Results 221 to 230 of about 1,499,816 (300)

Reconstructing the History of Variation in Effective Population Size along Phylogenies. [PDF]

Genome Biol Evol, 2021
Brevet M, Lartillot N.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Spatial and temporal dynamics of the male effective population size in bumblebees (Hymenoptera: Apidae)

, 2011
Theresa Toev, Stephan Wolf, Robin F. A. Moritz, Moritz, R. F. A., Ruby L. V. Moritz, Wolf, S., Toev, T., Moritz, R. L. V.   +7 more
core   +1 more source

Effective Population Size Estimation in Large Marine Populations: Considering Current Challenges and Opportunities When Simulating Large Data Sets With High-Density Genomic Information. [PDF]

Evol Appl
Delord C, Arnaud-Haond S, Leone A, Noskova E, Tournebize R, Jacques P, Marsac F, Nikolic N.   +7 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Does Effective Population Size Govern Evolutionary Differences in Telomere Length? [PDF]

Genome Biol Evol
Brown LM, Elbon MC, Bharadwaj A, Damle G, Lachance J.   +4 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A reduction in effective population size has not relaxed purifying selection in the human population of Eivissa (Balearic Islands). [PDF]

Sci Rep
Aizpurua-Iraola J, Marí-Cardona E, Barber-Olives M, Comas D, Calafell F.   +4 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

What does effective population size tell us about loss of allelic variation? [PDF]

Evol Appl
Allendorf FW, Hössjer O, Ryman N.
europepmc   +1 more source