Results 111 to 120 of about 14,131,156 (297)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Atomic Energy Commission Report TID-7010

, 1957
Introduction: Atomic Energy Facts is designed to serve as an introduction to nuclear operations in the United States and as a handbook of related information for the use of industrial firms and other active or interested in atomic ...
U.S. Atomic Energy Commission
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Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Impact of MoO3 on gamma radiation shielding performance of B2O3–TeO2–GeO2–MgO glasses: experimental investigation

Discover Materials
This study presents data on the gamma radiation shielding properties of differential compositions of molybdenum oxide (MoO₃) incorporated into borate-tellurite-magnesium glasses with a formula of B2O3–TeO2–GeO2–MgO. The borate-tellurite-magnesium glasses
M.I. Sayyed, Mohamed Y. Hanfi, Berivan F. Namaq, Laith Ahmed Najam, Taha Yaseen Wais, Abed Jawad Kadhim, Kawa M. Kaky, Sudha D. Kamath   +7 more
doaj   +1 more source

The value of spectral CT quantitative parameters in predicting Ki-67 level in ovarian cancer

Frontiers in Oncology
ObjectiveThe objective of this study is to evaluate the predictive value of quantitative parameters from spectral CT for Ki-67 expression in ovarian cancer (OC).MethodsSpectral CT imaging data from 39 patients with ovarian cancer by pathology ...
Siwen Pang, Meng Wu, Haijia Yu, Tiantian Ma, Jianhua Liu, Siwen Liu   +5 more
doaj   +1 more source

Gulf General Atomic Company Report A12251

, 1973
Report discussing significant accomplishments during a four-month period regarding the development of a thermionic reactor for a nuclear space power system.
Gulf General Atomic Incorporated
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MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Dual-Layer Spectral Detector Computed Tomography Quantitative Parameters: A Potential Tool for Lymph Node Activity Determination in Lymphoma Patients

Diagnostics
Dual-energy CT has shown promising results in determining tumor characteristics and treatment effectiveness through spectral data by assessing normalized iodine concentration (nIC), normalized effective atomic number (nZeff), normalized electron density (
Hebing Chen, Yuxiang Fang, Jin Gu, Peng Sun, Lian Yang, Feng Pan, Hongying Wu, Tianhe Ye   +7 more
doaj   +1 more source

Report (U.S. Atomic Energy Commission) [PDF]

, 1963
Analysis of the stability of boiling water ...
U.S. Atomic Energy Commission
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