Results 111 to 120 of about 181,833 (294)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

An alternative approach for determining the effective atomic number of some compounds: Monte Carlo study

Researchers have been searching for different methods to determine the effective atomic number of materials for many years. Therefore, there are many methods in the literature to determine the effective atomic number theoretically or experimentally ...
TOKER, ÖMER SAİD, İÇELLİ, ORHAN, KURUCU, Yakup, KALECİK, Sedanur, Ozsahin, M. T.   +4 more
core   +2 more sources

Clinical feasibility of using effective atomic number maps derived from non-contrast spectral computed tomography to identify non-calcified atherosclerotic plaques: a preliminary study. [PDF]

Quant Imaging Med Surg, 2022
Chen W, Li R, Yin K, Liang J, Li H, Chen X, Sheng Z, Yu H, Mu D.   +8 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Characterization of the rhizophora particleboard as a tissue-equivalent phantom material bonded with bio–based adhesive

Maderas: Ciencia y Tecnología
In this study, some characteristics of Rhizophora spp. particleboards bonded with Serishoom (traditional animal–based adhesive) as a phantom material was investigated. The Rhizophora spp. particleboards were fabricated in two Serishoom adhesive treatment
Ehsan Taghizadeh Tousi, Rokiah Hashim, Sabar Bauk, Mohamad Suhaimi Jaafar, Ali Mohammad Hamdan Abuarra, Amer Mahmoud Al-Jarrah, Baker Ababneh, Afsaneh Taghizadeh Tousi, Khalid Saleh Ali Aldroobi   +8 more
doaj  

Study of Rayleigh to Compton Scattering Ratio and Effective Atomic Number as a Function of Photon Energy and Scattering Angle

, 2019
For photon energies below 1 MeV the predominant phenomenon involved is photoelectric absorption, coherent scattering (Rayleigh), and incoherent scattering (Compton).
G. M. Pushpanjali, A. Manjunath, B. R. Kerur, Kerur, B. R.,, Pushpanjali, Gurubasappa Metri,, D. Mahalesh, Mahalesh, D.,, Balaji Biradar, Manjunath, A.,, Biradar, B.,   +9 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Single crystal x-ray diffraction studies on small, medium and large molecules [PDF]

, 1996
Chapter 1. Production of crystals for diffraction analysis would be assisted by the devising of a set of rules which, given molecular formula, could predict crystal formation conditions.
Butterworth, Susanna
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source