Results 71 to 80 of about 122,546 (256)
Efflux pumps positively contribute to rifampin resistance in rpoB mutant Mycobacterium tuberculosis
Annals of Clinical Microbiology and AntimicrobialsBackground While several recent studies have documented the importance of efflux pumps as mediators of rifampin (RIF) resistance, it remains uncertain which efflux pumps play major roles in rifampin-resistant Mycobacterium tuberculosis strains harboring ...
Fanrong Meng +16 more
doaj +1 more source
Journal of Infection in Developing Countries, 2016 Introduction: Multidrug resistance in Pseudomonas aeruginosa may be due to efflux pump overexpression. This study phenotypically examined the role of efflux pump inhibitors in decreasing antibiotic cross-resistance between beta-lactams, fluoroquinolones,
Mahshid Talebi-Taher +4 more
doaj +1 more source
The Effect of Thyme (Thymus vulgaris) Extract on the Expression of norA Efflux Pump Gene in Clinical Strains of Staphylococcus aureus [PDF]
Journal of Genetic Resources, 2018 The NorA efflux pump considered as one of the contributors to antibiotic resistance in Staphylococcus aureus strains. One of the challenges of the researchers is finding natural plant compounds with the ability to inhibit the pumps. The aim of this study
Ali Salehzadeh +3 more
doaj +1 more source
Detection of tetracyclines and efflux pump inhibitors [PDF]
Antimicrobial Agents and Chemotherapy, 1993 Screening assays for the detection of tetracyclines and inhibitors of tetracycline efflux pumps are described. The tetracycline assay is based on the observation that the tetA(B) gene encoding the efflux pump of transposon Tn10 is induced by tetracycline.
D M, Rothstein +6 more
openaire +2 more sources
α-Hexylcinnamaldehyde synergistically increases doxorubicin cytotoxicity towards human cancer cell lines [PDF]
, 2016 α-Hexylcinnamaldehyde (HCA), a compound derived from cinnamaldehyde, was evaluated for its potential chemosensitizing ...
DI GIACOMO, Silvia +4 more
core
Comparative transcriptomics of multidrug-resistant Acinetobacter baumannii in response to antibiotic treatments [PDF]
, 2018 Multidrug-resistant Acinetobacter baumannii, a major hospital-acquired pathogen, is a serious health threat and poses a great challenge to healthcare providers.
Chan, Ting-Fung +8 more
core +2 more sources
The apical conjugate efflux pump ABCC2 (MRP2) [PDF]
Pflügers Archiv - European Journal of Physiology, 2006 ABCC2 is a member of the multidrug resistance protein subfamily localized exclusively to the apical membrane domain of polarized cells, such as hepatocytes, renal proximal tubule epithelia, and intestinal epithelia. This localization supports the function of ABCC2 in the terminal excretion and detoxification of endogenous and xenobiotic organic anions,
Anne T, Nies, Dietrich, Keppler
openaire +2 more sources
RND-type Drug Efflux Pumps from Gram-negative bacteria: Molecular Mechanism and Inhibition
Frontiers in Microbiology, 2015 Drug efflux protein complexes confer multidrug resistance on bacteria by transporting a wide spectrum of structurally diverse antibiotics. Moreover, organisms can only acquire resistance in the presence of an active efflux pump.
Henrietta eVenter +3 more
doaj +1 more source
Scientific Reports, 2023 Drug resistance is one of the most difficult challenges facing tuberculosis (TB) control. Drug efflux is among the mechanisms leading to drug resistance.
Nicoletta Campolattano +10 more
doaj +1 more source
Metallochaperones regulate intracellular copper levels. [PDF]
, 2013 Copper (Cu) is an important enzyme co-factor that is also extremely toxic at high intracellular concentrations, making active efflux mechanisms essential for preventing Cu accumulation. Here, we have investigated the mechanistic role of metallochaperones
Adams, Michael +9 more
core +1 more source