Results 181 to 190 of about 71,112 (299)

Essential embryology for the Canadian pathologists’ assistant

Anatomical Sciences Education, EarlyView.
Abstract Pathologists' assistants (PAs) are pivotal in healthcare, conducting autopsies and examining tissues under a pathologist's guidance. Embryology knowledge is crucial for PAs to accurately assess anomalies and identify pathologies. Yet, it is often overlooked in academic PA training programs.
Samantha H. Nacci, William Tsui, Fang‐I Lu, Avrum I. Gotlieb, Danielle C. Bentley   +4 more
wiley   +1 more source

Overcoming Multidrug Resistance by Bacterial Efflux Pump Inhibitors in Clinical <i>Escherichia coli</i> Strains. [PDF]

Antibiotics (Basel)
Szemerédi N, Nové M, Heo D, Orosz L, Sóki J, Spengler G.   +5 more
europepmc   +1 more source

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

Integrons and Efflux Pump-Mediated Antibiotic Resistance in Multidrug-Resistant (MDR) Uropathogenic Escherichia coli. [PDF]

Biomed Res Int
Gonbadi MA, Dini Y, Mohammadi M, Pournajaf A, Halaji M.   +4 more
europepmc   +1 more source

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source

Computational discovery of new efflux pump inhibitors that target AcrA of the Escherichia coli AcrAB-TolC efflux pump

, 2019
Antibiotics are compounds that kill or slow the growth of bacteria to treat numerous bacterial infections. No new class of antibiotic has been identified in the past thirty years despite the increased use of current antibiotics around the world.
Green, Adam
core  

Berberine hydrochloride combination therapy and efflux pump regulation mechanism ameliorates antimicrobial resistance of <i>Acinetobacter baumannii</i>. [PDF]

Microbiol Spectr
Wang J, Kuang Y, Zou H, Peng C, Zhou Y, Zhang X, Hu Z, Chen S, Feng L.   +8 more
europepmc   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Substrate Specificity Checkpoints of the Multidrug Efflux Pump MexF from <i>Pseudomonas aeruginosa</i>. [PDF]

ACS Infect Dis
Uddin MR, Gervasoni S, Malloci G, Ruggerone P, Zgurskaya HI.   +4 more
europepmc   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source