Results 101 to 110 of about 997,958 (247)

One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections

Advanced Science, EarlyView.
Catheter‐related bloodstream infections (CRBSI) caused by drug‐resistant Gram‐negative bacteria remain a major clinical challenge. Here, a polydopamine‐assisted depolymerase coating degrades bacterial capsules and restores serum‐mediated killing, effectively suppressing biofilms and reducing bacterial burden in vitro, ex vivo, and in vivo, presenting a
Lingkai Dong, Xingjin Li, Tao Hu, Qianqian Lu, Xiaoxu Zhang, Xi Chen, Yifan Luo, Zhong Zuo, Ronald Man Yeung Wong, Miao Xu, Tiancong Zhao, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Tigecycline susceptibility and the role of efflux pumps in tigecycline resistance in KPC-producing Klebsiella pneumoniae.

PLoS ONE, 2015
KPC-producing Klebsiella pneumoniae isolates have emerged as important pathogens of nosocomial infections, and tigecycline is one of the antibiotics recommended for severe infections caused by KPC-producing K. pneumoniae.
Fang He, Ying Fu, Qiong Chen, Zhi Ruan, Xiaoting Hua, Hua Zhou, Yunsong Yu   +6 more
doaj   +1 more source

Evaluation of efflux pump activity of multidrug-resistant Salmonella Typhimurium isolated from poultry wet markets in India

, 2019
Prasanna Vadhana Anbazhagan,1 Prasada Rao Thavitiki,2 Manasa Varra,2 Latchumikanthan Annamalai,3 Ramya Putturu,4 Venkateswara Rao Lakkineni,4 Pavan Kumar Pesingi41Department of Veterinary Microbiology, College of Veterinary Science, Sri Venkateswara ...
Putturu R, Anbazhagan PV, Lakkineni VR, Varra M, Annamalai L, Thavitiki PR, Pesingi PK   +6 more
core  

Heteroatom‐Mediated Covalent Organic Framework Membranes With Nitrogen‐Enriched Nanochannels for Efficient Desalination

Advanced Science, EarlyView.
Heteroatom precursor engineering serves as a molecular‐level strategy to tailor hydrazide monomer reactivity and diffusion kinetics, enabling controlled assembly of highly crystalline COF membranes with ultramicroporous channels. The nitrogen‐enriched nanochannels deliver high water/ion selectivity via simultaneous water transport acceleration and ion ...
Guishan Hu, Muning Chen, Yunqiu Zhou, Yu Zhen, Miaomiao Tian, Yatao Zhang, Jingwei Hou, Junyong Zhu, Yong Wang   +8 more
wiley   +1 more source

Phenotypic and Genotypic Efflux Pumps in Resistance to Fluoroquinolones in E.coli Isolated from Inpatients in Kermanshah Hospitals in 2013 [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2017
Background: Antibiotic resistance rates in E. coli are rapidly rising, especially with regard to fluoroquinolones. One of the mechanisms that lead to antibiotic resistance is efflux pumps.
Maryam Doosti Mohajer, Hamid Pajavand, Ramin Abiri   +2 more
doaj  

Scalable and Chromatography-Free Synthesis of Efflux Pump Inhibitor Phenylalanine Arginine β-Naphthylamide for Its Validation in Wild-Type Bacterial Strains. [PDF]

ChemMedChem, 2023
Russo CM, Howey KG, O'Reilly MC.
europepmc   +1 more source

Capsaicin, a novel inhibitor of the NorA efflux pump, reduces the intracellular invasion of Staphylococcus aureus

, 2020
Objectives: To delineate the role of capsaicin (8-methyl-N-vanillyl-6-nonenamide) as an inhibitor of the NorA efflux pump and its impact on invasion of macrophages by Staphylococcus aureus. Methods: Capsaicin in combination with ciprofloxacin was tested
Jai Parkash Sharma, Inshad Ali Khan, Nitin Pal Kalia, Priya Mahajan, Rukmankesh Mehra, Amit Nargotra, Surrinder Koul   +6 more
core  

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Efflux pump inhibitor combined with ofloxacin decreases MRSA biofilm formation by regulating the gene expression of NorA and quorum sensing. [PDF]

RSC Adv, 2023
Lu X, Wang G, Xie Y, Tang W, Liu B, Zhang J.   +5 more
europepmc   +1 more source