Structural and biochemical insights into Zn2+-bound EF-hand proteins, EFhd1 and EFhd2 [PDF]
IUCrJ, 2023 EF-hand proteins, which contain a Ca2+-binding EF-hand motif, are involved in regulating diverse cellular functions. Ca2+ binding induces conformational changes that modulate the activities of EF-hand proteins.
Sang A Mun +6 more
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The Dually Localized EF-Hand Domain-Containing Protein TgEFP1 Regulates the Lytic Cycle of Toxoplasma gondii [PDF]
Cells, 2022 The propagation of the obligate intracellular parasite Toxoplasma gondii is tightly regulated by calcium signaling. However, the mechanisms by which calcium homeostasis and fluxes are regulated in this human pathogen are not fully understood. To identify
Noopur Dave +2 more
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EF-Hand Battle Royale: Hetero-ion Complexation in Lanmodulin [PDF]
JACS AuJeremy Seidel +4 more
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Two structural motifs within canonical EF-hand calcium-binding domains identify five different classes of calcium buffers and sensors. [PDF]
PLoS ONE, 2014 Proteins with EF-hand calcium-binding motifs are essential for many cellular processes, but are also associated with cancer, autism, cardiac arrhythmias, and Alzheimer's, skeletal muscle and neuronal diseases.
Konstantin Denessiouk +4 more
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In silico prediction and analysis of Caenorhabditis EF-hand containing proteins. [PDF]
PLoS ONE, 2012 Calcium (Ca⁺²) is a ubiquitous messenger in eukaryotes including Caenorhabditis. Ca⁺²-mediated signalling processes are usually carried out through well characterized proteins like calmodulin (CaM) and other Ca⁺² binding proteins (CaBP).
Manish Kumar +4 more
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Calcium affinity of human α-actinin 1 [PDF]
PeerJ, 2015 Due to alternative splicing, the human ACTN1 gene codes for three different transcripts of α-actinin; one isoform that is expressed only in the brain and two with a more general expression pattern.
Lars Backman
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The Interaction of Economic Freedom and Governance on Ecological Footprint (Selected Developing Countries) [PDF]
Pizhūhishnāmah-i Iqtiṣād-i Inirzhī-i Īrān, 2020 Environmental degradation is one of the most important concerns in developing countries. One of the most important indicators whose study helps to understand the extent of the world's support for improving the quality of the environment is the ecological
rezvan hemati +1 more
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Molecular dynamics of the neuronal EF-hand Ca2+-sensor Caldendrin. [PDF]
PLoS ONE, 2014 Caldendrin, L- and S-CaBP1 are CaM-like Ca2+-sensors with different N-termini that arise from alternative splicing of the Caldendrin/CaBP1 gene and that appear to play an important role in neuronal Ca2+-signaling. In this paper we show that Caldendrin is
Pasham Parameshwar Reddy +7 more
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The Highly Conservative Cysteine of Oncomodulin as a Feasible Redox Sensor
Biomolecules, 2021 Oncomodulin (Ocm), or parvalbumin β, is an 11–12 kDa Ca2+-binding protein found inside and outside of vertebrate cells, which regulates numerous processes via poorly understood mechanisms.
Alisa A. Vologzhannikova +6 more
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Fluorescence complementation via EF-hand interactions [PDF]
Journal of Biotechnology, 2009 Fluorescence complementation technology with fluorescent proteins is a powerful approach to investigate molecular recognition by monitoring fluorescence enhancement when non-fluorescent fragments of fluorescent proteins are fused with target proteins, resulting in a new fluorescent complex.
Ning, Chen +7 more
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