Results 111 to 120 of about 14,777,258 (301)

Comparative investigation of photon interaction parameters in psychoactive substances: the role of molecular composition

open access: yesResults in Physics
This study systematically evaluates the photon interaction characteristics of fifteen psychoactive substances over the energy range of 0.015–15 MeV using the EpiXS software package. Mass and linear attenuation coefficients (MAC and LAC), half-value layer
Fatma Akyıldız
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Physics Section Progress Report

open access: yes, 1955
Report discussing the progress of various projects at the Knolls Atomic Power Laboratory during the period from June to August ...
Knolls Atomic Power Laboratory
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Characterization of the rhizophora particleboard as a tissue-equivalent phantom material bonded with bio–based adhesive

open access: yesMaderas: Ciencia y Tecnología
In this study, some characteristics of Rhizophora spp. particleboards bonded with Serishoom (traditional animal–based adhesive) as a phantom material was investigated. The Rhizophora spp. particleboards were fabricated in two Serishoom adhesive treatment
Ehsan Taghizadeh Tousi   +8 more
doaj  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

The effective atomic number for gamma ray interactions with heavy metal oxide glasses

open access: yes, 2010
The effective atomic number, Z(eff), and the effective electron density, N-el,N-eff, have been calculated at photon energies from 1 keV to 100 GeV for CaO-SrO-B2O3, ZnO-PbO-B2O3, and CdO-PbO-B2O3 glasses with potential applications as gamma ray shielding
Hanagodimath, S.M.   +2 more
core  

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