Results 221 to 230 of about 3,891,523 (334)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Accurate Non-parametric Estimation of Recent Effective Population Size from Segments of Identity by Descent [PDF]

, 2015
Sharon R. Browning, Brian L. Browning
openalex   +1 more source

Effective population size does not explain long-term variation in genome size and transposable element content in animals. [PDF]

Elife
Marino A, Debaecker G, Fiston-Lavier AS, Haudry A, Nabholz B.   +4 more
europepmc   +1 more source

Genetic diversity, structure, and effective population size of an endangered, endemic hoary bat, 'ōpe'ape'a, across the Hawaiian Islands. [PDF]

PeerJ, 2023
Pinzari CA, Bellinger MR, Price D, Bonaccorso FJ.   +3 more
europepmc   +1 more source

An Additional Report on the Estimation of the Effective Population Size for Changes in the Number of Individuals Between the Parental and the Progeny Populations.

, 1958
Ken NOZAWA
openalex   +2 more sources

Population Genetic Structure, Historical Effective Population Size, and Dairy Trait Selection Signatures in Chinese Red Steppe and Holstein Cattle. [PDF]

Animals (Basel)
Niu P, Li X, Wang X, Qu H, Chen H, Huang F, Hu K, Fang D, Gao Q.   +8 more
europepmc   +1 more source

Estimation of Linkage Disequilibrium, Effective Population Size, and Genetic Parameters of Phenotypic Traits in Dabieshan Cattle. [PDF]

Genes (Basel), 2022
Jin H, Zhao S, Jia Y, Xu L.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Estimating effective population size trajectories from time-series identity-by-descent segments. [PDF]

Genetics
Huang Y, Carmi S, Ringbauer H.
europepmc   +1 more source

Inferring Long-Term Effective Population Size with Mutation-Selection Models. [PDF]

Mol Biol Evol, 2021
Latrille T, Lanore V, Lartillot N.
europepmc   +1 more source