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mBio, 2020 This research analyzed six Aspergillus fumigatus genes encoding putative efflux proteins for their roles as transporters. The A. fumigatus genes abcA, abcC, abcF, abcG, abcH, and abcI were cloned into plasmids and overexpressed in a Saccharomyces ...
Brooke D. Esquivel +5 more
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Frontiers in Microbiology, 2022 Quaternary ammonium compounds (QACs) are widely used as active agents in disinfectants, antiseptics, and preservatives. Despite being in use since the 1940s, there remain multiple open questions regarding their detailed mode-of-action and the mechanisms,
Niclas Nordholt +6 more
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Cholesterol Efflux Assay [PDF]
Journal of Visualized Experiments, 2012 Cholesterol content of cells must be maintained within the very tight limits, too much or too little cholesterol in a cell results in disruption of cellular membranes, apoptosis and necrosis. Cells can source cholesterol from intracellular synthesis and from plasma lipoproteins, both sources are sufficient to fully satisfy cells' requirements for ...
Hann, Low, Anh, Hoang, Dmitri, Sviridov
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Targeted cholesterol efflux [PDF]
Cell Cycle, 2013 In the process of reverse cholesterol transport, high-density lipoprotein (HDL) transports excess cholesterol from peripheral cells back to the liver, where cholesterol is recycled or metabolized and excreted. On the cellular level, 2 membrane-associated ATP-binding cassette (ABC) cholesterol transporters, ABCA1 and ABCG1, play a major role in ...
Fang, Longhou, Miller, Yury I
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Role of Efflux Pump Gene adeIJK to Multidrug Resistance in Acinetobacter baumanniiClinical Isolates
Annals of Clinical Microbiology, 2020 The emergence of multidrug-resistant Acinetobacter baumanniias a nosocomial pathogen is one of the major public health problems. The aim of this study was to evaluate the role of an efflux pump gene adeJ for the multidrug resistance of A ...
Ji Ae Choi +7 more
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Consideration of Metabolite Efflux in Radiolabelled Choline Kinetics
Pharmaceutics, 2021 Hypoxia is a complex microenvironmental condition known to regulate choline kinase α (CHKA) activity and choline transport through transcription factor hypoxia-inducible factor-1α (HIF-1α) and, therefore, may confound the uptake of choline radiotracer ...
Yunqing Li +14 more
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Frontiers in Microbiology, 2018 The Burkholderia cenocepacia epidemic ET12 lineage belongs to the genomovar IIIA including the reference strain J2315, a highly transmissible epidemic B. cenocepacia lineage.
Josselin Bodilis +6 more
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Antibiotics, 2019 We previously showed that berberine attenuates MexXY efflux-dependent aminoglycoside resistance in Pseudomonas aeruginosa. Here, we aimed to synthesize berberine derivatives with higher MexXY inhibitory activities. We synthesized 11 berberine derivatives,
Kenta Kotani +7 more
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Hydraulics are a first order control on CO2 efflux from fluvial systems [PDF]
, 2015 Evasion of carbon dioxide (CO2) from fluvial systems is now recognized as a significant component of the global carbon cycle. However the magnitude of, and controls on, this flux remain uncertain and improved understanding of both are required to refine ...
Hoey, Trevor +5 more
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Cell cholesterol efflux: integration of old and new observations provides new insights
Journal of Lipid Research, 1999 Numerous studies using a variety of cell/acceptor combinations have demonstrated differences in cholesterol efflux among cells. These studies also show that different acceptors, ranging from simple molecules like cyclodextrins to serum, stimulate efflux ...
George H. Rothblat +5 more
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