Results 101 to 110 of about 14,777,258 (301)

Centre for Effective Services: strategy 2012 – 2014 and beyond [PDF]

, 2012
The Centre for Effective Services (CES) was established in 2008 in the Republic of Ireland, and in 2010 in Northern Ireland. The overall remit of the centre was to provide technical and organisational ‘expertise’ to promote and support the application of
Centre for Effective Services
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Improving the Accuracy of the Effective Atomic Number (EAN) and Relative Electron Density (RED) with Stoichiometric Calibration on PCD-CT Images. [PDF]

Sensors (Basel), 2022
Son K, Kim D, Lee S.
europepmc   +1 more source

Nuclear Physics Section Progress Report

, 1955
Report discussing the progress of various projects at the Knolls Atomic Power Laboratory during the period from September to November ...
Knolls Atomic Power Laboratory
core  

Study of Rayleigh to Compton Scattering Ratio and Effective Atomic Number as a Function of Photon Energy and Scattering Angle

, 2019
For photon energies below 1 MeV the predominant phenomenon involved is photoelectric absorption, coherent scattering (Rayleigh), and incoherent scattering (Compton).
G. M. Pushpanjali, A. Manjunath, B. R. Kerur, Kerur, B. R.,, Pushpanjali, Gurubasappa Metri,, D. Mahalesh, Mahalesh, D.,, Balaji Biradar, Manjunath, A.,, Biradar, B.,   +9 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Quantitative parameters of carotid plaque based on dual-layer spectral-detector CT for stratifying cerebral small vessel disease

Frontiers in Neurology
ObjectiveCerebral small vessel disease (CSVD) is a major cause of vascular cognitive impairment and stroke, and has been linked to carotid atherosclerotic plaque characteristics.
Yuxin Ye, Yuxin Ye, Lin Lin, Yuxuan Liu, Yuxuan Liu, Chunmiao Lin, Yuyun Xu   +6 more
doaj   +1 more source

Image synthesis of effective atomic number images using a deep convolutional neural network-based generative adversarial network. [PDF]

Rep Pract Oncol Radiother, 2022
Kawahara D, Ozawa S, Saito A, Nagata Y.
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source