Results 101 to 110 of about 1,411,743 (333)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Causality and energy conditions in nonlinear electrodynamics

Journal of High Energy Physics
For the general theory of nonlinear electrodynamics (NLED) we prove that causality implies both the Dominant Energy Condition (DEC) and, surprisingly, the Strong Energy Condition (SEC).
Jorge G. Russo, Paul K. Townsend
doaj   +1 more source

Reductionism, Emergence, and Effective Field Theories [PDF]

, 2000
In recent years, a change in attitude in particle physics has led to our understanding current quantum field theories as effective field theories (EFTs).
Castellani, Elena
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Generalized T T ¯ $$ T\overline{T} $$ -like deformations in duality-invariant nonlinear electrodynamic theories

Journal of High Energy Physics
This study introduces a high-order perturbation methodology to categorize two primary solution types within duality-invariant nonlinear electrodynamic theories, adhering to the differential self-duality criterion.
H. Babaei-Aghbolagh, Song He, Hao Ouyang
doaj   +1 more source

Reparameterisation Invariance Constraints on Heavy Particle Effective Field Theories

, 1992
Since fields in the heavy quark effective theory are described by both a velocity and a residual momentum, there is redundancy in the theory: small shifts in velocity may be absorbed into a redefinition of the residual momentum.
Aneesh V. Manohar, Burdman, Carone, Cho, Cho, Dugan, Eichten, Eichten, Falk, Falk, Falk, Georgi, Georgi, Grinstein, Isgur, Isgur, Jenkins, Jenkins, Luke, Maiani, Michael Luke, Politzer, Politzer, Voloshin, Voloshin, Voloshin, Wise, Yan   +27 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Simplified self-dual electrodynamics

Journal of High Energy Physics
We present a new formulation of self-dual nonlinear electrodynamics in which interactions are determined by an auxiliary-field potential, with causality ensuring a unique solution to the auxiliary-field equation.
Jorge G. Russo, Paul K. Townsend
doaj   +1 more source

Chiral kinetic theory from effective field theory revisited

Journal of High Energy Physics, 2019
We revisit the chiral kinetic equation from high density effective theory approach, finding a chiral kinetic equation differs from counterpart derived from field theory in high order terms in the O(1/μ) expansion, but in agreement with the equation ...
Shu Lin, Aradhya Shukla
doaj   +1 more source

Effective field theories for topological insulators by functional bosonization

, 2013
Effective field theories that describes the dynamics of a conserved U(1) current in terms of "hydrodynamic" degrees of freedom of topological phases in condensed matter are discussed in general dimension $D=d+1$ using the functional bosonization ...
Chan, AtMa, Fradkin, Eduardo, Hughes, Taylor L., Ryu, Shinsei   +3 more
core   +1 more source