Results 31 to 40 of about 997,958 (247)

Premature Termination of MexR Leads to Overexpression of MexAB-OprM Efflux Pump in Pseudomonas aeruginosa in a Tertiary Referral Hospital in India. [PDF]

PLoS ONE, 2016
OBJECTIVES:The present study was undertaken to investigate the mutations that are present in mexR gene of multidrug resistant (MDR) isolates of Pseudomonas aeruginosa collected from a tertiary referral hospital of north east India.
Debarati Choudhury, Anamika Ghose, Debadatta Dhar Chanda, Anupam Das Talukdar, Manabendra Dutta Choudhury, Deepjyoti Paul, Anand Prakash Maurya, Atanu Chakravarty, Amitabha Bhattacharjee   +8 more
doaj   +1 more source

New AcrAB-TolC efflux pump inhibitor synthesis

, 2022
Jaunu AcrAB-TolC efluksa sūkņa inhibitoru sintēze. Pauniņa L., zinātniskais vadītājs Dr. sci. nat. Veliks J., konsultante Dr. chem. Madre M. Bakalaura darbs, 55 lappuses, 29 attēli, 1 tabula, 42 literatūras avoti, 4 pielikumi. Latviešu valodā.
Pauniņa, Laura
core  

Phytochemical Composition and Anti-Efflux Pump Activity of Hydroalcoholic, Aqueous, and Hexane Extracts of Artemisia tournefortiana in Ciprofloxacin-Resistant Strains of Salmonella enterica Serotype Enteritidis

Iranian Journal of Public Health, 2020
Background: The AcrB efflux pump in Salmonella species plays a significant role in the development of antibiotic resistance in ciprofloxacin-resistant Salmonella enteritidis.
Marjan KHOSRAVANI, Mohammad Mehdi SOLTAN DALLAL, Mehdi NOROUZI   +2 more
doaj   +1 more source

Inhibitors of the Candida albicans Major Facilitator Superfamily Transporter Mdr1p Responsible for Fluconazole Resistance. [PDF]

PLoS ONE, 2015
To identify a novel class of inhibitors of fungal transporters involved in drug resistance.A series of structurally-related low molecular mass compounds was synthesized using combinatorial chemistry of a cyclobutene-dione (squarile) core. These compounds
Mikhail V Keniya, Edmond Fleischer, Anette Klinger, Richard D Cannon, Brian C Monk   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Pseudomonas aeruginosa mexR and mexEF Antibiotic Efflux Pump Variants Exhibit Increased Virulence

Antibiotics, 2021
Antibiotic-resistant Pseudomonas aeruginosa infections are the primary cause of mortality in people with cystic fibrosis (CF). Yet, it has only recently become appreciated that resistance mutations can also increase P.
Mylene Vaillancourt, Sam P. Limsuwannarot, Catherine Bresee, Rahgavi Poopalarajah, Peter Jorth   +4 more
doaj   +1 more source

Elucidation of the structure and molecular mechanism of the tripartite multidrug efflux pumps in the Gram-negative pathogens: Vibrio cholerae and Neisseria gonorrhoeae [PDF]

, 2006
In bacteria, multidrug efflux systems have been identified as significant determinants of resistance recently. These resistance pumps are widely distributed in bacterial species and many pathogenic bacteria posses them, which play an important role in ...
Du, Dijun
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The effect of carbonyl cyanide m-chlorophenyl-hydrazine on antibiotic susceptibility in MDR Enterobacteriaceae isolates in Babylon, Iraq

Medical Journal of Babylon
Background: One of the efflux pump inhibitors is carbonyl cyanide 3-chlorophenylhydrazone (CCCP) that has often been found to increase the susceptibility of a number of multi-drug resistant (MDR) MDR bacteria, isolated from human clinical specimens ...
Hadeel Qasim Jebur, Alaa H. Al-Charrakh
doaj   +1 more source

First emergence of acrAB and oqxAB mediated tigecycline resistance in clinical isolates of Klebsiella pneumoniae pre-dating the use of tigecycline in a Chinese hospital. [PDF]

PLoS ONE, 2014
Tigecycline is one of the few therapeutic options for treating infections caused by some multi-drug resistant pathogens, such as Klebsiella pneumoniae. However, tigecycline-resistant K. pneumoniae has been discovered recently in China. From 2009 to 2013,
Xue Zhong, Hongtao Xu, Dongke Chen, Haijian Zhou, Xin Hu, Gang Cheng   +5 more
doaj   +1 more source