Results 91 to 100 of about 799,637 (297)

Kelvin-Helmholtz instability in an atomic superfluid

, 2018
We demonstrate an experimentally feasible method for generating the classical Kelvin-Helmholtz instability in a single component atomic Bose-Einstein condensate. By progressively reducing a potential barrier between two counter-flowing channels we seed a
Baggaley, A. W., Parker, N. G.
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

An effective theory of Feshbach resonances and many-body properties of Fermi gases

, 2004
For calculating low-energy properties of a dilute gas of atoms interacting via a Feshbach resonance, we develop an effective theory in which the parameters that enter are an atom-molecule coupling strength and the magnetic moment of the molecular ...
A. L. Fetter, C. J. Pethick, G. M. Bruun, V. M. Galitskii   +3 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Universality of the EMC Effect

, 2005
Using effective field theory, we investigate nuclear modification of nucleon parton distributions (for example, the EMC effect). We show that the universality of the shape distortion in nuclear parton distributions (the factorisation of the Bjorken x and
Arndt, Arneodo, Aubert, Beane, Beane, Beane, Bedaque, Belitsky, Chen, Chen, Chen, Chen, Chen, Cloet, Date, Detmold, Detmold, Detmold, Detmold, Detmold, Detmold, Diehl, Drakoulakos, Frankfurt, Geesaman, Gomez, Göckeler, Ji, Jiunn-Wei Chen, Kaplan, Kaplan, Kaplan, Kubodera, Kubodera, Luke, Lüscher, Meissner, Norton, Peng, Piller, Rinat, Saito, Smith, Smith, West, William Detmold   +45 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Effective Hamiltonian study of excitations in a boson- fermion mixture with attraction between components

, 2010
An effective Hamiltonian for the Bose subsystem in the mixture of ultracold atomic clouds of bosons and fermions with mutual attractive interaction is used for investigating collective excitation spectrum.
A M Belemuk, Abramowitz M, Chui S T, Lifshitz E M, Popov V N, Stoof H T C Kaiser R Westbrook C David F, V N Ryzhov   +6 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source