Results 171 to 180 of about 119,180 (205)

Inhibition of the multidrug resistance efflux pump

Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1993
An ATP-dependent efflux pump is found in the plasma membrane of certain multidrug resistant (MDR) cancer cells. Drug resistance is due to decreased intracellular drug levels that have been reduced to subcytotoxic concentrations. Inhibition of the MDR efflux pump with a reversal agent may 'trap' the cytotoxic drug inside the cell; thus, cellular drug ...
P W, Wigler, F K, Patterson
openaire   +2 more sources

Determination of the Efflux Pump-Mediated Resistance Prevalence in Pseudomonas aeruginosa, Using an Efflux Pump Inhibitor

Current Microbiology, 2009
In gram negative bacteria, fluoroquinolone resistance is acquired by target mutations in topoisomerase genes or by reducing the permeation of drugs due to the increase in expression of endogenous multidrug efflux pumps that expel structurally unrelated antimicrobial agents.
Abolghasem, Tohidpour, Shahin, Najar Peerayeh, Jalil F, Mehrabadi, Hadi, Rezaei Yazdi   +3 more
openaire   +2 more sources

Cholestasis and the Role of Basolateral Efflux Pumps

Zeitschrift für Gastroenterologie, 2011
ATP-dependent transport of biliary constituents, such as bile acids, reduced glutathione, and bilirubin glucuronosides across the hepatocyte canalicular membrane into bile represents the decisive driving force for the formation of biliary fluid. Functional characterization, cloning, and localization of hepatocellular transporter proteins has provided a
openaire   +2 more sources

Efflux pump activity in Enchytraeidae

2019
Enchytraeids are ecologically relevant soil organisms, which play an important role in organic matter decomposition and soil bioturbation. They live in close contact with the pore water fraction of soil which makes them vulnerable to xenobiotics exposure.
Hackenberger Kutuzović, Davorka, Lončarić, Željka, Hackenberger Kutuzović, Branimir, Kovačević, Marija   +3 more
openaire   +1 more source

Inhibitors of Efflux Pumps

Multidrug-resistant bacteria are a major public health threat. MDR efflux pump overexpression and enzymatic changes are major antibiotic resistance mechanisms. Many drug and biofilm resistance strategies involve efflux pumps. Natural substrate and inhibitor identification is a new study. Efflux pump inhibition allows medication buildup inside bacterial
Neeraj Kumar, Sudeshna Bhattacharjee, Rama Tyagi   +2 more
openaire   +1 more source

Efflux pump inhibitors in bacteria

Expert Opinion on Therapeutic Patents, 2007
The efficacy of antibiotherapy of infectious diseases is strongly compromised by the advent and spread of antibiotic resistance. Active efflux of cytotoxic drugs mediated by multi-drug transporters is the basis of multi-drug resistance in prokaryotic cells.
Sandrine Alibert, Jean-Marie Pagès
openaire   +1 more source

Microbial Efflux of Antibiotics and Inhibitors of Efflux Pumps

2014
Detergent-like bile salts kill bacterial cells by destroying bacterial multidrug resistance (MDR) efflux systems. These not only play an important role in antibacterial resistance but also contribute to bacterial pathogenesis. Reserpine and H+/K+ ATPase inhibitors can significantly reduce MICs, increase killing activity, and prolong the postantibiotic ...
openaire   +1 more source

The RND Efflux Pump Gene Expression in the Biofilm Formation of Acinetobacter baumannii

Antibiotics, 2023
Ola A Abd El-Rahman, Fatma Rasslan, Safaa S Hassan   +2 more
exaly  

The role and relationship with efflux pump of biofilm formation in Klebsiella pneumoniae

Microbial Pathogenesis, 2020
Xing Wei, Jinbo Liu
exaly  

Efflux Pumps

RCSB Protein Data Bank
Steven Arnold, Shuchismita Dutta
openaire   +1 more source