Results 91 to 100 of about 122,546 (256)

The Inhibitory Effect of Artemisa quttensis Extract on norA Efflux Pump in Ciprofloxacin Resistant Staphylococcus aureus Strains Using Ethidium Bromide and Real-Time PCR Methods

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2017
Background and Objectives: norA efflux pump is one of the mechanisms of ciprofloxacin resistance in Staphylococcus aureus strains, and finding natural herbal compounds with the ability to inhibit efflux pumps is one of the recent challenges.
Amir Mirzaie, Ali Asghar Bagheri Kashtali, Hassan Noorbazargan, Seyed Ataollah Sadat Shandiz   +3 more
doaj  

Virtual screening and biological activity evaluation of novel efflux pump inhibitors targeting RE-CmeB in Campylobacter spp.

One Health Advances
RE-CmeABC is a variant of the efflux pump CmeABC in the major zoonotic pathogen Campylobacter, which is much more potent in conferring resistance to various antibiotics for the treatment of Campylobacter infections in both veterinary and medical clinics.
Shihong Li, Cheng Zhang, Wenjun Li, Shuigen Wan, Jin Kang, Yong Liu, Hexiang Huang, Hao Li, Longhua Yang, Yanhong Shang, Chenglong Li, Xiangdang Du, Hong Yao   +12 more
doaj   +1 more source

A Molecular Modeling Approach to Identify Novel Inhibitors of the Major Facilitator Superfamily of Efflux Pump Transporters

Antibiotics, 2019
Multidrug efflux systems play a prominent role in medicine, as they are important contributors to bacterial antibiotic resistance. NorA is an efflux pump transporter from the major facilitator superfamily that expels numerous drug compounds across the ...
Sandra G. Zárate, Paula Morales, Katarzyna Świderek, Victor M. Bolanos-Garcia, Agatha Bastida   +4 more
doaj   +1 more source

Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions [PDF]

, 2014
Antimicrobials targeting cell wall biosynthesis are generally considered inactive against nonreplicating bacteria. Paradoxically, we found that under nonpermissive growth conditions, exposure of Mycobacterium bovis BCG bacilli to such antimicrobials ...
Andrew, Peter W, Burke, Bernard, Butcher, Philip D, Cohen-Gonsaud, Martin, Glenn, Sarah, Labesse, Gilles, Mukamolova, Galina V, Sarybaeva, Asel A, Tudo, Griselda, Turapov, Obolbek, Waddell, Simon J, Young, Danielle I, Young, Michael   +12 more
core   +2 more sources

Efflux Pumps and These Inhibitors

VNU Journal of Science: Medical and Pharmaceutical Sciences, 2019
 In this era of multi-drug resistance, efflux pump is one of the major problems which is increasingly concerned by scientists. The structure and mechanism activity of the efflux pumps on both bacteria and eurakyotes that are gradually being clarified. Since then, efflux pump inhibitors have also been studied and initially applied in clinic, that makes ...
Le Minh Tri, Nguyen Hoang Minh, Hoang Tung, Do Tran Giang Son, Phan Thien Vy, Tran Thanh Dao, Thai Khac Minh   +6 more
openaire   +2 more sources

The effect of carbonyl cyanide m-chlorophenyl-hydrazine on antibiotic susceptibility in MDR Enterobacteriaceae isolates in Babylon, Iraq

Medical Journal of Babylon
Background: One of the efflux pump inhibitors is carbonyl cyanide 3-chlorophenylhydrazone (CCCP) that has often been found to increase the susceptibility of a number of multi-drug resistant (MDR) MDR bacteria, isolated from human clinical specimens ...
Hadeel Qasim Jebur, Alaa H. Al-Charrakh
doaj   +1 more source

Adjuvant Activity and Resistance-Modifying Capacity of a Novel Heterocyclic Hydrazone Derived from the Drug Hydralazine in NorA and MepA Efflux Pumps of Staphylococcus aureus

Drugs and Drug Candidates
Background/Objectives: Hydrazones are organic compounds with the general structure R2C=NNHR1, distinguished by their versatility and modifiability, and are widely used in various applications due to their physicochemical and biological properties.
Milena Oliveira Andrade Moreira, Karla Susanna Tavares Grangeiro Belém, Janaina Esmeraldo Rocha, Davi Ramalho Furtado, Gildenia Alves de Araújo, Ana Joyce Morais Bento, Jessica Bezerra Maciel, Jesyka Macêdo Guedes, Jaiza Maria Lima Dias, Henrique Douglas Melo Coutinho, Francisco das Chagas Lima Pinto, Emmanuel Silva Marinho, Marcia Machado Marinho, Alexandre Magno Rodrigues Teixeira, Walter José Peláez, Hélcio S. dos Santos   +15 more
doaj   +1 more source

Transcriptome assembly and profiling of Candida auris reveals novel insights into biofilm-mediated resistance [PDF]

, 2018
Candida auris has emerged as a significant global nosocomial pathogen. This is primarily due to its antifungal resistance profile but also its capacity to form adherent biofilm communities on a range of clinically important substrates.
Ben-Ami, Berkow, Berkow, Bizerra, Bongomin, Borman, Borman, Calvo, Chatterjee, Chowdhary, Defosse, Denning, Dominguez, Fisher, Fonseca, Fox, Fu, Grahl, Haas, Hager, Hashemi, Hunter, Jeffery-Smith, Kean, Kean, Kean, Kean, Kempf, Kordalewska, Kordalewska, Larkin, Liu, Liu, Lockhart, Lohse, Martínez, Mukherjee, Naglik, Naglik, Nailis, Nobile, Perfect, Pierce, Rajendran, Rajendran, Rajendran, Ramage, Ramage, Ramage, Rodrigues, Ruiz-Gaitán, Schelenz, Sherry, Sherry, Silva, Soldini, Taff, Taff, Tumbarello, Tunney, Winter, Zarnowski, Zhao, Zhao   +63 more
core   +4 more sources

Bacterial Resistance Toward Antimicrobial Ionic Liquids Mediated by Multidrug Efflux Pumps [PDF]

, 2022
Tobias Gundolf, Roland Kalb, Peter Rossmanith, Patrick Mester   +3 more
openalex   +1 more source

Molecular similarity of MDR inhibitors [PDF]

, 2004
Everyone is free to re-use the published material if proper accreditation/citation of the original publication is given. http://creativecommons.org/licences/by/3.0/The molecular similarity of multidrug resistance (MDR) inhibitors was evaluated using the ...
Gibbons, S., Zloh, Mire
core   +2 more sources