Results 31 to 40 of about 64,527 (310)
Microbiology SpectrumCurrently, drug resistance is a formidable obstacle to tuberculosisprevention globally. A deep understanding of the drug-resistance mechanism of Mycobacterium tuberculosis is helpful to deal with this problem.
Ying Long +6 more
doaj +1 more source
The crosstalk between efflux pump and resistance gene mutation in Helicobacter pylori
Gut MicrobesEfflux pumps play a crucial role in the development of antibiotic resistance. The aim of this study was to investigate the relationship between efflux pump gene expression and resistance gene mutations in Helicobacter pylori.
Xiaoling Gong +5 more
doaj +1 more source
Review of: "Inhibiting Efflux Pumps and Resistance Mechanisms: A Mini Review" [PDF]
, 2023 Claus‐Michael Lehr
openalex +3 more sources
Xanthones Active against Multidrug Resistance and Virulence Mechanisms of Bacteria
Antibiotics, 2021 The emergence of multidrug and extensively drug-resistant pathogenic bacteria able to resist to the action of a wide range of antibiotics is becoming a growing problem for public health.
Fernando Durães +6 more
doaj +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Multidrug efflux pumps of Pseudomonas aeruginosa show selectivity for their natural substrates
Frontiers in MicrobiologyAntibiotic-resistant Gram-negative bacteria are an increasing threat to human health. Strategies to restore antibiotic efficacy include targeting multidrug efflux pumps by competitive efflux pump inhibitors. These could be derived from natural substrates
Léna Mazza +12 more
doaj +1 more source
Efflux pump-mediated resistance in chemotherapy
Annals of Medical and Health Sciences Research, 2012 Efflux pump mechanisms perform important physiological functions such as prevention of toxin absorption from the gastrointestinal tract, elimination of bile from the hepatocytes, effective functioning of the blood-brain barrier and placental barrier, and renal excretion of drugs.
Ughachukwu, PO, Unekwe, PC
openaire +4 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source