Results 31 to 40 of about 122,546 (256)
Journal of Infection in Developing Countries, 2023 Introduction: Enterococcus faecium is a major cause of community and hospital-acquired infections. Due to limited options for infection with fluoroquinolones-resistant Enterococci, novel therapeutics are urgently needed.
Mehdi Mirzaii +7 more
doaj +1 more source
Drug absorption through a cell monolayer: a theoretical work on a non-linear three-compartment model [PDF]
, 2009 The subject of analysis is a non-linear three-compartment model, widely used in pharmacological absorption studies. It has been transformed into a general form, thus leading automatically to an appropriate approximation.
Acharya +31 more
core +2 more sources
Mechanisms of RND multidrug efflux pumps [PDF]
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2009 RND (Resistance-Nodulation-Division) family transporters are widespread especially among Gram-negative bacteria, and catalyze the active efflux of many antibiotics and chemotherapeutic agents. They have very large periplasmic domains, and form tripartite complexes with outer membrane channels and periplasmic adaptor proteins.
Hiroshi, Nikaido, Yumiko, Takatsuka
openaire +2 more sources
Efflux pumps and microbial biofilm formation
Infection, Genetics and Evolution, 2023 Biofilm-related infections are resistant forms of pathogens that are regarded as a medical problem, particularly due to the spread of multiple drug resistance. One of the factors associated with biofilm drug resistance is the presence of various types of efflux pumps in bacteria.
Mahdyeh Neghabi, Hajiagha +1 more
openaire +2 more sources
A mass spectrometry-based assay for improved quantitative measurements of efflux pump inhibition.
PLoS ONE, 2015 Bacterial efflux pumps are active transport proteins responsible for resistance to selected biocides and antibiotics. It has been shown that production of efflux pumps is up-regulated in a number of highly pathogenic bacteria, including methicillin ...
Adam R Brown +9 more
doaj +1 more source
Antisense PNA accumulates in Escherichia coli and mediates a long post-antibiotic effect [PDF]
, 2007 Antisense agents that target growth-essential genes display surprisingly potent bactericidal properties. In particular, peptide nucleic acid (PNA) and phosphorodiamidate morpholino oligomers linked to cationic carrier peptides are effective in time kill ...
Behmanesh, Mehrdad +9 more
core +2 more sources
Efflux pump proteins in antifungal resistance [PDF]
Frontiers in Pharmacology, 2014 It is now well-known that the enhanced expression of ATP binding cassette (ABC) and major facilitator superfamily (MFS) proteins contribute to the development of tolerance to antifungals in yeasts. For example, the azole resistant clinical isolates of the opportunistic human fungal pathogen Candida albicans show an overexpression of Cdr1p and/or ...
Prasad, Rajendra, Rawal, Manpreet K.
openaire +3 more sources
Terpenes as bacterial efflux pump inhibitors: A systematic review
Frontiers in Pharmacology, 2022 Managing antibiotic resistance is a significant challenge in modern pharmacotherapy. While molecular analyses have identified efflux pump expression as an essential mechanism underlying multidrug resistance, the targeted drug development has occurred ...
Kaio Jefté Santos De Oliveira Dias +10 more
doaj +1 more source
Antibiotics, 2023 One promising approach in treating antibiotic-resistant bacteria is to “break” resistances connected with antibacterial efflux by co-administering efflux pump inhibitors (EPIs) with antibiotics. Here, ten compounds, previously optimized to restore the susceptibility to ciprofloxacin (CIP) of norA-overexpressing Staphylococcus aureus, were evaluated for
Rampacci, Elisa +5 more
openaire +4 more sources
Correlation of ciprofloxacin resistance with the AdeABC efflux system in Acinetobacter baumannii clinical isolates [PDF]
, 2014 Background: Acinetobacter baumannii is one of the most important pathogens capable of colonization in burn patients, leading to drug-resistant wound infections.
Ardebili, A., Lari, A.R., Talebi, M.
core +1 more source