, skills and attitudes combined with communication skills ...
Kalogeraki, Eleni, Tsalapatani, Eirini
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Les politiques d’égalité femmes/hommes en Suisse au prisme des carrières des docteur·e·s en sciences de l’éducation

open access: yesSociologies, 2019
While we can welcome the deployment by Swiss universities of "Equal Opportunities" action plans since the 2000s and observe the institutionalization of support mechanisms such as mentoring, we must also be concerned about the actual use of these ...
Geneviève Mottet
doaj  

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