Results 241 to 250 of about 3,891,523 (334)

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

PSMCanalysis of effective population sizes in molecular ecology and its application to black‐and‐whiteFicedulaflycatchers [PDF]

, 2016
Krystyna Nadachowska‐Brzyska, Reto Burri, Linnéa Smeds, Hans Ellegren   +3 more
openalex   +1 more source

A reduction in effective population size has not relaxed purifying selection in the human population of Eivissa (Balearic Islands). [PDF]

Sci Rep
Aizpurua-Iraola J, Marí-Cardona E, Barber-Olives M, Comas D, Calafell F.   +4 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Comparative Demographic History Analysis and PSMC Effective Population Size Estimates for Bobwhite (<i>Colinus virginianus</i>) (A) and Scarlet Macaw (<i>Ara macao</i>) (B).

, 2015
Yvette A. Halley (534280), Dowd Scot E., Jared E. Decker (534281), Paul M. Seabury (194366), Bhattarai Eric, Charles D. Johnson (534283), Dale Rollins, Ian R. Tizard (411122), Donald J. Brightsmith (411118), Markus J. Peterson (534285), Jeremy F. Taylor (179789), Christopher M. Seabury (194409)   +11 more
openalex   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

What does effective population size tell us about loss of allelic variation? [PDF]

Evol Appl
Allendorf FW, Hössjer O, Ryman N.
europepmc   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Inferring Effective Population Size and Divergence Time in the Lithuanian Population According to High-Density Genotyping Data

, 2020
Alina Urnikytė, Alma Molytė, Erinija Pranckevičienė, Zita Aušrelė Kučinskienė, Vaidutis Kučinskas   +4 more
openalex   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source