Results 191 to 200 of about 16,803 (230)

Macrophage efferocytosis in atherosclerosis

Scandinavian Journal of Immunology, 2023
AbstractThis paper presents the role of macrophage efferocytosis, the process of elimination of apoptotic bodies—elements formed during vascular atherosclerosis. The mechanisms of macrophage efferocytosis are presented, introducing the specific signals of this process, that is, ‘find me’, ‘eat me’ and ‘don't eat me’.
Łukasz Baraniecki, Beata Tokarz‐Deptuła, Anhelli Syrenicz, Wiesław Deptuła   +3 more
openaire   +2 more sources

Efferocytosis in health and disease

Nature Reviews Immunology, 2019
The clearance of apoptotic cells by professional and non-professional phagocytes - a process termed 'efferocytosis' - is essential for the maintenance of tissue homeostasis. Accordingly, defective efferocytosis underlies a growing list of chronic inflammatory diseases. Although much has been learnt about the mechanisms of apoptotic cell recognition and
Amanda C Doran, Arif Yurdagul, Ira A Tabas   +2 more
exaly   +4 more sources

Efferocytosis in atherosclerosis

Nature Reviews Cardiology
Cardiovascular disease is the leading cause of death worldwide, and it commonly results from atherosclerotic plaque progression. One of the increasingly recognized drivers of atherosclerosis is dysfunctional efferocytosis, a homeostatic mechanism responsible for the clearance of dead cells and the resolution of inflammation.
Nicholas J Leeper
exaly   +3 more sources

Interplay between efferocytosis and atherosclerosis

Archives of Cardiovascular Diseases, 2023
In an adult human, billions of cells die and turn over daily. During this process, many apoptotic cells are produced and subsequently cleared by phagocytes - a process termed efferocytosis, which plays a critical role in tissue homeostasis. Efferocytosis is an important mechanism in the control of inflammatory processes.
Luc, Rochette, Geoffrey, Dogon, Eve, Rigal, Marianne, Zeller, Yves, Cottin, Catherine, Vergely   +5 more
openaire   +2 more sources

Methods for Quantitative Efferocytosis Assays

2023
Efferocytosis, the phagocytic removal of apoptotic cells, is a dynamic process requiring recruitment of numerous regulatory proteins to mediate the uptake, engulfment, and degradation of apoptotic cells. Herein, we describe microscopy-based methods for the enumeration of efferocytic events and characterization of the spatiotemporal dynamics of ...
Nima, Taefehshokr, Bryan, Heit
openaire   +2 more sources

Quantitative Efferocytosis Assays

2016
Efferocytosis, the phagocytic removal of apoptotic cells, is a dynamic process requiring recruitment of numerous regulatory proteins to forming efferosomes in a tightly regulated manner. Herein we describe microscopy-based methods for the enumeration of efferocytic events and characterization of the spatiotemporal dynamics of signaling molecule ...
Amanda L, Evans, Jack W D, Blackburn, Charles, Yin, Bryan, Heit   +3 more
openaire   +2 more sources

Effect of diabetes on efferocytosis process

Molecular Biology Reports, 2022
Diabetes is a complex of genetic, metabolic, and autoimmune disorders that are characterized by hyperglycemia. Elevated apoptotic cell count following defective clearance of dead cells that can cause chronic inflammation is a hallmark of the diabetic wound. Effective dead cell clearance is a prerequisite for rapid inflammation resolution and successful
Ali Mahmoudi, Ali Ahmadizad firouzjaei, Fatemeh darijani, Jamshid Gholizadeh Navashenaq, Eskandar Taghizadeh, Majid Darroudi, Seyed Mohammad Gheibihayat   +6 more
openaire   +2 more sources

The Role of Efferocytosis in Atherosclerosis [PDF]

Circulation, 2017
The necrotic core has long been a hallmark of the vulnerable atherosclerotic plaque. Although apoptotic cells are cleared quickly in almost all other tissue beds, their removal appears to be significantly impaired in the diseased blood vessel. Emerging evidence indicates that this phenomenon is caused by a defect in efferocytosis, the process by which ...
Irving L Weissman, Nicholas J Leeper
exaly   +3 more sources

Cell Removal: Efferocytosis

Annual Review of Cell and Developmental Biology, 2017
In metazoans, removal of cells in situ is involved in larval maturation, metamorphosis, and embryonic development. In adults, such cell removal plays a role in the homeostatic maintenance of cell numbers and tissue integrity as well as in the response to cell injury and damage.
openaire   +2 more sources

Efferocytosis and Bone Dynamics

Current Osteoporosis Reports
This review summarizes the recently published scientific evidence regarding the role of efferocytosis in bone dynamics and skeletal health.Several types of efferocytes have been identified within the skeleton, with macrophages being the most extensively studied. Efferocytosis is not merely a 'clean-up' process vital for maintaining skeletal homeostasis;
Lena, Batoon, John R, Hawse, Laurie K, McCauley, Megan M, Weivoda, Hernan, Roca   +4 more
openaire   +2 more sources