Results 131 to 140 of about 16,803 (230)

Efferocytosis: the art of cellular clearance and novel perspectives in disease therapy

Molecular Cancer
Efferocytosis, the process of apoptotic cell clearance, is a fundamental biological mechanism for maintaining tissue homeostasis. However, its role in disease pathogenesis is often oversimplified, neglecting a critical knowledge gap: how the single ...
Gege Li, Jiashuai Xu, Xiaohan Tian, Jingyi Xiao, Junqi Long, Yining Chen, Wenzhi Shen, Shuangtao Zhao   +7 more
doaj   +1 more source

Consequence of alcohol intoxication-mediated efferocytosis impairment

Frontiers in Immunology
Alcohol ingestion is a widespread habituation that evolved along with a growing population, altering physiological conditions through immunomodulatory function.
Subhashini Brahadeeswaran, Ramasamy Tamizhselvi   +1 more
doaj   +1 more source

Broad-spectrum antibiotics disrupt homeostatic efferocytosis

Nature Metabolism
The clearance of apoptotic cells, termed efferocytosis, is essential for tissue homeostasis and prevention of autoimmunity1. Although past studies have elucidated local molecular signals that regulate homeostatic efferocytosis in a tissue2,3, whether signals arising distally also regulate homeostatic efferocytosis remains elusive.
Pedro H. V. Saavedra, Alissa J. Trzeciak, Allie Lipshutz, Andrew W. Daman, Anya J. O’Neal, Zong-Lin Liu, Zhaoquan Wang, Jesús E. Romero-Pichardo, Waleska Saitz Rojas, Giulia Zago, Marcel R. M. van den Brink, Steven Z. Josefowicz, Christopher D. Lucas, Christopher J. Anderson, Alexander Y. Rudensky, Justin S. A. Perry   +15 more
openaire   +2 more sources

The efferocytosis dilemma: how neutrophil extracellular traps and PI3K/Rac1 complicate diabetic wound healing

Cell Communication and Signaling
Aims/hypothesis The resolution of apoptotic cells (ACs) is crucial for wound healing and tissue remodeling and is often impaired by persistent inflammation.
Yulin Xie, Jiaman Yang, He Zhu, Rongya Yang, Yunlong Fan   +4 more
doaj   +1 more source

The intricate interplay between ferroptosis and efferocytosis in cancer: unraveling novel insights and therapeutic opportunities

Frontiers in Oncology
The complex interplay between ferroptosis and efferocytosis in cancer has attracted significant interest recently. Efferocytosis, the process of eliminating apoptotic cells, is essential for preserving tissue homeostasis and reducing inflammation ...
Ali Ahmadizad Firouzjaei, Samira Mohammadi-Yeganeh   +1 more
doaj   +1 more source

Activated protein C ameliorates diabetes-induced atherosclerosis by sustaining macrophage efferocytosis

Cardiovascular Diabetology
Macrophage efferocytosis, essential for the resolution of inflammation and plaque stability in atherosclerosis, is impaired in diabetes. Thrombomodulin (TM) and endothelial protein C receptor (EPCR), key mediators of protein C activation (PC), have ...
Saira Ambreen, Amna Arif, Saikal Shamkeeva, Ahmed Elwakiel, Surinder Pal, Shihai Jiang, Muhammad Asad Farhan, Zuhir Halloul, John H. Griffin, Berend Isermann, Khurrum Shahzad   +10 more
doaj   +1 more source

Immunomodulation of wound healing leading to efferocytosis

Smart Medicine
AbstractEffectively eliminating apoptotic cells is precisely controlled by a variety of signaling molecules and a phagocytic effect known as efferocytosis. Abnormalities in efferocytosis may bring about the development of chronic conditions, including angiocardiopathy, chronic inflammatory diseases and autoimmune diseases. During wound healing, failure
Yun Zhao, Minxiong Li, Jiayi Mao, Yinghong Su, Xin Huang, Wenzheng Xia, Xiangfeng Leng, Tao Zan   +7 more
openaire   +3 more sources

IRG1/itaconate enhances efferocytosis by activating Nrf2-TIM4 signaling pathway to alleviate con A induced autoimmune liver injury

Cell Communication and Signaling
Immune response gene 1 (IRG1) is highly expressed in mitochondria of macrophages in a pro-inflammatory state. IRG1 and its metabolites play important roles in infection, immune-related diseases and tumor progression by exerting resistance of pathogens ...
Liwu Zeng, Yaxin Wang, Yongzhou Huang, Wenchang Yang, Pei Zhou, Yaqi Wan, Kaixiong Tao, Ruidong Li   +7 more
doaj   +1 more source

Transglutaminase 2 function in glioblastoma tumor efferocytosis

Cell Death and Disease
Glioblastoma is an aggressive and incurable type of brain cancer. Regions of tissue necrosis are a distinctive pathological feature of this cancer. These arise through thrombosis of tumor vasculature, driven by tumor-derived pro-coagulation factors.
Margarita Lui, Filiz Sevinc, Mara Elgafarawi, David G. Munoz, Jeffrey W. Keillor, John Sinclair, Dragosh Catana, Meshari Alhuthayl, John Woulfe, Ian AJ Lorimer   +9 more
doaj   +1 more source

Macrophage Efferocytosis in Heart. [PDF]

Arterioscler Thromb Vasc Biol
Inui H, Yu X, Pfrender E, Bednarek J, Zhang L, Thorp EB.   +5 more
europepmc   +1 more source